第666回 生医研セミナー(多階層生体防御システム拠点)
ゲノミクスエピゲノミクス研究拠点セミナー
下記の通り、九州大学大学院医学研究院の安川武宏先生によるセミナーを開催致します。
皆様のご来聴を心より歓迎いたします。
演題
The mitochondrial genome: a brief overview of the property and clinical relevance and the latest updates of the replication mechanism
（Seminar in English）
演者
安川 武宏 先生 Dr. Takehiro Yasukawa
九州大学大学院 医学研究院臨床検査医学
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University
日時
2014年 1月 24日（金） Jan. 24 (Fri), 2014
15：00～16：00
場所
九州大学 病院キャンパス内 生体防御医学研究所 本館1階 会議室
以下の地図の21番の建物になります。
（http://www.kyushu-u.ac.jp/access/map/hospital/hospital.html）
要旨
Faithful copying and maintenance of mitochondrial DNA (mtDNA) are fundamental to the oxidative phosphorylation and therefore to life. The importance of mtDNA maintenance can be recognised by the fact that defects in mtDNA are a common cause of human genetic disease. Also, possible links of ageing and mtDNA abnormality are implicated. For three decades a simple replication model for mammalian mtDNA had generally been accepted. A series of recent studies, however, seriously challenged the model and demonstrated that mitochondria employ complex DNA replication system with more than one replication mechanism, none of which is identical to the old model. The most striking feature of mtDNA replication is that significant proportion of the replication intermediates contain long stretch of RNA, which is unprecedented in DNA replication.
In the seminar I will briefly overview the property and the clinical relevance of human mtDNA and present our recent understanding of mtDNA replication.
＜参考文献＞
- Reyes A., Kazak L., Wood S.R., Yasukawa T., Jacobs H.T., Holt I.J.
Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts.
Nucleic Acids Res. 41, 5837-5850 (2013) - Yasukawa et al.
Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.
EMBO J. 25, 5358-5371 (2006) - Yasukawa et al.
A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.
Mol. Cell 18, 651-662 (2005)
連絡先
九州大学 生体防御医学研究所 エピゲノム制御学分野 一柳 健司
Division of Epigenomics and Development, MIB, Kenji ICHIYANAGI
電話：092-642-6760