The 781st MIB Seminar
(Joint Usage/Research Center for the Multi-stratified Host Defense System)
[Seminar in English]
Title
Democratizing Health Innovation
Speaker
Dr. Martin Burke
Associate Dean of Research,
Carle Illinois College of Medicine
Date
Nov. 13 (Tue), 2018
10：30～12：00
Venue
Seminar Room, 1F, Main Building, Medical Institute of Bioregulation, Hospital Campus
No.31 on the following linked map.
（http://www.kyushu-u.ac.jp/f/33952/2018hospital_2-en.pdf）
Abstract
We all care about being healthy. Yet only a small fraction of the 7.7 billion potential health innovators throughout the world currently have the opportunity to transform new ideas for improving healthcare into testable prototypes. The new Carle Illinois College of Medicine aims to harness this tremendous untapped human potential by democratizing health innovation and thereby empowering individuals and communities around the globe to help address some of the most important challenges facing society today. This talk will focus on some early momentum in this direction and opportunities for strategic partnership with Kyushu University through the development of a first-of-its-kind Medical Maker Lab (https://medicine.illinois.edu/research/medicalmakerlab/) a Global Community Immersion Program (https://medicine.illinois.edu/research/global-community-immersion-program/), and the new field of Progenerative Medicine (https://medicine.illinois.edu/focus-areas/). Progenerative Medicine targets diagnostics and therapeutics that autonomously perform higher-order functions to understand, promote and/or enhance human physiology. These include molecular prosthetics, nextgen imaging agents, biobots. It achieves these goals via forward design and automated synthesis of frontier molecules, cells, tissues, and systems that productively interface with people to promote health. This approach has particularly strong potential to promote healthy and meaningful aging, an important and growing challenge faced by all societies around the world.
Biography of Dr. Martine Burke
Dr. Burke completed his undergraduate degree in Chemistry at Johns Hopkins University in 1998, a PhD in organic synthesis at Harvard University in 2003, and an MD at Harvard Medical School in 2005. That same year Dr. Burke began his independent career in the Department of Chemistry at the University of Illinois at Urbana-Champaign where he is now a Full Professor and Associate Dean of Research for the new Carle-Illinois College of Medicine.
Dr. Burke’s research group focuses on the synthesis and study of small molecules that perform protein-like functions. Such molecules may ultimately serve as substitutes for missing or dysfunctional proteins that underlie human diseases, thereby operating as prostheses on the molecular scale. To enable these studies, Dr. Burke's group is pioneering a Lego-like synthesis platform that aims to make the process of complex small molecule construction as simple, efficient, and accessible as possible. This work has led to the development of hundreds of commercially-available MIDA boronate building blocks that are now enabling the more effective synthesis of small molecules in many different academic and industrial institutions throughout the world, and a machine that brings the power of this approach to non-specialists. Dr. Burke's group is now harnessing this chemistry to develop small molecules that replace missing proteins that underlie a wide range of human disease, including anemias, cystic fibrosis, enzyme deficiencies, and hemoglobinopathies.
Collectively, these efforts seek to harness the potential of molecular prosthetics to advance human health and bring the power of small molecule synthesis to everyone. Dr. Burke is the recipient of a number of honors and awards, including the Hirata Memorial Gold Medal from Japan, the Thieme IUPAC Prize in Synthetic Organic Chemistry, the Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis, and the Nobel Laureate Signature Award for Graduate Education in Chemistry. Dr. Martine also holds many patents and has (co-)founded six biotechnology companies, including REVOLUTION Medicines and Ambys Medicines.
Contact
Medical Institute of Bioregulation
Yusaku Nakabeppu
TEL: 092(642)6800