第757回 生医研セミナー(多階層生体防御システム研究拠点)


下記の通り、宮崎 正輝 先生によるセミナーを開催致します。皆様方のご参加を心よりお待ちしております。

※セミナーは英語で行われます。(Seminar in English)

演題 / Title

Lymphocyte Development and Transcriptional Regulation

演者 / Speaker

宮崎 正輝 先生
京都大学ウィルス・再生医科学研究所再生免疫学分野 准教授

Masaki Miyazaki, M.D., Ph.D.
Associate Professor
Department of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University

日時 / Date

2018年1月25日(木)  Jan. 25 (Thu), 2018
14:00~15:00

場所 / Venue

病院キャンパス 生体防御医学研究所 本館1階 会議室
以下の地図の26番です。
(http://www.kyushu-u.ac.jp/f/30078/Hospital_jp-2017.pdf)

Seminar Room, Main Building 1F, Medical Institute of Bioregulation
No.26 on the following linked map.
(http://www.kyushu-u.ac.jp/f/30074/Hospital_en-2017.pdf)

要 旨 / Abstract

Immune system is composed of innate and adaptive immune cells. Two distinct type of lymphocytes have been identified, adaptive and innate lymphoid cells. It is well-known that bHLH transcription factor E-proteins including E2A, HEB and E2-2, and Id-proteins (Id1-4) orchestrate the entire lymphoid cell differentiation, such as T and B cell, DC, and Innate Lymphoid Cells (ILCs). As well as B cell, E2A and HEB act in synergy to establish T cell identity and to suppress the aberrant development of ILCs in the thymus, through the regulation of T cell-specific enhancer repertoire. In addition, I would like to discuss about the role of E-Id protein axis during T cell development and activation.

業績 / Publication

Miyazaki M, et al. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity 46, 818-834 (2017)

連絡先 / Contact

生体防御医学研究所
中別府 雄作 092(642)6800

Medical Institute of Bioregulation, Yusaku Nakabeppu
Tel:092-642-6800