この度、国立がん研究センター研究所エピゲノム解析分野の牛島俊和先生に生体防御医学研究所でのセミナーをお願い致しました。
本セミナーでは、ピロリ菌感染や喫煙による局所的なエピゲノム変化と、それを生かしたがんの診断や予防の可能性についてお話しいただきます。講演は英語で行われます。ご来聴を歓迎致します。
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| 演題 | Epigenomic Record of Our Life and Cancer Risk
（seminar in English）
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| 演者 | 牛島 俊和 先生
国立がん研究センター研究所エピゲノム解析分野 分野長
Dr. Toshikazu Ushijima
Division of Epigenomics, National Cancer Center Research Institute
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| 日時 | 平成２３年１０月２１日（金）１７時より１８時まで
Oct. 21, 2011(Fri), 17:00-18:00
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| 場所 | 馬出医学系キャンパス内 生体防御医学研究所 本館１階 会議室
以下の地図の21番になります。
（http://www.kyushu-u.ac.jp/access/map/hospital/hospital.html）
Medical Institute of Bioregulation, Main Building 1F, Seminar Room
No.21 on the following linked map
（http://www.kyushu-u.ac.jp/access/map/hospital/hospital-e.html）
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| 要旨 |
Exposure to environmental factors, such as Helicobacter pylori infection and smoking, leads to cancer development. We have demonstrated that such exposures induce epigenomic alterations in normal-appearing tissues, and that their accumulation levels correlate with cancer risk. Specific types of inflammation are critical for induction of aberrant DNA methylation, and specific genes are methylated in response to specific environmental factors. Clarification of the induction mechanisms is expected to lead to novel strategies of cancer prevention, and measurement of the accumulated epigenomic alterations can be used as a risk marker that reflects our life.
- Katsurano, M. et al. Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction. Oncogene (in press).
- Niwa, T. et al. Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res. 70: 1430-1440, 2010.
- Takeshima, H. et al. The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res. 19: 1974-1982, 2009.
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| 連絡先 | 生体防御医学研究所 エピゲノム学分野 佐々木 裕之
Division of Epigenomics, MIB, Hiroyuki SASAKI
電話：092-642-6759 |
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