Common Research Facilities
Contact
Medical Institute of Bioregulation, Kyushu University
3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JAPAN
TEL +81-92-642-6814
FAX +81-92-642-6246

The 757th MIB Seminar
(Joint Usage/Research Center for the Multi-stratified Host Defense System)

[Seminar in English]

Title

Lymphocyte Development and Transcriptional Regulation

Speaker

Masaki Miyazaki, M.D., Ph.D.
Associate Professor
Department of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University

Date

Jan. 25 (Thu), 2018
14:00~15:00

Venue

Seminar Room, Main Building 1F, Medical Institute of Bioregulation
No.26 on the following linked map.
(http://www.kyushu-u.ac.jp/f/30074/Hospital_en-2017.pdf)

Abstract

Immune system is composed of innate and adaptive immune cells. Two distinct type of lymphocytes have been identified, adaptive and innate lymphoid cells. It is well-known that bHLH transcription factor E-proteins including E2A, HEB and E2-2, and Id-proteins (Id1-4) orchestrate the entire lymphoid cell differentiation, such as T and B cell, DC, and Innate Lymphoid Cells (ILCs). As well as B cell, E2A and HEB act in synergy to establish T cell identity and to suppress the aberrant development of ILCs in the thymus, through the regulation of T cell-specific enhancer repertoire. In addition, I would like to discuss about the role of E-Id protein axis during T cell development and activation.

Publications

  1. Miyazaki M, et al. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity 46, 818-834 (2017)

Contact

Medical Institute of Bioregulation
Yusaku Nakabeppu
Tel:092-642-6800