第778回 生医研セミナー(多階層生体防御システム研究拠点)

      新学術領域「配偶子インテグリティの構築」合同セミナー

下記の通り、行川 賢 先生によるセミナーを開催致します。皆様のご来聴を心より歓迎いたします。

※セミナーは英語で行われます。(Seminar in English)


演題 / Title

Epigenetics in the male germline from stem cells to sperm

演者 / Speaker

行川 賢 先生
シンシナティ小児病院・准教授

Dr. Satoshi Namekawa
Associate Professor
Division of Reproductive Sciences
Cincinnati Children's Hospital Medical Center

日時 / Date

2018年11月15日(木) Nov. 15(Thu), 2018
17:00~18:00

場所 / Venue

病院キャンパス 生体防御医学研究所 本館1階 会議室
以下の地図の31番です。
(http://www.kyushu-u.ac.jp/f/33951/2018hospital_2.pdf)

Seminar Room, 1F, Main Building, Medical Institute of Bioregulation, Hospital Campus
No.31 on the following linked map.
(http://www.kyushu-u.ac.jp/f/33952/2018hospital_2-en.pdf)

要 旨 / Abstract

The epigenetic mechanisms of germ cells are ultimately responsible for the perpetuity of life. Male germ cells undergo the major transition: the mitosis-to-meiosis transition in spermatogenesis. Recently, we identified two major epigenetic mechanisms that govern this transition. While superenhancers drive robust expression of spermatogenesis genes, endogenous retroviruses function as enhancers and drive species-specific transcriptomes. Furthermore, by performing Hi-C (genome-wide chromosome conformation capture), we reveal the 3D chromatin organization of male germ cells from the meiotic stage to sperm. These chromatin characteristics undergo progressive strengthening and consolidation to form an abundance of constrained topological associated domains (TADs) in mature sperm.

参考文献 / References

Maezawa S, Hasegawa K, Yukawa M, Kubo N, Sakashita A, Alavattam KG, Sin HS, Kartashov AV, Sasaki H, Barski A, Namekawa SH.
Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline.
Proc Natl Acad Sci U S A. 2018 May 8; 115(19):4957-4962.

連絡先 / Contact

生体防御医学研究所 エピゲノム制御学分野
佐々木 裕之
092(642)6759

Division of Epigenomics and Development, MIB
Hiroyuki SASAKI
092(642)6759