Porter, D.W., Yakushiji, H., Nakabeppu, Y., Sekiguchi, M., Fivash, M.J., Jr. and Kasprzak, K.S. (1997) Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II). Carcinogenesis, 18, 1785-1791.
Yakushiji, H., Maraboeuf, F., Takahashi, M., Deng, Z.S., Kawabata, S., Nakabeppu, Y. and Sekiguchi, M. (1997) Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity. Mutat. Res., 384, 181-194.
Oda, H., Nakabeppu, Y., Furuichi, M. and Sekiguchi, M. (1997) Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products. J. Biol. Chem., 272, 17843-17850.
Chen, J., Kelz, M.B., Hope, B.T., Nakabeppu, Y. and Nestler, E.J. (1997) Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments. J. Neurosci., 17, 4933-4941.
Hollen, K.M., Nakabeppu, Y. and Davies, S.W. (1997) Changes in expression of DFosB and the Fos family proteins following NMDA receptor activation in the rat striatum. Mol. Brain. Res., 47, 31-43.
Cai, J.P., Kawate, H., Ihara, K., Yakushiji, H., Nakabeppu, Y., Tsuzuki, T. and Sekiguchi, M. (1997) Significance of the conserved amino acid sequence for human MTH1 protein with antimutator activity. Nucleic Acids Res., 25, 1170-1176.
Goto, H., Motomura, S., Wilson, A.C., Freiman, R.N., Nakabeppu, Y., Fukushima, K., Fujishima, M., Herr, W. and Nishimoto, T. (1997) A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function. Genes Dev., 11, 726-737.
Sekiguchi,
M., Nakabeppu, Y., Sakumi, K. and Tuzuki, T. (1996) DNA-repair methyltransferase
as a molecular device for preventing mutation and cancer. J Cancer Res
Clin Oncol, 122, 199-206.
Otsuka,
M., Abe, M., Nakabeppu, Y., Sekiguchi, M. and Suzuki, T. (1996) Polymorphism
in the human O6-methylguanine-DNA methyltransferase gene detected by PCR-SSCP
analysis. Pharmacogenetics, 6, 361-363.
Yamagata,
Y., Kato, M., Odawara, K., Tokuno, Y., Nakashima, Y., Matsushima, N.,
Yasumura, K., Tomita, K., Ihara, K., Fujii, Y., Nakabeppu, Y., Sekiguchi,
M. and Fujii, S. (1996) Three-dimensional structure of a DNA repair
enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli. Cell,
86, 311-319.
Vahid-Ansari,
F., Nakabeppu, Y. and Robertson, G.S. (1996) Contrasting effects of
chronic clozapine, Seroquel(TM) (ICI 204,636) and haloperidol administration
of Delta-FosB-like immunoreactivity in the rodent forebrain. Eur. J. Neurosci.,
8, 927-936.
Shimizu,
R., Komatsu, N., Nakamura, Y., Nakauchi, H., Nakabeppu, Y. and Miura,
Y. (1996) Role of c-jun in the inhibition of erythropoietin receptor-mediated
apoptosis. Biochem. Biophys. Res. Commun., 222, 1-6.
Taketomi,
A., Nakabeppu, Y., Ihara, K., Hart, D.J., Furuichi, M. and Sekiguchi,
M. (1996) Requirement for two conserved cysteine residues in the Ada
protein of Escherichia coli for transactivation of the ada promoter. Mol.
Gen. Genet., 250, 523-532.
Doucet,
J.P., Nakabeppu, Y., Bedard, P.J., Hope, B.T., Nestler, E.J., Jasmin,
B.J., Chen, J.S., Iadarola, M.J., St-Jean, M., Wigle, N., Blanchet, P.,
Grondin, R. and Robertson, G.S. (1996) Chronic alterations in dopaminergic
neurotransmission produce a persistent elevation of Delta-FosB-like protein(s)
in both the rodent and primate striatum. Eur. J. Neurosci., 8, 365-381.
Maki, H., Nakabeppu, Y., and Sekiguchi, M. (1996) DNA Replication and
Transcription. In Meyers, R.A. (ed.), Encyclopedia of Molecular Biology
and Molecular Medicine. VCH Publishers Inc, New Yorkpp. pp.86-pp.96.
Nakabeppu, Y., Maki, H. and Sekiguchi, M. (1996) DNA Replication and Transcription.
In Meyers, R.A. (ed.), Molecular Biology and Biotechnology: A Comprehensive
Desk Reference. VCH Publishers Inc, New Yorkpp. pp.234-pp.238.
Chen,
J., Nye, H.E., Kelz, M.B., Hiroi, N., Nakabeppu, Y., Hope, B.T. and Nestler,
E.J. (1995) Regulation of Delta FosB and FosB-like proteins by electroconvulsive
seizure and cocaine treatments. Mol. Pharmacol., 48, 880-889.
Wu,
C., Nagasaki, H., Maruyama, K., Nakabeppu, Y., Sekiguchi, M. and Yuasa,
Y. (1995) Polymorphisms and probable lack of mutation in a human mutT
homolog, hMTH1, in hereditary nonpoliposis colorectal cancer. Biochem.
Biophys. Res. Commun., 214, 1239-1245.
Tsuji,
Y., Akebi, N., Lam, T.K., Nakabeppu, Y., Torti, S.V. and Torti, F.M.
(1995) FER-1, an enhancer of the ferritin H gene and a target of E1A-mediated
transcriptional repression. Mol. Cell. Biol., 15, 5152-5164.
Tanaka,
K., Iwamoto, Y., Ito, Y., Ishibashi, T., Nakabeppu, Y., Sekiguchi, M.
and Sugioka, Y. (1995) Cyclic AMP-regulated synthesis of the tissue
inhibitors of metalloproteinases suppresses the invasive potential of
the human fibrosarcoma cell line HT1080. Cancer Res., 55, 2927-2935.
Kang,
D., Nishida, J., Iyama, A., Nakabeppu, Y., Furuichi, M., Fujiwara, T.,
Sekiguchi, M. and Takeshige, K. (1995) Intracellular localization
of 8-oxo-dGTPase in human cells, with special reference to the role of
the enzyme in mitochondria. J. Biol. Chem., 270, 14659-14665.
Oda,
S., Nishida, J., Nakabeppu, Y. and Sekiguchi, M. (1995) Stabilization
of cyclin E and cdk2 mRNAs at G1/S transition in Rat-1A cells emerging
from the G0 state. Oncogene, 10, 1343-1351.
Furuichi,
M., Yoshida, M.C., Oda, H., Tajiri, T., Nakabeppu, Y., Tsuzuki, T. and
Sekiguchi, M. (1994) Genomic structure and chromosome location of
the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention
of A:T to C:G transversion. Genomics, 24, 485-490.
Hope,
B.T., Nye, H.E., Kelz, M.B., Self, D.W., Iadarola, M.J., Nakabeppu, Y.,
Duman, R.S. and Nestler, E.J. (1994) Induction of a long-lasting AP-1
complex composed of altered Fos-like proteins in brain by chronic cocaine
and other chronic treatments. Neuron, 13, 1235-1244.
Ishibashi,
T., Nakabeppu, Y., Kawate, H., Sakumi, K., Hayakawa, H. and Sekiguchi,
M. (1994) Intracellular localization and function of DNA repair methyltransferase
in human cells. Mutat. Res., 315, 199-212.
Iyama,
A., Sakumi, K., Nakabeppu, Y. and Sekiguchi, M. (1994) A unique structural
feature of rabbit DNA repair methyltransferase as revealed by cDNA cloning.
Carcinogenesis, 15, 627-633.
Ishibashi,
T., Nakabeppu, Y. and Sekiguchi, M. (1994) Artificial control of nuclear
translocation of DNA repair methyltransferase. J. Biol. Chem., 269, 7645-7650.
Nakazawa,
K., Karachot, L., Nakabeppu, Y. and Yamamori, T. (1993) The conjunctive
stimuli that cause long-term desensitization also predominantly induce
c-Fos and Jun-B in cerebellar Purkinje cells. Neuroreport, 4, 1275-1278.
Nakabeppu,
Y., Oda, S. and Sekiguchi, M. (1993) Proliferative activation of quiescent
Rat-1A cells by Delta-FosB. Mol. Cell. Biol., 13, 4157-4166.
Murphy,
T.H., Worley, P.F., Nakabeppu, Y., Christy, B., Gastel, J. and Baraban,
J.M. (1991) Synaptic regulation of immediate early gene expression
in primary cultures of cortical neurons. J. Neurochem., 57, 1862-1872.
Worley,
P.F., Christy, B.A., Nakabeppu, Y., Bhat, R.V., Cole, A.J. and Baraban,
J.M. (1991) Constitutive expression of zif268 in neocortex is regulated
by synaptic activity. Proc. Natl. Acad. Sci. U. S. A., 88, 5106-5110.
Nakabeppu,
Y. and Nathans, D. (1991) A naturally occurring truncated form of
FosB that inhibits Fos/Jun transcriptional activity. Cell, 64, 751-759.
Nathans, D., Christy, B.A., DuBois, R., Lanahan, A., Sanders, L. and
Nakabeppu, Y. (1991) Transcription Factors Induced by Growth-Signaling.
In Brugge, J., Curran, T., Harlow, E.D. and McCormick, F.(eds.), Origins
of Human Cancer: A Comprehensive Review. Cold Spring Harbor Laboratory
Press, New Yorkpp. pp.353-pp.364.
Worley,
P.F., Cole, A.J., Murphy, T.H., Christy, B.A., Nakabeppu, Y. and Baraban,
J.M. (1990) Synaptic regulation of immediate-early genes in brain.
Cold Spring Harb. Symp. Quant. Biol., 55, 213-223.
Nakabeppu,
Y. and Nathans, D. (1989) The basic region of Fos mediates specific
DNA binding. EMBO J., 8, 3833-3841.
Kodama,
K.I., Nakabeppu, Y. and Sekiguchi, M. (1989) Cloning and expression
of the Bacillus subtilis methyltransferase gene in Escherichia coli ada-
cells. Mutat. Res., 218, 153-163.
Christy,
R.J., Yang, V.W., Ntambi, J.M., Geiman, D.E., Landschulz, W.H., Friedman,
A.D., Nakabeppu, Y., Kelly, T.J. and Lane, M.D. (1989) Differentiation-induced
gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein
interacts with and activates the promoters of two adipocyte-specific genes.
Genes Dev., 3, 1323-1335.
Yamagata,
Y., Odawara, K., Tomita, K., Nakabeppu, Y. and Sekiguchi, M. (1988)
Crystallization and preliminary X-ray diffraction studies of 3-methyladenine-DNA
glycosylase II from Escherichia coli. J. Mol. Biol., 204, 1055-1056.
Yoshikai,
T., Nakabeppu, Y. and Sekiguchi, M. (1988) Proteolytic cleavage of
Ada protein that carries methyltransferase and transcriptional regulator
activities. J. Biol. Chem., 263, 19174-19180.
Nakabeppu, Y., Ryder, K. and Nathans, D. (1988) DNA binding activities
of three murine Jun proteins: stimulation by Fos. Cell, 55, 907-915.
Takahashi,
K., Kawazoe, Y., Sakumi, K., Nakabeppu, Y. and Sekiguchi, M. (1988)
Activation of Ada protein as a transcriptional regulator by direct alkylation
with methylating agents. J. Biol. Chem., 263, 13490-13492.
Nakamura,
T., Tokumoto, Y., Sakumi, K., Koike, G., Nakabeppu, Y. and Sekiguchi,
M. (1988) Expression of the ada gene of Escherichia coli in response
to alkylating agents. Identification of transcriptional regulatory elements.
J. Mol. Biol., 202, 483-494.
Mizunoe,
Y., Nakabeppu, Y., Sekiguchi, M., Kawabata, S., Moriya, T. and Amako,
K. (1988) Cloning and sequence of the gene encoding the major structural
component of mannose-resistant fimbriae of Serratia marcescens. J. Bacteriol.,
170, 3567-3574.
Takano,
K., Nakabeppu, Y. and Sekiguchi, M. (1988) Functional sites of the
Ada regulatory protein of Escherichia coli. Analysis by amino acid substitutions.
J. Mol. Biol., 201, 261-271.
Lindahl,
T., Sedgwick, B., Sekiguchi, M. and Nakabeppu, Y. (1988) Regulation
and expression of the adaptive response to alkylating agents. Annu Rev
Biochem, 57, 133-157.
Ishizaki,
K., Tsujimura, T., Fujio, C., Zhang, Y.P., Yawata, H., Nakabeppu, Y.,
Sekiguchi, M. and Ikenaga, M. (1987) Expression of the truncated E.
coli O6-methylguanine methyltransferase gene in repair-deficient human
cells and restoration of cellular resistance to alkylating agents. Mutat.
Res., 184, 121-128.
Kondo,
H., Nakabeppu, Y., Kataoka, H., Kuhara, S., Kawabata, S. and Sekiguchi,
M. (1986) Structure and expression of the alkB gene of Escherichia
coli related to the repair of alkylated DNA. J. Biol. Chem., 261, 15772-15777.
Sakumi,
K., Nakabeppu, Y., Yamamoto, Y., Kawabata, S., Iwanaga, S. and Sekiguchi,
M. (1986) Purification and structure of 3-methyladenine-DNA glycosylase
I of Escherichia coli. J. Biol. Chem., 261, 15761-15766.
Takano,
K., Nakabeppu, Y., Maki, H., Horiuchi, T. and Sekiguchi, M. (1986)
Structure and function of dnaQ and mutD mutators of Escherichia coli.
Mol. Gen. Genet., 205, 9-13.
Ishizaki,
K., Tsujimura, T., Yawata, H., Fujio, C., Nakabeppu, Y., Sekiguchi, M.
and Ikenaga, M. (1986) Transfer of the E. coli O6-methylguanine methyltransferase
gene into repair-deficient human cells and restoration of cellular resistance
to N-methyl-N'-nitro-N-nitrosoguanidine. Mutat. Res., 166, 135-141.
Nakabeppu,
Y. and Sekiguchi, M. (1986) Regulatory mechanisms for induction of
synthesis of repair enzymes in response to alkylating agents: ada protein
acts as a transcriptional regulator. Proc. Natl. Acad. Sci. U. S. A.,
83, 6297-6301.
Sekiguchi,
M., Kondo, H., Sakumi, K. and Nakabeppu, Y. (1986) Molecular mechanism
of adaptive response to alkylating agents. In Shankel, D.M., Hartman,
P.E., Kada, T. and Hallaender, A.(eds.), Antimutagenesis and Anticarcinogenesis.
Plenum Publishing Co, New Yorkpp. pp.219-pp.229.
Sekiguchi, M. and Nakabeppu, Y. (1986) Adaptive response: Induced synthesis
of DNA repair enzymes by alkylating agents. Trends in Genet, 3, 51-54.
Nakabeppu,
Y., Mine, Y. and Sekiguchi, M. (1985) Regulation of expression of
the cloned ada gene in Escherichia coli. Mutat. Res., 146, 155-167.
Otsuka,
M., Nakabeppu, Y. and Sekiguchi, M. (1985) Ability of various alkylating
agents to induce adaptive and SOS responses: a study with lacZ fusion.
Mutat. Res., 146, 149-154.
Nakabeppu,
Y., Kondo, H., Kawabata, S., Iwanaga, S. and Sekiguchi, M. (1985)
Purification and structure of the intact Ada regulatory protein of Escherichia
coli K12, O6-methylguanine-DNA methyltransferase. J. Biol. Chem., 260,
7281-7288.
Nakabeppu,
Y., Kondo, H. and Sekiguchi, M. (1984) Cloning and characterization
of the alkA gene of Escherichia coli that encodes 3-methyladenine DNA
glycosylase II. J. Biol. Chem., 259, 13723-13729.
Nakabeppu,
Y., Miyata, T., Kondo, H., Iwanaga, S. and Sekiguchi, M. (1984) Structure
and expression of the alkA gene of Escherichia coli involved in adaptive
response to alkylating agents. J. Biol. Chem., 259, 13730-13736.
Yamamoto, Y., Kataoka, H., Nakabeppu, Y., Tsuzuki, T. and Sekiguchi,
M. (1983) The genes involved in the repair of alkylated DNA in Escherichia
coli K-12. In Friedberg, E.C. and Bridges, B.R.(eds.), Cellular Responses
to DNA Damage. Alan R. Liss, Inc., New Yorkpp. pp.271-pp.278.
Nakatsu,
Y., Nakabeppu, Y. and Sekiguchi, M. (1982) Action of T4 endonuclease
V on polydeoxyribonucleotides with apyrimidinic or apurinic sites. J.
Biochem., 91, 2057-2065.
Nakabeppu,
Y., Yamashita, K. and Sekiguchi, M. (1982) Purification and characterization
of normal and mutant forms of T4 endonuclease V. J. Biol. Chem., 257,
2556-2562.
Nakabeppu,
Y. and Sekiguchi, M. (1981) Physical association of pyrimidine dimer
DNA glycosylase and apurinic/apyrimidinic DNA endonuclease essential for
repair of ultraviolet-damaged DNA. Proc. Natl. Acad. Sci. U. S. A., 78,
2742-2746.
|