The 758th MIB Seminar
(Joint Usage/Research Center for the Multi-stratified Host Defense System)
[Seminar in English]
Title
The cellular and molecular basis for T cell development
Speaker
Takeshi Nitta, Ph.D.
Associate Professor
Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
Date
Jan. 25 (Thu), 2018
16:00~17:00
Venue
Seminar Room, Main Building 1F, Medical Institute of Bioregulation
No.26 on the following linked map.
(http://www.kyushu-u.ac.jp/f/30074/Hospital_en-2017.pdf)
Abstract
Understanding T cell development is one of major goals of the immunology. We have been studying on cellular and molecular mechanisms for how functionally optimized T cells are generated in the thymus. Our recent results from different perspectives and approaches – T cell receptor signaling, thymic stromal cell function, and human genetic variation – will be presented and discussed.
Publications
- Muro R, et al. γδTCR recruits the Syk-PI3K axis to drive proinflammatory differentiation program. J Clin Invest, in press.
- Nitta T, et al. Human thymoproteasome variations influence CD8 T cell selection. Sci Immunol, 2, eaan5165, 2017.
- Nitta T, et al. The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells. EMBO Rep, 16, 638-653, 2015.
Contact
Medical Institute of Bioregulation
Yusaku Nakabeppu
Tel:092-642-6800