第685回 生医研セミナー(多階層生体防御システム研究拠点)
免疫機構研究セミナー
下記の通り、Dr. Bernard Malissenによるセミナーを開催致します。皆様のご来聴を心より歓迎いたします。
演題
Toward an integrative biology of T cells and dendritic cells. （seminar in English）
演者
Dr. Bernard Malissen
Centre d’Immunologie de Marseille-Luminy, INSERM, CNRS,
Aix-Marseille Université, Marseille, France
日時
2014年 11月28日（金） Nov. 28 (Fri), 2014
17：00～18：30
場所
九州大学 病院キャンパス内 生体防御医学研究所 本館1階 会議室
以下の地図の21番の建物になります。
（http://www.kyushu-u.ac.jp/access/map/hospital/hospital.html）
Seminar Room, Main Building 1F, Medical Institute of Bioregulation
No.21 on the following linked map.
（http://www.kyushu-u.ac.jp/access/map/hospital/hospital-e.html）
要旨
T cells probe the surface of dendritic cells in search of molecular cues reflecting the antigenic and inflammatory status of the body tissues and its malfunction has pathological consequences. To make sense of the formidable complexity of the signal transduction networks involved in T cell activation, we have combined high-throughput “omic”approaches that simultaneously measure large numbers of parameters and genetic screens designed to identify novel components of the CD28 costimulatory pathway.
Using gene-targeted mice bearing a genetic tag permitting affinity purification coupled with mass-spectrometry analysis, signalosomes were directly isolated from primary CD4+ T cells. On that basis, we showed that among the 90 proteins that composed the proximal T cell antigen eceptor signaling network, 65 proteins have not been identified before.
In addition, analysis of the CD28 co-stimulatory pathway led us to the identification of a novel essential component. Therefore, rather than the tens of components previously thought to compose the TCR and the CD28 signal transduction networks, our studies suggest the involvement of hundreds. In view of the grand challenges that exist, humility is a more appropriate reaction than hubris.
However, as we will illustrate the prospects of integrating in vitro, in vivo and in silico approaches, each bearing unique advantages and drawbacks, to understand T cell activation are excellent.
Key words: T cells, dendritic cells, functional genomics
連絡先
生体防御医学研究所 分子免疫学分野 山崎 晶
電話：092-642-4614