The 757th MIB Seminar
(Joint Usage/Research Center for the Multi-stratified Host Defense System)
[Seminar in English]
Title
Lymphocyte Development and Transcriptional Regulation
Speaker
Masaki Miyazaki, M.D., Ph.D.
Associate Professor
Department of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
Date
Jan. 25 (Thu), 2018
14:00~15:00
Venue
Seminar Room, Main Building 1F, Medical Institute of Bioregulation
No.26 on the following linked map.
(http://www.kyushu-u.ac.jp/f/30074/Hospital_en-2017.pdf)
Abstract
Immune system is composed of innate and adaptive immune cells. Two distinct type of lymphocytes have been identified, adaptive and innate lymphoid cells. It is well-known that bHLH transcription factor E-proteins including E2A, HEB and E2-2, and Id-proteins (Id1-4) orchestrate the entire lymphoid cell differentiation, such as T and B cell, DC, and Innate Lymphoid Cells (ILCs). As well as B cell, E2A and HEB act in synergy to establish T cell identity and to suppress the aberrant development of ILCs in the thymus, through the regulation of T cell-specific enhancer repertoire. In addition, I would like to discuss about the role of E-Id protein axis during T cell development and activation.
Publications
- Miyazaki M, et al. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity 46, 818-834 (2017)
Contact
Medical Institute of Bioregulation
Yusaku Nakabeppu
Tel:092-642-6800