九州大学 生体防御医学研究所

下記の通り、Makoto Taniguchi 先生によるセミナーを開催します。皆様のご来聴を心より歓迎致します。


※セミナーは英語で行われます。(Seminar in English)

演題 / Title

A long non-coding enhancerRNA forms Triple-strand genome structure, R-loops, to shape emotional experience-induced behavioral adaptation

演者 / Speaker

Makoto Taniguchi (Ph.D.)
Assistant Professor
Department of Neuroscience, Medical University of South Carolina

日時 / Date

２０２４年５月２８日（火） /　May. 28 (Tue), 2024
16：00〜17：00

場所 / Venue

病院キャンパス 生体防御医学研究所 本館 1階 会議室
以下の地図の30番です。
キャンパスマップ

Seminar Room, Main Building 1F, Medical Institute of Bioregulation, Hospital Campus
No.30 on the following linked map.
Campus Map

要 旨 / Abstract

Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experience-dependent activation of immediate-early response genes, such as Npas4. We discovered that a conserved, long non-coding enhancer RNA (lnc-eRNA) transcribed from an activity-sensitive enhancer produces RNA:DNA hybrid R-loop structures that support 3D chromatin-looping of the enhancer and proximal promoter and stimulus-induced, rapid Npas4 gene induction. We also show that this Npas4 lnc-eRNA is required for the development of behavioral adaptations produced by chronic psychosocial stress or cocaine exposure, revealing a critical role for this new genomic regulatory mechanism in the transmission of emotional experiences, such as stress or drug use, to adaptive behavioral responses.

参考論文 / References

1. Chao Y.S. et al.
   Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats. Cell Report 42(5):112404, 2023.
2. Hughes B.W. et al.
   NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses. Elife 12:e75631, 2023.
3. Taniguchi M. et al.
   HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. Neuron 96:130-144, 2017.
4. Smith L.N. et al.
   Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration. Neuron 82:645-658, 2014.

連絡先 / Contact

高等研究院 / 生体防御医学研究所（脳機能分子システム分野）
高野　哲也
092 (642) 4201

Institute for Advanced Study / Medical Institute of Bioregulation
Tetsuya Takano
TEL: 092 (642) 4201