第622回 生医研セミナー(多階層生体防御システム研究拠点)
免疫機構研究セミナー


下記のとおり、清野宏先生によるセミナーを開催致します。
清野宏先生は長年にわたり腸管免疫研究の世界的リーダーとしてご活躍されています。
最近のご研究では、P2X7 プリン受容体発現粘膜マスト細胞が細胞外ATPを介して腸管炎症の誘導と調節に重要な役割を演じていることを明らかにされました。粘膜自然免疫細胞、上皮細胞および腸管常在菌3者間バランス均衡の状態とその不均衡がもたらす炎症性疾患について最新の情報をご提供頂きます。皆様の積極的なご参加をお待ちしております。

演題 Mucosal Integrated Trialogue Regulation System for Mutualism, Inflammation and Elimination

演者清野 宏 先生
東京大学医科学研究所 感染・免疫部門 炎症免疫学分野教授
東京大学医科学研究所長

日時平成24年5月8日(火)18時より19時まで

場所馬出医学系キャンパス内 総合研究棟 セミナー室 105
以下の地図の1番の建物になります。
http://www.kyushu-u.ac.jp/access/map/hospital/hospital.html

要旨  The digestive tract is covered by a single layer of mucosal epithelial cells which continuously exposed to infinite antigenic challenges in handling its day-to-day duties. The intestinal tract is thus equipped with the mucosal immune system (MIS) offering the first line of surveillance and defense forces against invasion of pathogens. At same time, the MIS also expose to an enormous number and volume of innocuous and/or instructive antigens which need to be appropriately ‘ignored’. Mounting an immunologically harmonized response therefore represents a key decision-making process of active and/or quiescent immune responses by the MIS. To this end, the MIS has been shown to be enriched with the variety of innate and acquired immunity associated cells. Our previous studies have provided new evidence for the intra-tissue habitation of commensal flora in the organized lymphoid structure associated with gut mucosa (e.g.,Peyer’s pathch). Intestinal epithelial cells possess unique α(1,2)- fucose- moiety and these cells are thus refereed as fucosylated ECs (F-ECs) which are contributing in the formation of co-habitation platform for commensal bacteria. F-ECs were predominantly observed in the ileum that is induced and maintained by commensal bacteria. Furthermore, these epithelial fucoses are induced and regulated by mucosal innate immunity cells. Our most recent study has demonstrated that mucosal mast cells expressing P2X7 purinoceptors play critical role in the induction and regulation of intestinal inflammation via extracellular ATP. Thus, our data provide the new perspective on the triangular link among mucosal innate immunity cells, epithelial cells and intestinal microbiota for the gut mutualisum and the disruption of the trialogue system may lead to the development of pathological condition including inflammation.

連絡先生体防御医学研究所 ゲノム病態学分野
谷 憲三朗
電話:092-642-6434


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