MIB Seminar
Common Research Facilities
  • Laboratory of Embryonic and Genetic Engineering
  • Laboratory for Research Support
Contact

Medical Institute of Bioregulation Kyushu University
3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JAPAN
TEL+81-92-642-6814
FAX+81-92-642-6246

The 778th MIB Seminar (Joint Usage/Research Center for the Multi-stratified Host Defense System)
 joint with the seminar of Grant-in-Aid for Scientific Research on Innovative Areas「Ensuring integrity in gametogenesis」


[Seminar in English]

Title

Epigenetics in the male germline from stem cells to sperm

Speaker

Dr. Satoshi Namekawa
Associate Professor
Division of Reproductive Sciences
Cincinnati Children's Hospital Medical Center

Date

Nov. 15 (Thu), 2018
17:00~18:00

Venue

Seminar Room, 1F, Main Building, Medical Institute of Bioregulation, Hospital Campus
No.31 on the following linked map.
(http://www.kyushu-u.ac.jp/f/33952/2018hospital_2-en.pdf)

Abstract

The epigenetic mechanisms of germ cells are ultimately responsible for the perpetuity of life. Male germ cells undergo the major transition: the mitosis-to-meiosis transition in spermatogenesis. Recently, we identified two major epigenetic mechanisms that govern this transition. While superenhancers drive robust expression of spermatogenesis genes, endogenous retroviruses function as enhancers and drive species-specific transcriptomes. Furthermore, by performing Hi-C (genome-wide chromosome conformation capture), we reveal the 3D chromatin organization of male germ cells from the meiotic stage to sperm. These chromatin characteristics undergo progressive strengthening and consolidation to form an abundance of constrained topological associated domains (TADs) in mature sperm.

References

Maezawa S, Hasegawa K, Yukawa M, Kubo N, Sakashita A, Alavattam KG, Sin HS, Kartashov AV, Sasaki H, Barski A, Namekawa SH.
Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline.
Proc Natl Acad Sci U S A. 2018 May 8; 115(19):4957-4962.

Contact

Division of Epigenomics and Development, MIB
Hiroyuki SASAKI
Phone:092(642)6759

↑ Page Top