業績リスト
教授:佐々木 裕之
原著論文  Original Research Papers  / 英文 English  (1990年以前25編は省略)
Ishiuchi, T., Ohishi, H., Sato, T., Kamimura, S., Yorino, M., Abe, S., Suzuki, A., Wakayama, T., Suyama, M. & Sasaki, H.
Zfp281 shapes the transcriptome of trophoblast stem cells and is essential for placental development.
Cell Rep. 27, 1742-1754 (2019)
PubMed

Au Yueng, W.K., Brind’Amour, J., Hatano, Y., Yamagata, K., Feil, R., Lorincz, M.C., Tachibana, M., Shinkai, Y. & Sasaki, H.
Histone H3K9 methyltransferase G9a in oocytes is essential for preimplantation development but dispensable for CG methylation protection.
Cell Rep. 27, 282-293 (2019)
PubMed

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y.
Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer.
Anticancer Res. 39, 671-677 (2019)
PubMed

Unoki, M., Funabiki, H., Velasco, G., Francastel, C. & Sasaki, H.
CDCA7 and HELLS mutations undermine non-homologous end joining in centromeric instability syndrome.
J. Clin. Invest. 129, 78-92 (2019)
PubMed

Kamae, C., Imai, K., Kato, T., Okano, T., Honma, K., Nakagawa, N., Yeh, T. W., Noguchi, E., Ohara, A., Shigemura, T., Takahashi, H., Takakura, S., Hayashi, M., Honma, A., Watanabe, S., Shigemori, T., Ohara, O., Sasaki, H., Kubota, T., Morio, T., Kanegae, H. & Nonoyama, S.
Clinical and immunological characterization of ICF syndrome in Japan.
J. Clin. Immunol. 38, 927-937 (2018)
PubMed

Yamashiro, C., Sasaki, K., Yabuta, Y., Kojima, Y., Nakamura, T., Okamoto, I., Yokobayashi, S., Murase, Y., Ishikura, I., Shirane, K., Sasaki, H., Yamamoto, T. & Saitou, M.
Generation of human oogonia from induced pluripotent stem cells in vitro.
Science 362, 356-360 (2018)
PubMed

Sakakibara, Y., Nagao, K., Blewitt, M., Sasaki, H., Obuse, C. & Sado, T.
Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice.
Development 145, dev166462 (2018)
PubMed

Maezawa, S., Hasegawa, K., Yukawa, M., Kubo, N., Sakashita, A., Alabattam, K.G., Sin, H.S., Kartashov, A.V., Sasaki, H., Barski, A. & Namekawa, S.H.
Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline.
Proc. Natl. Acad. Sci. USA 115, 4957-4962 (2018)
PubMed

Matsuda, S., Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotoh, K., Fukuda, K., Sasaki, H., Suzuki, T. & Kang, D.
Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA.
Sci. Rep. 8, 5801 (2018)
PubMed

Okae, H., Toh, H., Sato, T., Hiura, H., Takahashi, S., Shirane, K., Kabayama, Y., Suyama, M., Sasaki, H. & Arima, T.
Derivation of human trophoblast stem cells.
Cell Stem Cell 22, 50-63 (2018)
PubMed

Suzuki, A., Kawano, S., Mituyama, T., Suyama, M., Kanai, Y., Shirahige, K., Sasaki, H., Tokunaga, K., Tsuchihara, K., Sugano, S., Nakai, K. & Suzuki, Y.
DBTSS/DBKERO for integrated analysis of transcriptional regulation.
Nucl. Acids Res. 46, D229-D238 (2018)
PubMed

Shimosuga, K., Fukuda, K., Sasaki, H. & Ichiyanagi, K.
Locus-specific hypomethylation of the mouse IAP retrotransposon is associated with transcription factor-binding sites.
Mobile DNA 8, 20 (2017)
PubMed

Maenohara, S., Unoki, M., Toh, H., Ohishi, H., Sharif, J., Koseki, H. & Sasaki, H.
Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos.
PLoS Genet. 13, e1007042. (2017)
PubMed

Chigi, Y., Sasaki, H. & Sado, T.
The 5' region of Xist RNA has the potential to associate with chromatin through the A-repeat.
RNA 23, 1894-1901 (2017)
PubMed

Inoue, K., Ichiyanagi, K., Fukuda, K., Glinka, M. & Sasaki, H.
Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice.
PLoS Genet. 13, e1006926 (2017)
PubMed

Sakata, Y., Nagao, K., Hoki, Y., Sasaki, H., Obuse, C. & Sado, T.
Defects in dosage compensation impact global gene regulation in the mouse trophoblast.
Development 144, 2784-2797 (2017)
PubMed

Fukuda, K., Inoguchi, Y., Ichiyanagi, K., Ichiyanagi, T., Go, Y., Nagano, M., Yanagawa, Y., Takaesu, N., Ohkawa, Y., Imai, H. & Sasaki, H.
Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability.
Hum. Mol. Genet. 26, 3508-3519 (2017)
PubMed

Ohta, H., Kurimoto, K., Okamoto, I., Nakamura, T., Yabuta, Y., Miyauchi, H., Yamamoto, T., Okuno, Y., Hagiwara, M., Shirane, K., Sasaki, H. & Saitou, M.
In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.
EMBO J. 36, 1888-1907 (2017)
PubMed

Hidaka, N., Iwama, E., Kubo, N., Harada, T., Miyawaki, K., Tanaka, K., Okamoto, I., Baba, E., Akashi, K., Sasaki, H. & Nakanishi, Y.
Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non-small cell lung cancer.
Lung Cancer 108, 75-82 (2017)
PubMed

Kabayama, Y., Toh, H., Katanaya, A., Sakurai, T., Chuma, S., Kuramochi-Miyagawa, S., Saga, Y., Nakano, T. & Sasaki, H.
Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes.
Nucl. Acids Res. 45, 5387-5398 (2017)
PubMed

Kobayashi, M., Kato, H., Hada, H., Itoh-Nakadai, A., Fujiwara, T., Muto, A., Inoguchi, Y., Ichiyanagi, K., Houjou, W., Tomosugi, N., Sasaki, H., Harigae, H. & Igarashi, K.
Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency.
Haematologica 102, 454-465 (2017)
PubMed

Toh, H., Shirane, K., Miura, F., Kubo, N., Ichiyanagi, K., Hayashi, K., Saitou, M., Suyama, M., Ito, T. & Sasaki, H.
Software updates in the Illumina HiSeq platform affect whole-genome bisulfite sequencing.
BMC Genomics 18, 31 (2017)
PubMed

Ishikura, Y., Yabuta, Y., Ohta, H., Hayashi, K., Nakamura, T., Okamoto, I., Yamamoto, T., Kurimoto, K., Shirane, K., Sasaki, H. & Saitou, M.
In vitro derivation and propagation of spermatogonial stem cell activity from mouse pluripotent stem cells.
Cell Rep. 17, 2789-2804 (2016)
PubMed

Hamada, H., Okae, H., Toh, H., Chiba, H., Hiura, H., Shirane, K., Sato, T., Suyama, M., Yaegashi, N., Sasaki, H. & Arima, T.
Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placenta.
Am. J. Hum. Genet. 99, 1045-1058 (2016)
PubMed

Shirane, K., Kurimoto, K., Yabuta, Y., Yamaji, M., Satoh, J., Ito, S., Watanabe, A., Hayashi, K., Saitou, M. & Sasaki, H.
Global landscape and regulatory principles of DNA methylation reprogramming for germ cell specification by mouse pluripotent stem cells.
Dev. Cell 39, 87-103 (2016)
PubMed

Amouroux, R., Nashun, B., Shirane, K., Nakagawa, S., Hill, P.W., D'Souza, Z., Nakayama, M., Matsuda, M., Turp, A., Ndjetehe, E., Encheva, V., Kudo, N.R., Koseki, H., Sasaki, H. & Hajkova, P.
De novo DNA methylation drives 5hmC accumulation in mouse zygotes.
Nat. Cell Biol. 18, 225-233 (2016)
PubMed

Amakawa, Y., Sakata, Y., Hoki, Y., Arata, S., Shioda, S., Fukagawa, T., Sasaki, H. & Sado, T.
A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.
Development 142, 4299-4308 (2015)
PubMed

Kubo, N., Toh, H., Shirane, K., Shirakawa, T., Kobayashi, H., Sato, T., Sone, H., Sato, Y., Tomizawa, S., Tsurusaki, Y., Shibata, H., Saitsu, H., Suzuki, Y., Matumoto, N., Suyama, M., Kono, T., Ohbo, K. & Sasaki, H.
DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.
BMC Genomics 16, 624 (2015)
PubMed

Thijssen, P.E., Ito, Y., Grillo, G., Wang, J., Velasco, G., Nitta, H., Unoki, M., Yoshihara, M., Suyama, M., Sun, Y., Lemmers, R.J.L.F., de Greef, J.C., Gennery, A., Picco, P., Kloeckener-Gruissem, B., Gungor, T., Reisli, I., Picard, C., Kebaili, K., Roquelaure, B., Iwai, T., Kondo, I., Kubota, T., van Ostaijen-Ten Dam, M.M., van Tol, M.J.D., Weemaes, C., Francastel, C., van der Maarel, S.M. & Sasaki. H.
Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.
Nat. Commun. 6, 7870 (2015)
PubMed

Ichiyanagi, T., Ichiyanagi, K., Ogawa, A., Kuramochi-Miyagawa, S., Nakano, T., Chuma, S., Sasaki, H. & Udono, H.
HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse.
Nucl. Acids Res. 42, 11903-11911 (2014)
PubMed

Liu, S., Brind’Amour, J., Karimi, M.M., Shirane, K., Bogutz, A., Lefebvre, L., Sasaki, H., Shinkai, Y. & Lorincz, M.C.
Setdb1 is required for germ line development and silencing of H3K9me3 marked endogenous retroviruses in primordial germ cells.
Genes Dev. 28, 2041-2055 (2014)
PubMed

Velasco, G., Walton, L. E., Sterlin, D., Hedouin, S., Nitta, H., Ito, Y., Fouyssac F., Megarbane, A., Sasaki, H., Picard, C. & Francastel, C.
Germline genes hypomethylation and expression define a molecular signature in peripheral blood of ICF patients: implications for diagnosis and etiology.
Orphanet J. Rare Dis. 9, 56 (2014)
PubMed

Shiura, H., Okamoto, A., Sasaki, H. & Abe, K.
Whole-mount MeFISH: a novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression.
PLoS One 9, e95750 (2014)
PubMed

Liao, H.-F., Chen, W.S.C., Chen, Y.-H., Kao, T.-H., Tseng, Y.-T., Lee, C.-Y., Chiu, Y.-C., Lee, P.-L., Lin, Q.-J., Ching, Y.-H., Hata, K., Cheng, W.T.K., Tsai, M.-H., Sasaki, H., Ho, H.-N., Wu, S.-C. , Huang, Y.-H., Yen, P. & Lin, S.-P.
DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells.
Development 141, 2402-2413 (2014)
PubMed

Yokomizo, H., Inoguchi, T., Sonoda, N., Sakaki, Y., Maeda, Y., Inoue, T., Hirata, E., Takei, R., Ikeda, N., Fujii, M., Fukuda, K., Sasaki, H. & Takayanagi, R.
Maternal high fat diet induces insulin resistance and deterioration of pancreatic β cell function in adult offspring with gender differences in mice.
Am. J. Physiol. Endocrinol. Metab. 306, E1163-1175 (2014)
PubMed

Okae, H., Matoba, S. Nagashima, T., Mizutani, E., Inoue, K., Ogonuki, N., Chiba, H., Funayama, R., Tanaka, S., Yaegashi, N., Nakayama, K., Sasaki, H., Ogura, A. & Arima, T.
RNA sequencing-based identification of aberrant imprinting in cloned mice.
Hum. Mol. Genet. 23, 992-1001 (2014)
PubMed

Li, Y., Miyanari, Y., Shirane, K., Nitta, H., Kubota, T., Ohashi, H., Okamoto, A. & Sasaki, H.
Sequence-specific microscopic visualization of DNA methylation status at satellite repeats in individual cell nuclei and chromosomes.
Nucl. Acids Res. 41, e186 (2013)
PubMed

Nitta, H., Unoki, M., Ichiyanagi, K., Kosho, T., Shigemura, T., Takahashi, H., Velasco, G., Francastel, C., Picard, C., Kubota, T. & Sasaki, H.
Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients.
J. Hum. Genet. 58, 455-460 (2013)
PubMed

Fukuda, K., Ichiyanagi, K., Yamada, Y., Go, Y., Udono, T., Wada, S., Maeda, T., Soejima, H., Saitou, N., Ito, T. & Sasaki, H.
Regional DNA methylation differences between humans and chimpanzees are associated with genetic changes, transcriptional divergence and disease genes.
J. Hum. Genet. 58, 446-454 (2013)
PubMed

Shirane, K., Toh, H., Kobayashi, H., Miura, F., Chiba, H., Ito, T., Kono, T. & Sasaki, H.
Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases.
PLoS Genet. 9, e1003439 (2013)
PubMed

Unoki, M., Masuda, A., Dohmae, N., Arita, K., Yoshimatsu, M., Iwai, Y., Fukui, Y., Ueda, K., Hamamoto, R., Shirakawa, M., Sasaki, H. & Nakamura, Y.
Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6).
J. Biol. Chem. 288, 6053-6062 (2013)
PubMed

Yamamoto, Y., Watanabe, T., Hoki, Y., Shirane, K., Li, Y., Ichiyanagi, K., Kuramochi-Miyagawa, S., Toyoda, A., Fujiyama, A., Oginuma, M., Suzuki, H., Sado, T., Nakano, T. & Sasaki, H.
Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus.
Genome Res. 23, 292-299 (2013)
PubMed

Ichiyanagi, T., Ichiyanagi, K., Miyake, M. & Sasaki, H.
Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development.
Nucl. Acids Res. 41, 738-745 (2013)
PubMed

Liu, Y., Toh, H., Sasaki, H., Zhang, X. & Cheng, X.
An atomic model of ZFP57 recognition of CpG methylation within a specific DNA sequence.
Genes Dev. 26, 2374-2379 (2012)
PubMed

Takahashi, T., Matsuzaki, H., Tomizawa, S., Okamura, E., Ichiyanagi, T., Fukamizu, A., Sasaki, H. & Tanimoto, K.
Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice.
Gene 508, 26-34 (2012)
PubMed

Okae, H., Hiura, H., Miyauchi, N., Abe, C., Nishida, Y., Funayama, R., Tanaka, S., Chiba, H., Yaegashi, N., Nakayama, K., Sasaki, H. & Arima, T.
Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression.
Hum. Mol. Genet. 21, 548-558 (2012)
PubMed

Ohnishi, Y., Totoki, Y., Toyoda, A., Watanabe, T., Yamamoto, Y., Tokunaga, K., Sakaki, Y., Sasaki, H. & Hohjoh, H.
Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development.
Mol. Biol. Rep. 39, 903-909 (2012)
PubMed

Ichiyanagi, K., Li, Y., Watanabe, T., Ichiyanagi, T., Fukuda, K., Kitayama, J., Yamamoto, Y., Kuramochi-Miyagawa, S., Nakano, T., Yabuta, Y., Seki, Y., Saitou, M. & Sasaki, H.
Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development.
Genome Res. 21, 2058-2066 (2011)
PubMed

Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D. & Sasaki, H.
Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.
Science 332, 848-852 (2011)
PubMed

Hoki, Y., Ikeda, R., Mise, N., Sakata, Y., Ohhata, T., Sasaki, H., Abe, K. & Sado, T.
Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse
Development 138, 2649-2659 (2011)
PubMed

Watanabe, T., Chuma, S. Yamamoto, Y., Kuramochi-Miyagawa, S., Totoki, Y., Toyoda, A., Hoki, Y., Fujiyama, A., Shibata, T., Sado, T., Noce, T., Nakano, T., Nakatsuji, N., Lin, H. & Sasaki, H.
MitoPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.
Dev. Cell 20, 364-375 (2011)
PubMed

Tomizawa, S., Kobayashi, H., Watanabe, T., Andrews, S., Hata, K., Kelsey, G. & Sasaki, H.
Dynamic stage-specific changes of imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes.
Development 128, 811-820 (2011)
PubMed

Borgel, J., Guibert, S., Li, Y., Chiba, H., Schuebeler, D., Sasaki, H., Forne, T. & Weber, M.
Targets and dynamics of promoter DNA methylation during early mouse development.
Nat. Genet. 42, 1093-1100 (2010)
PubMed

Hiura, H., Sugawara, A., Ogawa, H., John, R., Miyauchi, N., Miyanari, Y., Horiike, T., Li, Y., Yaegashi, N., Sasaki, H., Kono, T. & Arima, T.
A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip.
Nucl. Acids Res. 38, 4929-4945 (2010)
PubMed

Kuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Takamatsu, K., Chuma, S., Kojima-Kita, K., Shiromoto, Y., Asada, N., Kimura, T., Nakatsuji, N., Noce, T., Sasaki, H. & Nakano, T.
MVH in piRNA processing and gene silencing of retrotransposons.
Genes Dev. 24, 887-892 (2010)
PubMed

Kaneda, M., Hirawasa, R., Chiba, H., Okano, M., Li, E. & Sasaki, H.
Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation.
Genes Cells 15, 169-179 (2010)
PubMed

Shoji, M., Tanaka, T., Hosokawa, M., Reuter, M., Stark, A., Kato, Y., Kondoh, G., Okawa, K., Chujo, T., Suzuki, T., Hata, K., Martin, S.L., Noce, T., Kuramochi-Miyagawa, S., Nakano, T., Sasaki, H., Pillai, R.S., Nakatsuji, N. & Chuma, S.
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
Dev. Cell 17, 745-746 (2009)
PubMed

Yamaguchi, S., Kurimoto, K., Yabuta, Y., Sasaki, H., Nakatsuji, N., Saitou, M. & Tada, T.
Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells.
Development 136, 4011-4020 (2009)
PubMed

Takashima, S., Takehashi, M., Lee, J., Chuma, S. Okano, M., Hata, K. Suetake, I., Nakatsuji, N., Miyoshi, H., Tajima, S., Tanaka, Y., Toyokuni, S., Sasaki, H., Kanatsu-Shinohara, M. & Shinohara, T.
Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenesis defects.
Biol. Reprod. 81, 155-164 (2009)
PubMed

Hoki, Y., Kimura, N., Kanbayashi, M., Ohhata, T., Amakawa, Y., Sasaki, H. & Sado, T.
A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.
Development 136, 139-146 (2009)
PubMed

Hirasawa, R. & Sasaki, H.
Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos.
Gene Expr. Patt. 9, 27-30 (2009)
PubMed

Chiba, H., Hirasawa, R., Kaneda, M., Amakawa, Y., Li, E., Sado, T. & Sasaki, H.
De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes.
Genesis 46, 768-774 (2008)
PubMed

Hu, Y.-G., Hirasawa, R., Hu, J.-L., Hata, K., Jin, Y., Chen, T., Li, E., Rigolet, M., Viegas-Pequignot, E., Sasaki, H. & Xu, G.-L.
Regulation of DNA methylation activity through DNMT3L promoter methylation by DNMT3 enzymes in embryonic development.
Hum. Mol. Genet. 17, 2654-2664 (2008)
PubMed

Hirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R. & Sasaki, H.
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development.
Genes Dev. 22, 1607-1616 (2008)
PubMed

Watanabe, T., Totoki, Y., Toyoda, A., Kaneda, M., Kuramochi-Miyagawa, S., Obata, Y., Chiba, H., Kohara, Y., Kono, T., Nakano, T., Surani, M.A., Sakaki, Y. & Sasaki, H.
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes.
Nature 453, 539-543 (2008)
PubMed

Kuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Totoki, Y., Toyoda, A., Ikawa, M., Asada, N., Kojima, K., Yamaguchi, Y., Ijiri, T., Hata, K., Li, E., Matsuda, Y., Kimura, T., Okabe, M., Sakaki, Y., Sasaki, H. & Nakano, T.
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.
Genes Dev. 22, 908-917 (2008)
PubMed

Li, J.-Y., Pu, M.-T., Hirasawa, R., Li, B.-Z., Huang, Y.-N., Zeng, R., Jing, N.-H., Chen, T., Li, E., Sasaki, H. & Xu, G.-L.
Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog.
Mol. Cell. Biol. 27, 8748-8759 (2007)
PubMed

Yakushiji, N., Suzuki, M., Satoh, A., Shiroishi, T., Kobayashi, H., Sasaki, H., Ide, H. & Tamura, K.
Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regenetration in amphibians.
Dev. Biol. 312, 171-182 (2007)
PubMed

Watanabe, T., Totoki, Y., Sasaki, H., Imai, H. & Minami, N.
Analysis of small RNA profiles during development.
Methods Enzymol. 427, 155-169 (2007)
PubMed

Parker-Katiraee, L., Carson, A. R., Yamada, T., Arnaud, P., Feil, R., Abu-Amero, S. N., Moore, G. E., Kaneda, M., Perry, G. H., Stone, A. C., Lee, C., Meguro-Horike, M., Sasaki, H., Kobayashi, K., Nakabayashi, K. & Scherer, S. W.
Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.
PLoS Genet. 3 (5), 655-678 (2007)
PubMed

Kato, Y., Keneda, M., Hata, K., Kumaki, K., Hisano, M., Kohara, Y., Okano, M., Li, E., Nozaki, M. & Sasaki, H.
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse.
Hum. Mol. Genet. 16(19): 2272-2280 (2007)
PubMed

Kobayashi, H., Sato, A., Otsu, E., Hiura, H., Tomatsu, C., Utsunomiya, T., Sasaki, H., Yaegashi, N. & Arima, T.
Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients.
Hum. Mol. Genet. 16(21): 2542-2551 (2007)
PubMed

Sado, T., Hoki, Y. & Sasaki, H.
Tsix defective in splicing is competent to establish Xist silencing.
Development 133(24): 4925-4931 (2006)
PubMed

Watanabe, T., Takeda, A., Tsukiyama, T., Mise, K., Okuno, T., Sasaki, H., Minami, N. & Imai, H.
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testis.
Genes Dev. 20, 1732-1743 (2006)
PubMed

Arima, T., Hata, K., Tanaka, S., Kusumi, M., Li, E., Kato, K., Sasaki, H. & Wake, N.
Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue.
Dev. Biol. 297, 361-373 (2006)
PubMed

Fukasawa, M., Kimura, M., Morita, S., Matsubara, K., Yamanaka, S., Endo, C., Sakurada, A., Sato, M., Kondo, T., Horii, A., Sasaki, H. & Hatada, I.
Microarray analysis of promoter methylation in lung cancers.
J. Hum. Genet. 51, 368-374, (2006)
PubMed

Xie, Z.-H., Huang, Y.-N., Chen, Z.-X., Riggs, A.D., Ding, J.-P., Gowher, H., Jeltsch, A., Sasaki, H., Hata, K. & Xu, G.-L.
Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L.
Hum. Mol. Genet. 15, 1375-1385, (2006)
PubMed

Arnaud, P., Hata, K., Kaneda, M., Li, E. Sasaki, H., Feil, R. & Kelsey, G.
Stochastic imprinting in the progeny of Dnmt3L-/- females.
Hum. Mol. Genet. 15, 589-598 (2006)
PubMed

Hatada, I., Fukasawa, M., Kimura, M., Morita, S., Yamada, K., Yoshikawa, T., Yamanaka, S., Endo, C., Sakurada, A., Sato, M., Kondo, T., Horii, A., Ushijima, T. & Sasaki, H.
Genome-wide profiling of promoter methylation in human.
Oncogene 25, 3059-3064 (2006)
PubMed

Yokomine, T., Hata, K., Tsudzuki, M. & Sasaki, H.
Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting.
Cytogenet. Genome Res. 113 (Special Issue on Genomic Imprinting), 75-80 (2006)
PubMed

Kobayashi, H., Suda, C., Abe, T., Kohara, Y., Ikemura, T. & Sasaki, H.
Bisulfite sequencing and dinucleotide content analysis of 15 imprinted mouse differentially methylated regions (DMRs): paternally methylated DMRs contain less CpGs than maternally methylated DMRs.
Cytogenet. Genome Res. 113 (Special Issue on Genomic Imprinting), 130-137 (2006)
PubMed

Ohhata, T., Hoki, Y., Sasaki, H & Sado, T.
Tsix-deficent X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.
Cytogenet. Genome Res. 113 (Special Issue on Genomic Imprinting), 345-349 (2006)
PubMed

Hata, K., Kusumi, M.,Yokomine,T., Li, E. & Sasaki, H.
Meiotic and epigenetic aberration in Dnmt3L-deficient male germ cells.
Mol. Reprod. Dev. 73, 116-122 (2006)
PubMed

Sado, T., Hoki, Y. & Sasaki, H.
Tsix silences Xist through modification of chromatin structure.
Dev. Cell 9, 159-165 (2005)
PubMed

Cerrato, F., Sparago, A., Zou, X., Dean, W., Bruggemann, M., Sasaki, H., Reik, W. & Riccio, A.
The two domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster.
Hum. Mol. Genet. 14, 503-511 (2005)
PubMed

Yokomine, T., Shirohzu, H., Purbowasito, W., Toyoda, A., Iwama, H., Ikeo, K., Hori, T., Mizuno, S., Tsudzuki, M., Matsuda, Y., Hattori, M., Sakaki, Y. & Sasaki, H.
Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region.
Genome Res. 15, 154-165 (2005)
PubMed

Kaneda, M., Sado, T., Okano, M., Hata, K., Tsujimoto, N., Li, E. & Sasaki, H.
Role of de novo DNA methyltransferases in initiation of genomic imprinting and X-chromosome inactivation.
Cold Spring Harbor Symp. Quant. Biol. 69, 125-129 (2004)
PubMed

Purbowasito, W., Suda, C., Yokomine, T., Zubair, M., Sado, T., Tsutsui, K. & Sasaki, H.
Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7.
DNA Res. 11, 391-407 (2004)
PubMed

Shirohzu, H., Yokomine, T., Sato, C., Kato, R., Toyoda, A., Purbowasito, W., Suda, C., Mukai, T., Hattori, M., Okumura, K., Sakaki, Y. & Sasaki, H.
A 210-kb segment of tandem repeats and retroelements located between imprinted subdomains of mouse distal chromosome 7.
DNA Res. 11, 325-334 (2004)
PubMed

Ohhata, T., Tachibana, M., Tada, M., Tada, T., Sasaki, H., Shinkai, Y. & Sado, T.
X-inactivation is stably maintained in mouse embryos deficient for histone methyltransferase G9a.
Genesis 40, 151-156 (2004)
PubMed

Kaneda, M., Okano, M., Hata, K., Sado, T., Tsujimoto, N., Li, E. & Sasaki, H.
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.
Nature 429, 900-903 (2004)
PubMed

Kubota, T., Furuumi, H., Kamoda, T., Iwasaki, N., Tobita, N., Fujiwara, N., Goto, Y., Matsui, A., Sasaki, H. & Kajii, T.
ICF syndrome in a girl with DNA hypomethylation but without detectable DNMT3B mutation.
Am. J. Med. Genet. 129A, 290-293 (2004)
PubMed

Sado, T., Okano, M., Li, E. & Sasaki, H.
De novo methylation is dispensable for the initiation and propagation of X chromosome inactivation.
Development 131, 957-982 (2004)
PubMed

Ishida, C., Ura, K., Hirao, A., Sasaki, H., Toyoda, A., Sakaki, Y., Niwa, H., Li, E. & Kaneda, Y.
Genomic organization and promoter analysis of the Dnmt3b gene.
Gene 310, 151-159 (2003)
PubMed

Sado, T., Li, E. & Sasaki, H.
Effect of Tsix-disruption on Xist expression in male ES cells.
Cytogenet. Genome Res. 99, 115-118 (2002)
PubMed

Kuroiwa, A., Yokomine, T., Sasaki, H., Tsudzuki, M., Tanaka, K., Namikawa, T. & Matsuda, Y.
Biallelic expression of Z-linked genes in male chickens.
Cytogenet. Genome Res. 99, 310-314 (2002)
PubMed

Shirohzu, H., Kubota, T., Kumazawa, A., Sado, T., Chijiwa, T., Inagaki, K., Suetake, I., Tajima, S., Wakui, K., Miki, Y., Hayashi, M., Fukushima, Y. & Sasaki, H.
Three novel DNMT3B mutations in Japanese patients with ICF syndrome.
Am. J. Med. Genet. 112, 31-37 (2002)
PubMed

Kurosawa, K., Sasaki, H., Sato, Y., Yamanaka, M., Shimizu, M., Ito, Y., Okuyama, T., Matsuo, M., Imaizumi, K., Kuroki, Y. & Nishimura, G.
Paternal UPD14 is responsible for a distinctive malformation complex.
Am. J. Med. Genet. 110, 268-272 (2002)
PubMed

Ishihara, K. & Sasaki, H.
An evolutionarily conserved putative insulator element near the 3’ boundary of the imprinted Igf2/H19 domain.
Hum. Mol. Genet. 11, 1627-1636 (2002)
PubMed

Sotomaru, Y., Katsuzawa, Y., Hatada, I., Obata, Y., Sasaki, H. & Kono, T.
Upregulated expression of the imprinted genes H19 and Igf2r in mouse uniparental fetuses.
J. Biol. Chem. 277, 12474-12478 (2002)
PubMed

Davies, K., Bowden, L., Smith, P., Dean, W., Hill, D., Furuumi, H., Sasaki, H., Cattanach, B. & Reik, W.
Disruption of mesodermal enhancers for Igf2 in the minute mutant.
Development 129, 1657-1668 (2002)
PubMed

Aoki, A., Suetake, I., Miyagawa, J., Fujio, T., Chijiwa, T., Sasaki, H. & Tajima, S.
Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases.
Nucl. Acids Res. 29, 3506-3512 (2001)
PubMed

Yokomine, T., Kuroiwa, A., Tanaka, K., Tsudzuki, M., Matsuda, Y. & Sasaki, H.
Sequence polymorphisms, allelic expression status and chromosomal locations of the chicken IGF2 and MPR1 genes.
Cytogenet. Cell Genet. 93, 109-113 (2001)
PubMed

Hamatani, T., Sasaki, H., Ishihara, K., Hida, N., Maruyama, T., Yoshimura, Y., Hata, J. & Umezawa, A.
Epigenetic mark sequence of the H19 gene in human sperm.
Biochim. Biophys. Acta 1518, 137-144 (2001)
PubMed

Sado, T., Wang, Z., Sasaki, H. & Li, E.
Regulation of imprinted X-chromosome inactivation in mice by Tsix.
Development 128, 1275-1286 (2001)
PubMed

Ohno, M., Aoki, N. & Sasaki, H.
Allele-specific detection of nascent transcripts by fluorescence in situ hybridization reveals temporal and culture-induced changes in Igf2 imprinting during pre-implantation mouse development.
Genes Cells 6, 249-259 (2001)
PubMed

Mizuno, S., Chijiwa, T., Okamura, T., Akashi, K., Fukumaki, Y., Niho, Y. & Sasaki, H.
Expression of DNA methyltransferases DNMT1, 3A and 3B in normal hematopoiesis and in acute and chronic myelogenouse leukemia.
Blood 97, 1172-1179 (2001)
PubMed

Watanabe, T., Yoshimura, A., Mishima, Y., Endo, Y., Shiroishi, T., Koide, T., Sasaki, H., Asakura, H. & Kominami, R.
Differential chromatin packaging of genomic imprinted region between expressed and non-expressed alleles.
Hum. Mol. Genet. 9, 3029-3035 (2000)
PubMed

Ueda, T., Abe, K., Miura, A., Yuzuriha, M., Zubair M., Noguchi, M., Niwa, K., Kawase, Y., Kono, T., Matsuda, Y., Fujimoto, H., Shibata, H., Hayashizaki, Y. & Sasaki, H.
The paternal methylation imprint of the mouse H19 locus is acquired in the gonocyte stage during fetal testis development.
Genes Cells 5, 649-659 (2000)
PubMed

Yatsuki, H., Watanabe, H., Hattori, M., Joh, K., Soejima, H., Komoda, H., Xin, Z., Zhu, X., Higashimoto, K., Nishimura, M., Kuratomi, S., Sasaki, H., Sakaki, Y. & Mukai, T.
Sequence-based structural features between Kvlqt1 and Tapa1 in mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region in human 11p15.5: long-stretches of unusually well conserved intronic sequence of Kvlqt1 between mouse and human.
DNA Res. 7, 195-206 (2000)
PubMed

Ishihara, K., Hatano, N., Furuumi, H., Kato, R., Iwaki, T., Miura, K., Jinno, Y. & Sasaki, H.
Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting.
Genome Res. 10, 664-671 (2000)
PubMed

Kato, R., Shirohzu, H., Yokomine, T., Mizuno, S., Mukai, T. & Sasaki, H.
Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7.
DNA Res. 6, 401-405 (1999)
PubMed

Kato, R. & Sasaki, H.
Quick identification and localization of CpG islands in large genomic fragments by partial digestion with HpaII and HhaI.
DNA Res. 5, 287-295 (1998)
PubMed

Ishihara, K., Kato, R., Furuumi, H., Zubair, M. & Sasaki, H.
Sequence of a 42-kb mouse region containing the imprinted H19 locus: identification of a novel muscle-specific transcription unit showing biallelic expression.
Mamm. Genome 9, 775-777 (1998)
PubMed

Shibata, H., Yoda, Y., Kato, R., Ueda, T., Kamiya, M., Hiraiwa, N., Yoshiki, A., Plass, C., Pearsall, R.S., Held, W.A., Muramatsu, M., Sasaki, H., Kusakabe, M. & Hayashizaki, Y.
A methylation imprint mark in the imprinted gene Grf1/Cdc25Mm locus shares a common feature with the U2afbp-rs gene: an association with a short tandem repeat and a hypermethylated region.
Genomics 49, 30-37 (1998)
PubMed

Hatano, N., Eversole-Cire, P., Ferguson-Smith, A.C., Jones, P.A., Surani, M.A. & Sasaki, H.
Enhancer-dependent, locus-wide regulation of the imprinted mouse insulin-like growth factor II gene.
J. Biochem. 123, 984-991 (1998)
PubMed

Moore, T., Constancia, M., Zubair, M., Bailleul, B., Feil, R., Sasaki, H. & Reik, W.
Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.
Proc. Natl. Acad. Sci. USA 94, 12509-12514 (1997)
PubMed

Hayashida, T., Eversole-Cire, P., Jones, P.A. & Sasaki, H.
Imprinted genes are up-regulated by growth arrest in embryonic fibroblasts.
J. Biochem. 122, 901-903 (1997)
PubMed

Zubair, M., Hilton, K., Saam, J.R., Surani, M.A., Tilghman, S.M. & Sasaki, H.
Structure and expression of the mouse L23mrp gene downstream of the imprinted H19 gene: biallelic expression and lack of interaction with the H19 enhancers.
Genomics 45, 290-296 (1997)
PubMed

Sasaki, H., Shimozaki, K., Zubair, M., Aoki, N., Ohta, K., Hatano, N., Moore, T., Feil, R., Constancia, M., Reik, W. & Rotwein, P.
Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene.
DNA Res. 3, 331-335 (1996)
PubMed

Plass, C., Shibata, H., Kalcheva, I., Mullins, L., Kotelevtseva, N., Mullins, J., Kato, R., Sasaki, H., Hirotsune, S., Okazaki, Y., Held, W.A., Hayashizaki, Y. & Chapman, V.M.
Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS-M.
Nature Genet. 14, 106-109 (1996)
PubMed

Sasaki, H., Ferguson-Smith, A.C., Shum, A.S.W., Barton, S.C. & Surani, M.A.
Temporal and spatial regulation of H19 imprinting in normal and uniparental embryos.
Development 121, 4195-4202 (1995)
PubMed

Tada, M., Tada, T., Takagi, N., Hayashizaki, Y., Shibata, H., Hirotsune, S., Okazaki, Y., Muramatsu, M., Sasaki, H., Ueda, T. & Chapman, V.M.
Localization of mouse imprinted gene U2af1-rs1 to A3.2-4 band of chromosome 11 by FISH.
Mamm. Genome 5, 655 (1994)
PubMed

Sumimoto, H., Kage, Y., Nunoi, H., Sasaki, H., Nose, T., Fukumaki, Y., Ohno, M., Minakami, S. & Takeshige, K.
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
Proc. Natl. Acad. Sci. USA 91, 5345-5349 (1994)
PubMed

Hayashizaki, Y., Shibata, H., Hirotsune, S., Sugino, H., Okazaki, Y., Sasaki, N., Hirose, K., Imoto, H., Okuizumi, H., Muramatsu, M., Komatsubara, H., Shiroishi, T., Moriwaki, K., Matsuki, M., Hatano, N., Sasaki, H., Ueda, T., Mise, N., Takagi, N., Plass, C. & Chapman, V.M.
Identification and characterization of an imprinted U2af binding protein related sequence on mouse chromosome 11 detected by efficient genomic screening using restriction landmark genomic scanning (RLGS-M).
Nature Genet. 6, 33-40 (1994)
PubMed

Eversole-Cire, P., Ferguson-Smith, A.C., Sasaki, H., Brown, K., Cattanach, B.M., Gonzales, F.A., Surani, M.A. & Jones, P.A.
Activation of an imprinted Igf2 gene in mouse somatic cell cultures.
Mol. Cell. Biol. 13, 4928-4938 (1993)
PubMed

Hamada, T., Sasaki, H., Seki, R. & Sakaki, Y.
Mechanism of chromosomal integration of transgenes in microinjected mouse eggs: sequence analysis of genome-transgene and transgene-transgene junctions at two loci.
Gene 128, 197-202 (1993)
PubMed

Ferguson-Smith, A.C., Sasaki, H., Cattanach, B.M. & Surani, M.A.
Parental-origin-specific epigenetic modification of the mouse H19 gene.
Nature 362, 751-755 (1993)
PubMed

Sasaki, H., Jones, P.A., Chaillet, J.R., Ferguson-Smith, A.C., Barton, S.C., Reik, W. & Surani, M.A.
Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.
Genes Dev. 6, 1843-1856 (1992)
PubMed

Ueda, T., Yamazaki, K., Suzuki, R., Fujimoto, H., Sasaki, H., Sakaki, Y. & Higashinakagawa, T.
Parental methylation patterns of a transgene locus in adult somatic tissues are imprinted during gametogenesis.
Development 116, 831-839 (1992)
PubMed

Ogawa, T., Oda, N., Nakashima, K., Sasaki, H., Hattori, M., Sakaki, Y., Kihara, H. & Ohno, M.
Unusually high conservation on untranslated sequences in cDNAs for Trimeresurus flavoviridis phospholipase A2 isozymes.
Proc. Natl. Acad. Sci. USA 89, 8557-8561 (1992)
PubMed

Kira, J., Koyanagi, Y., Yamada, T., Itoyama, Y., Goto, I., Yamamoto, M., Sasaki, H. & Sakaki, Y.
Increased HTLV-I-associated myelopathy: a quantitative PCR study.
Ann. Neurol. 29, 194-201 (1991)
PubMed

Furuya H., Saraiva, M.J.M., Gawinowicz, M.A., Alves, I.L., Costa, P.P., Sasaki, H., Goto, I. & Sakaki, Y.
Production of recombinant human transthyretin with biological activities towards the understanding of the molecular basis of familial amyloidotic poluneuropathy (FAP).
Biochemistry 30, 2415-2421 (1991)
PubMed

Sasaki, H., Hamada, T., Ueda, T., Seki, R., Higashinakagawa, T. & Sakaki, Y.
Inherited type of allelic methylation variations in a mouse chromosome region where an integrated transgene shows methylation imprinting.
Development 111, 573-581 (1991)
PubMed

原著論文  Original Research Papers / 和文 Japanese  (1990年以前は省略)
池松秀之, 鄭湧, 白根健次郎, 藤英博, 佐々木裕之, 松本信也, 野田望, 堀田多恵子, 内海健, 康東天
2014/15年流行期に患者より分離されたインフルエンザA/H3N2, Bウイルスのノイラミニダーゼ遺伝子と薬剤感受性との関連についての検討
福岡医学雑誌 107, 98-104 (2016)

池松秀之, 鄭湧, 白根健次郎, 藤英博, 佐々木裕之, 古賀結, 浦田美秩代, 堀田多恵子, 内海健, 康東天
2013/14流行期に患者より分離されたインフルエンザA/H1N1pdm09, A/H3N2, Bウイルスのノイラミニダーゼ遺伝子と薬剤感受性との関連についての検討
福岡医学雑誌 106, 231-239 (2015)
PubMed

池松秀之, 鄭湧, 白根健次郎, 藤英博, 佐々木裕之, 古賀結, 浦田美秩代, 堀田多恵子, 内海健, 康東天
2011/12及び2012/13年インフルエンザ流行期に患者より分散されたA/H3N2型ウイルス96株のNA遺伝子配列と薬剤感受性との関連についての検討
福岡医学雑誌 106, 16-22 (2015)
PubMed

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総説 Reviews / 英文 English  (1990年以前は省略)
Tucci, V., Isles, A., Kelsey, G., Ferguson-Smith, A.C. & The Erice Imprinting Group.
Genomic imprinting and physiological processes in mammals.
Cell 176, 952-965 (2019)
PubMed

Stunnenberg, H.G., The International Human Epigenome Consortium & Hirst, M.
The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery.
Cell 167, 1145-1149 (2016)
PubMed

Tomizawa, S. & Sasaki, H.
Genomic imprinting and its relevance to congenital disease, infertility, molar pregnancy and induced pluripotent stem cells
J. Hum. Genet. 57, 84-91 (2012)
PubMed

Li, Y. & Sasaki, H.
Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming
Cell Res. 21, 466-473 (2011)
PubMed

Sasaki, H. & Matsui, Y.
Epigenetic events in mammalian germ-cell development: reprogramming and beyond.
Nat. Rev. Genet. 9, 129-140 (2008)
PubMed

Kato, Y. & Sasaki, H.
Imprinting and looping: epigenetic marks control interactions between regulatory elements.
BioEssays 27, 1-4 (2005)
PubMed

Hata, K. & Sasaki, H.
Genomic imprinting: mechanisms, significance and evolution.
J. Mamm. Ova Res. 20, 64-68 (2003)
PubMed

Sasaki, H., Ishihara, K. & Kato, R.
Mechanisms of Igf2/H19 imprinting: DNA methylation, chromatin and long-distance gene regulation.
J. Biochem. 127, 711-715 (2000)
PubMed

Nakao, M. & Sasaki, H.
Genomic imprinting: significance in development and diseases and the molecular mechanisms.
J. Biochem. 120, 467-473 (1996)
PubMed

Reik, W., Sasaki, H., Ferguson-Smith, A.C., Feil, R., Bowden, L., Penberth, J., Surani, M.A., Gurtmann, I. & Klose, J.
Parental imprinting and epigenetic programming of the mouse genome: long lasting consequences for development and phenotype.
Chromosome Today 11, 367-376 (1993)
PubMed

Surani, M.A., Sasaki, H., Ferguson-Smith, A.C., Allen, N.D., Barton, S.C. Jones, P.A. & Reik, W.
The inheritance of germline-specific epigenetic modifications during development.
Phil. Trans. R. Soc. Lond. B 339, 165-172 (1993)
PubMed

Surani, M.A., Sasaki, H., Barton, S.C. & Ferguson-Smith, A.C.
Germline-specific programming of parental genomes for development.
Sem. Dev. Biol. 4, 199-206 (1993)
PubMed

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総説 Reviews / 和文 Japanese  (1990年以前は省略)
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千葉初音, 佐々木裕之
ゲノムインプリンティングとiPS細胞
医学のあゆみ (第5土曜特集)次世代iPS医療 239, 1265-1269 (2011)

佐渡敬, 佐々木裕之(監修)
特集ノンコーディングRNAによるエピジェネティック制御機構
細胞工学 30, 7 (2011)

佐々木裕之
進化する細胞のちから 遺伝子ですべては決まらない!注目されるエピジェネティクス
ヘルシスト 3(2), 12-15 35(2), 12-15 (2011)

千葉初音, 佐々木裕之
ゲノムインプリンティング:ゲノムに刻まれた親の記憶と個体発生
実験医学 28 (増刊号), 68-73 (2010)

佐々木裕之
エピジェネティクスとは何か?
発達障害白書 2011年版 2, 39-40 (2010)

山本耕裕, 佐々木裕之
卵子における不思議な遺伝子発現制御と小分子RNA
日本生殖内分泌学会雑誌 15, 53-54 (2010)

一柳健司, 佐々木裕之
ゲノムワイドなDNAメチル化解析
分子細胞治療 8, 372-376 (2009)

李玉鳳, 佐々木裕之
生命現象と疾患のメカニズムを理解する鍵 -エピジェネティクス入門-
Biophilia 5, 6-10 (2009)

佐渡敬, 佐々木裕之
哺乳類のエピジェネティクス
生物の科学:遺伝 63, 65 - 70 (2009)

豊田敦, 佐々木裕之
個人ゲノム解読
The Mainichi Medical Journal 5, 196-198 (2009)

佐々木裕之, 北條浩彦
機能性小分子RNAの大規模シークエンス
実験医学 27, 14-19 (2009)

千葉初音, 佐々木裕之
バイサルファイトシークエンシング
実験医学別冊 注目のバイオ実験シリーズ エピジェネティクス実験プロトコール 38-47 (2008)

平澤竜太郎, 佐々木裕之
ゲノムインプリンティング
生体の科学 59, (増大 特集) 現代医学・生物学の仮説・学説2008, 59, 402-403 (2008)

渡部聡朗, 佐々木裕之. カレントトピックス
マウス卵子において内在性siRNAは自然に形成される二本鎖RNAから作られ、転写物を制御している
実験医学 26, 2109-2111 (2008)

古海弘康, 佐々木裕之
遺伝か環境か? エピジェネティクスの視点から
医学のあゆみ 臨床ゲノム研究-成果と課題 225, 949-953 (2008)

古海弘康, 佐々木裕之
エピジェネティクス―疾患を見つめる新たな視点
BIO Clinica 23, 155-159 (2008)

富澤信一, 佐々木裕之
細胞のエピジェネティクス
遺伝子医学MOOK (別冊) 進みつづける細胞移植治療の実際 上巻, 145-148 (2008)

佐々木裕之, 熊木健治, 小林久人, 加藤譲, 平澤竜太郎
バイサルファイト法によるDNAメチル化解析の落とし穴 (クローズアップ実験法)
実験医学 25, 2191-2196 (2007)

佐々木裕之, 石野史敏, 牛島俊和, 久保田健夫
エピジェネティクスがもたらす可能性
科学 77, 75-81 (2007)

佐々木裕之, 富澤信一
エピジェネティクスの話 三毛猫の模様からがん治療まで
ファルマシア 43, 310-314 (2007)

渡部聡朗、竹田篤史
マウス生殖細胞で発現するpiRNAとsiRNA
実験医学 25, 800-805 (2007)

金田正弘,佐々木裕之
生殖細胞とゲノムインプリンティング
実験医学 24 (増刊号) エピジェネティクス医科学: 生命のプログラムを解読する,1166-1171

鈴木智弘,佐々木裕之
ゲノムDNAメチル化解析法
細胞工学別冊 実験プロトコールシリーズ マウス表現型解析プロトコール.160-166 (2006)

佐々木裕之
進化を促すエピジェネティクス
現代思想(特集・進化論), 34-2, 112-118, 青土社(2006)

秦健一郎, 佐々木裕之
生殖系列におけるインプリント成立機構
Molecular Medicine 42, 158-163 (2005)

佐々木裕之
ゲノムインプリンティング: 新しい潮流をもたらしたスーパーモデル (Overview)
Molecular Medicine 42, 146-148 (2005)

熊木健治, 佐々木裕之
幹細胞とゲノムインプリンティング
バイオインダストリー 22 (2), 29-34 (2005)

古海弘康, 佐々木裕之
シリーズ最新医学講座・転写因子12: エピジェネティクス制御とその異常
臨床検査 48, 1673-1679 (2004)

金田正弘, 佐々木裕之
HOT PRESS: DNAメチル化酵素Dnmt3aが生殖系列でゲノム刷り込み(インプリンティング)を行う
細胞工学 23, 934-935 (2004)

石原宏, 佐々木裕之, 中尾光善
クロマチンインスレーターの構造と機能
わかる実験医学シリーズ 注目のエピジェネティクスがわかる 63-70 (2004)

佐々木裕之
エピジェネティクスと疾患
Molecular Medicine 41 (増刊号) ヒトゲノム-ヒトの理解と疾病の克服 332-338 (2004)

金田正弘, 佐渡敬, 佐々木裕之
遺伝子に刷り込まれた記憶: 細胞分化とDNAメチル化・ゲノムインプリンティング
遺伝 58, 69-74 (2004)

金田正弘, 佐々木裕之
DNAメチル化とクロマチンによるゲノムインプリンティング制御機構
生体の科学 54, 206-210 (2003)

秦健一郎, 佐々木裕之
ゲノム刷り込みのファンダメンタルズ
現代医療 35, 965-970 (2003)

金田正弘, 熊木健治, 佐々木裕之
ゲノムインプリンティング
Molecular Medicine 40 (増刊号) 再生医学, 18-24 (2003)

佐々木裕之
ゲノムインプリンティング、X染色体不活性化とDNAメチル化
蛋白質・核酸・酵素 47, 1822-1828 (2002)

河野友宏, 佐々木裕之, 中辻憲夫
クローン動物の頻発異常とエピジェネティクス-序論
蛋白質・核酸・酵素 47, 1785-1787 (2002)

石原宏,佐々木裕之
ゲノムインプリンティングの分子メカニズム
医学のあゆみ 202, 217-220 (2002)

佐々木裕之
ゲノムインプリンティング-はじめに
医学のあゆみ 202, 215 (2002)

辻本直美,佐々木裕之
ゲノムインプリンティングとエピジェネティック修飾機構
実験医学 20 (増刊号) ゲノム機能を担う核・染色体のダイナミクス, 1583-1587 (2002)

佐々木裕之
親から子に引き継がれる遺伝的要因: ゲノム刷り込みの影響
科学 72, 309-314, (2002)

佐々木裕之
エピジェネティクス: ゲノム修飾による哺乳動物発生の調節機構
医学のあゆみ 199, 841-845 (2001)

佐々木裕之
ゲノムインプリンティング領域と関連疾患へのゲノムからのアプローチ
蛋白質・核酸・酵素 46 (増刊号) ゲノムサイエンスの新たなる挑戦, 2342-2345 (2001)

佐渡敬, 佐々木裕之
ほ乳類の発生におけるDNAメチル化の役割
細胞工学 20, 351-355 (2001)

佐渡敬, 佐々木裕之
生殖遺伝学とインプリンティング
病理と臨床 18, 1223-1226 (2000)

佐々木裕之
ゲノムインプリンティングと疾患
実験医学 18, 1076-1080 (2000)

佐々木裕之
ゲノムインプリンティングとクロマチン構造
蛋白質・核酸・酵素 44 (増刊号) 細胞核研究の最先端, 1691-1697 (1999)

佐々木裕之
ゲノムインプリンティングと染色体機能ドメイン
蛋白質・核酸・酵素 43, 2101-2108 (1998)

水野晋一, 佐々木裕之
ゲノムインプリンティング: ヒトとマウスの分子遺伝学的研究からみたそのメカニズム
遺伝子医学 2, 406-411 (1998)

佐々木裕之
インプリンティングのメカニズムとDNAメチル化
Molecular Medicine 35, 888-896 (1998)

波多野直哉, 佐々木裕之
ゲノム刷込みと哺乳類の胚発生
蛋白質・核酸・酵素 43 (増刊号) 生殖細胞の発生と性分化, 541-548 (1998)

加藤玲子, 佐々木裕之
DNA (cytosine-5)-methyltransferase.
Molecular Medicine 34 (臨時増刊号) ノックアウトマウス・データブック, 141-142 (1997)

佐々木裕之
インプリンティング研究の最近の進展: 染色体ドメインレベルの転写制御と翻訳されないRNA
蛋白質・核酸・酵素 40, 1956-1957 (1995)

佐々木裕之, 浜田剛
ゲノムインプリンティングのモデルマウス
Molecular Medicine (臨時増刊号) マニュアル・疾患モデルマウス, 82-87 (1994)

佐々木裕之
ゲノムインプリンティングの進化をめぐって: 表現型・分子機構からの考察
細胞工学 13, 1020-1025 (1994)

佐々木裕之
成長因子遺伝子とゲノムインプリンティングの進化
細胞工学 13, 589-594 (1994)

佐々木裕之
ゲノムインプリンティングの分子機構
実験医学 12, 1122-1126 (1994)

佐々木裕之
哺乳類ゲノムのインプリンティング: 個体発生・細胞分化への影響と分子機構
生化学 64, 1225-1243 (1992)

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著書 Books / 英文 English
Unoki, M. & Sasaki, H.
ICF syndrome.
Encyclopedia of Cancer 1-5, Springer Berlin Heidelberg (2015)

著書 Books / 和文 Japanese  (1990年以前は省略)
鵜木元香, 佐々木裕之
第5章: 生殖細胞形成と個体発生におけるエピジェネティクス
エピジェネティクスの産業応用 (畑田出穂, 久保田健夫監修), 78-89, シーエムシー出版 (2014)

鵜木元香, 佐々木裕之
第2部-4: 生殖・発生
エピジェネティクスキーワード事典 (牛島俊和, 真貝洋一編), 123-129, 羊土社 (2013)

佐々木裕之
2章:エピジェネティクス-DNAメチル化酵素の重要性
英語論文セミナー: 21世紀の分子生物学 (渡辺公綱, 桂勲編), 22-36, 講談社 (2013)

佐々木裕之
第22-17〜19章: エピジェネティクス, DNAメチル化, ゲノムインプリンティング
進化学事典 (日本進化学会編), 753-759, 共立出版 (2012)

佐々木裕之
第III-9章: エピジェネティクスの分子機構
卵子学 (森崇英総編集), 103-109, 京都大学学術出版会 (2011)

佐々木裕之
4章: ゲノムの高度活用戦略―エピジェネティクス
現代生物科学入門1 (浅島誠,黒岩常祥,小原雄治 編), 153-200, 岩波書店 (2009)

平澤竜太郎, 佐々木裕之
生殖細胞分化とエピジェネティクス
転写制御の分子生物学-ゲノムでコードに向けて (加藤茂明編), 63-72, 南山堂 (2008)

久須美真紀, 佐々木裕之
生殖・発生とエピジェネティクス
図説ARTマニュアル(改訂第2版) (森崇英, 久保春海, 岡村均 編), 492-496,永井書店 (2006)

平澤竜太郎, 佐々木裕之
第6章 DNAメチル化. 再生医療教科書シリーズ
第3巻 「再生医療のための分子生物学(仲野徹・赤池敏宏 監修)」 80-96,コロナ社(2006)

佐々木裕之
エピジェネティクス入門 −三毛猫の模様はどう決まるのか−
岩波科学ライブラリー 岩波書店(2005)

佐々木裕之編
エピジェネティクス
Springer Reviews シリーズ シュプリンガー・フェアラーク東京(2004)

佐渡敬, 佐々木裕之
性染色体の構造と機能
Springer Reviews シリーズ クロマチンと遺伝子機能制御 (堀越正美編), 15-24, シュプリンガー・フェアラーク東京 (2003)

横峯孝昭, 佐々木裕之
ゲノムインプリンティングの進化
Springer Reviews シリーズ ゲノムからみた生物の多様性と進化 (五條堀孝編), 164-170, シュプリンガー・フェアラーク東京 (2003)

佐々木裕之
単為発生とゲノムインプリンティング (第7章)
バイオサイエンスの新世紀 第14巻「生命工学: 新しい生命へのアプローチ (浅島誠・山村研一編)」, 200-208, 共立出版 (2002)

佐々木裕之
インプリンティング (第9章)
岩波講座-現代医学の基礎 第5巻「生殖と発生 (森崇英・山村研一編)」, 183-194, 岩波書店 (1999)

佐々木裕之
新しい遺伝概念「ゲノム刷り込み」と疾患
内科学進歩のトピックス (仁保喜之・石橋大海編), 6-8, 九州大学出版会 (1998)

佐々木裕之
23章 分子細胞遺伝学,C. ゲノム刷り込み現象
人類遺伝学 (柳瀬敏幸編), 226-230, 金原出版 (1995)

佐々木裕之
ゲノム刷り込み現象
臨床DNA診断法 (古庄敏行・井村裕夫・中込弥男・岡田伸太郎・湯浅保仁・倉田毅編), 22-24, 金原出版 (1995)

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