{"id":302,"date":"2025-04-01T00:18:34","date_gmt":"2025-04-01T00:18:34","guid":{"rendered":"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp\/?post_type=service&#038;p=302"},"modified":"2025-07-21T03:26:20","modified_gmt":"2025-07-21T03:26:20","slug":"paper-18","status":"publish","type":"service","link":"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/publication\/paper-18\/","title":{"rendered":"bioRxiv 2024 (Hirotani, Kunimura et al.)"},"content":{"rendered":"\n<p>Cholesterol sulfate prevents maternal\u2013fetal conflict by locally modulating immune reactivity.<\/p>\n\n\n\n<p><strong>Hirotani K<\/strong>*, <strong>Kunimura K<\/strong>*<sup>\u2020<\/sup>, Maeda R, Sugiura Y, Nakata K, Takahashi M, Izumi Y, <strong>Akiyoshi S<\/strong>, <strong>Matsubara K<\/strong>, <strong>Morino K<\/strong>, Iwasaki T, Tanaka K, Aulia F, Miyata K, Hosokawa T, Mori T, Ohkawa Y, Bamba T, Toh H, Sasaki H, Oda Y, <strong>Uruno T<\/strong>, Kato K, <strong>Fukui Y<\/strong><sup>\u2020<\/sup> (*co-first authors; <sup>\u2020<\/sup>corresponding author):<\/p>\n\n\n\n<p><strong>bioRxiv<\/strong>, <strong>2024<\/strong>.&nbsp;<\/p>\n\n\n\n<p>Although placental mammals are at high risk of maternal\u2013fetal immune conflict, it is unclear how the semi-allogeneic fetus avoids rejection. Cholesterol sulfate (CS) is a bioactive metabolite that inhibits leukocyte migration and activation. This study investigated the roles and cells associated with CS in pregnant mice and humans. CS was sequentially produced by maternal-derived endometrial cells and fetal-derived placental trophoblasts before and after placentation. When mated with allogeneic males, CS-deficient mice showed increased fetal resorption rates under induced placental inflammation. This phenotype disappeared when the activity of the CS-producing enzyme was restored in the placenta. Placental CS levels were reduced in patients with \u201cvillitis of unknown etiology.\u201d Thus, we uncovered the spatiotemporal control of CS production and its relevance to local immunosuppression during pregnancy.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.10.11.617779v1.full\">https:\/\/www.biorxiv.org\/content\/10.1101\/2024.10.11.617779v1.full<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"968\" src=\"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp\/wp-content\/uploads\/2025\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-10-10-18.16.42-1024x968.jpg\" alt=\"\" class=\"wp-image-303\" style=\"width:521px;height:auto\" srcset=\"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp\/wp-content\/uploads\/2025\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-10-10-18.16.42-1024x968.jpg 1024w, https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp\/wp-content\/uploads\/2025\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-10-10-18.16.42-300x284.jpg 300w, https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp\/wp-content\/uploads\/2025\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-10-10-18.16.42-768x726.jpg 768w, https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp\/wp-content\/uploads\/2025\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-10-10-18.16.42-1536x1452.jpg 1536w, https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp\/wp-content\/uploads\/2025\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-10-10-18.16.42.jpg 1930w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"featured_media":303,"template":"","service_category":[8],"class_list":["post-302","service","type-service","status-publish","has-post-thumbnail","hentry","service_category-original-paper"],"_links":{"self":[{"href":"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp-json\/wp\/v2\/service\/302","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp-json\/wp\/v2\/service"}],"about":[{"href":"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp-json\/wp\/v2\/types\/service"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp-json\/wp\/v2\/media\/303"}],"wp:attachment":[{"href":"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp-json\/wp\/v2\/media?parent=302"}],"wp:term":[{"taxonomy":"service_category","embeddable":true,"href":"https:\/\/bioreg.kyushu-u.ac.jp\/labo\/iden\/wp-json\/wp\/v2\/service_category?post=302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}