第779回 生医研セミナー(多階層生体防御システム研究拠点)
下記の通り、Chukwuemeka George Anene-Nzelu 先生によるセミナーを開催致します。皆様のご来聴を心より歓迎いたします。
※セミナーは英語で行われます。(Seminar in English)
演題 / Title
The Role of OGG1 in doxorubicin-induced cardiotoxicity
演者 / Speaker
Dr. Chukwuemeka George Anene-Nzelu
Cardiovascular Research Institute,
Yong Loo Lin School of Medicine,
National University of Singapore
日時 / Date
2018年11月1日(木) Nov. 1(Thu), 2018
15：00～16：30
場所 / Venue
病院キャンパス 生体防御医学研究所 本館1階 会議室
以下の地図の31番です。
（http://www.kyushu-u.ac.jp/f/33951/2018hospital_2.pdf）
Seminar Room, 1F, Main Building, Medical Institute of Bioregulation, Hospital Campus
No.31 on the following linked map.
（http://www.kyushu-u.ac.jp/f/33952/2018hospital_2-en.pdf）
要 旨 / Abstract
Doxorubicin is an anti-cancer drug widely used to treat a variety of malignancies. Its major adverse effect is a dose-dependent toxicity to the heart. The proposed mechanisms through which it produces cardiotoxicity includes oxidative stress, which leads to cardiac mitochondrial dysfunction, DNA damage and induction of apoptosis. 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most common DNA lesions induced by reactive oxygen species (ROS) and is considered an index of DNA damage. High levels of 8-oxoG have been correlated with increased mutation, loss of mitochondrial DNA, as well as apoptosis. 8-OxoG DNA glycosylase 1 encoded by OGG1 is the most important enzyme that recognizes and excises 8-oxoG and maintain low level of 8-oxoG in DNA thus preventing further cellular damage. We set out to study the effect of lack of OGG1 on cardiac functions following doxorubicin administration using Ogg1-knockout (KO) mice. Our results show that Ogg1-KO mice developed a more severe cardiac dilatation, greater reduction of ejection fraction and were more likely to die during the course of the treatment. RNA sequencing analysis showed upregulation of many genes involved in apoptosis in the Ogg1-KO hearts and this was confirmed in histological examination. These results thus demonstrate that OGG1 attenuates doxorubicin-induced cardiotoxicity by repairing 8-oxoG.
演者紹介 / Speaker Introduction
Dr. Chukwuemeka George Anene-Nzelu is a Postdoctoral research fellow at the Cardiovascular Research Institute Singapore. He obtained his PhD in Tissue Engineering at the National University Singapore. He currently works on the role of DNA damage in heart failure as well as understanding 3D genome organization in the heart. This work was partly performed in the Cooperative Research Project Program of the Medical Institute of Bioregulation, Kyushu University.
連絡先 / Contact
生体防御医学研究所 脳機能制御学分野
中別府 雄作
092(642)6800
Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation
Yusaku Nakabeppu
TEL: 092(642)6800