この度、名古屋大学大学院医学系研究科・病理病態学講座・生体反応病理学/分子病理診断学の豊國伸哉博士に生体防御医学研究所でのセミナーをお願いしました。
セミナーでは、鉄毒性病としてのがん：アスベスト誘発中皮腫発がん機構についてご講演いただきます。講演は英語で行われます。皆様是非ご来聴下さい。
The speaker will give his lecture in English. Please join us on this occasion.
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| 日時 | 平成２３年２月１８日（金）１６時〜１８時 |
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| 場所 | 馬出医学系キャンパス内 生体防御医学研究所 本館１階 会議室
Medical Institute of Bioregulation, Main Building 1F, Seminar Room
以下の地図の20番になります。
（http://www.kyushu-u.ac.jp/access/map/hospital/hospital.html）
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| 演題 | Cancer as a ferrotoxic disease: asbestos-induced mesothelial carcinogenesis
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| 演者 | 豊國 伸哉 先生
名古屋大学大学院医学系研究科 病理病態学講座
生体反応病理学/分子病理診断学 教授
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| 要旨 |
Iron is abundant universally. During the evolutionary processes, humans have selected iron as a carrier of oxygen inside the body. However, iron works as a double-edged sword, and its excess is a risk for cancer, presumably via generation of reactive oxygen species. Thus far, pathologic conditions such as hemochromatosis, chronic viral hepatitis B and C, exposure to asbestos fibers as well as endometriosis have been recognized as iron overload-associated risks for human cancer. Indeed, iron is carcinogenic in animal experiments. These reports unexpectedly revealed that there are target genes in iron-induced carcinogenesis and that iron-catalyzed oxidative DNA damage is not random in vivo. It is becoming clear that asbestos-induced mesothlial carcinogenesis is iron-catalyzed oxidative stress-dependent because target genes (CDKN2A/2B) are common in three different rat models. Furthermore, a recent epidemiological study reported that iron reduction by phlebotomy decreased cancer risk in the apparently normal population. These results warrant reconsideration of the role of iron in carcinogenesis and suggest that fine control of body iron stores would be a wise strategy for cancer prevention. I hope that these novel findings connect cancer study to systems biology.
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| 連絡先 | 生体防御医学研究所 脳機能制御学分野
中別府 雄作
電話：092-642-6800 |
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