第 616 回生医研セミナー(多階層生体防御システム研究拠点)
ゲノミクスエピゲノミクス研究拠点セミナー

この度、京都大学の斎藤通紀先生に生体防御医学研究所でのセミナーをお願い致しました。このセミナーでは、マウスの多能性幹細胞から正常な産仔を得ることができる生殖細胞を誘導する技術についてお話しいただきます。講演は英語で行われます。ご来聴を歓迎致します。

演題Mechanism and reconstitution in vitro of germ cell specification in mice.
(seminar in English)

演者斎藤 通紀 先生  Prof. Mitinori Saitou
京都大学大学院医学研究科 機能微細形態学 教授
Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University

日時平成24年4月13日(金)  Apr.13, (Fri) 2012
17:00〜18:00

場所馬出医学系キャンパス内 総合研究棟 セミナー室 105
以下の地図の1番の建物になります。
http://www.kyushu-u.ac.jp/access/map/hospital/hospital.html

Biomedical Research Station 1F, Seminar Room 105
No.1 on the following linked map
http://www.kyushu-u.ac.jp/access/map/hospital/hospital-e.html

要旨 The germ cell lineage ensures the creation of new individuals, thereby perpetuating and diversifying the genetic and epigenetic information across the generations. We have been investigating signaling, global transcription and epigenetic dynamics associated with the specification of the germ cell lineage in mice, and have proposed a concept that germ cell specification involves an integration of three key events: repression of the somatic program, re-acquisition of potential pluripotency, and an ensuing genome-wide epigenetic reprogramming. Recently, using pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells), we have succeeded in precisely reconstituting the mouse germ-cell specification pathway in culture. This work will serve as a foundation for the better elucidation of early germ-cell biology, including the mechanism of action of key transcriptional regulators and of genome-wide epigenetic reprogramming, as well as for the reconstitution of the entire germ-cell development both in males and females in vitro, not only in mice but also in other mammals, including humans.

業績
  1. Hayashi, K. et al. Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. Cell 146, 519-32 (2011)

連絡先生体防御医学研究所 エピゲノム学分野 佐々木 裕之
Division of Epigenomics, MIB, Hiroyuki SASAKI
電話:092-642-6759


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