第802回 生医研セミナー(多階層生体防御システム研究拠点)

下記の通り、Ueli Grossniklaus先生によるセミナーを開催します。皆様のご来聴を心より歓迎致します。

※セミナーは英語で行われます。(Seminar in English)

演題 / Title

Convergent evolution of genomic imprinting in plants and mammals

演者 / Speaker

Prof. Ueli Grossniklaus
Department of Plant & Microbial Biology, University of Zurich, Switzerland

日時 / Date

2019年12月9日(月) Dec. 9 (Mon), 2019
16:00〜16:40

場所 / Venue

病院キャンパス 総合研究棟 1階 講義室102
以下の地図の33番です。
(http://www.kyushu-u.ac.jp/f/35767/2019hospital_2.pdf)

Lecture Room 102, 1F, Biomedical Research Station, Hospital Campus
No.33 on the following linked map.
(http://www.kyushu-u.ac.jp/f/35768/2019hospital-en_2.pdf)

要 旨 / Abstract

Research in our laboratory centers on the developmental genetics of plant reproduction. The characterization of mutants has revealed an extensive epigenetic regulatory network mediating maternal control over seed development. MEDEA (MEA) is involved in the epigenetic control of gene expression at two levels: First, the MEA gene is regulated by genomic imprinting, i.e. only the maternally inherited allele is transcribed after fertilization. Second, MEA encodes a plant homolog of Drosophila histone-methyl-transferase Enhancer of zeste [E(z)]. MEA is a subunit of one of the plant versions of animal Polycomb Repressive Complex 2 (PRC2), which controls cell proliferation and imprinted gene expression, suggesting that PRC2 complexes have been recruited to regulate similar processes in animals and plants. In order to get a better understanding of epigenetic regulation in plants, we are genetically dissecting the function and regulation of MEA. I will report on our efforts to identify cis-regulatory regions and trans-acting factors involved in the regulation of genomic imprinting at the MEA locus and show that a complex regulatory cascade involving diverse epigenetic mechanisms controls early development.

参考論文 / References

  1. Pires ND, Grossniklaus U.
    Different yet similar: evolution of imprinting in flowering plants and mammals.
    F1000Prime Rep. 2014 Aug 1;6:63.

連絡先 / Contact

生体防御医学研究所 エピゲノム制御学分野
佐々木 裕之 ・ 鵜木 元香
092 (642) 6761

Division of Epigenomics and Development, Medical Institute of Bioregulation
Hiroyuki SASAKI, Motoko UNOKI
TEL: 092 (642) 6761