Publications

Authors' names are linked to the abstract pages on PubMed, etc.
Last update: Jan 10, 2017
Sano T., Kawata K., Ohno S., Yugi K., Kakuda H., Kubota H., Uda S., Fujii M., Kunida K., Hoshino D., Hatano A., Ito Y., Sato M., Suzuki Y., and Kuroda S.
Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin.
Sci. Signal., 9(455): ra112, 2016.

Yugi K., Kubota H., Hatano A., and Kuroda S.
Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers.
Trends Biotechnol., 34(4): 276-90, 2016.

Fukuda S., Nishida-Fukuda H., Nanba D., Nakashiro K., Nakayama H., Kubota H., and Higashiyama S.
Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.
Sci. Rep., 6: 20209, 2016.
Katsura Y., Kubota H., Kunida K., Kuroda S., and Ozawa T.
An optogenetic system for interrogating the temporal dynamics of Akt.
Sci. Rep., 5: 14589, 2015.

Ohashi K., Komada H., Uda S., Kubota H., Iwaki T., Fukuzawa H., Komori Y., Fujii M., Toyoshima Y., Sakaguchi K., Ogawa W., and Kuroda S.
Glucose Homeostatic Law: Insulin Clearance Predicts the Progression of Glucose Intolerance in Humans.
PLoS ONE, 10(12): e0143880, 2015.
Noguchi R., Kubota H., Yugi K., Toyoshima Y., Komori Y., Soga T., and Kuroda S.
The Selective Control of Glycolysis, Gluconeogenesis and Glycogenesis by Temporal Insulin Patterns.
Mol. Syst. Biol., 9: 664, 2013.

Uda S., Saito T., Kudo T., Kokaji T., Tsuchiya T., Kubota, H., Komori Y., Ozaki Y., and Kuroda, S.
Robustness and compensation of information transmission of signaling pathways.
Science, 34(6145): 558-61, 2013.

Akimoto Y., Yugi K., Uda S., Komori Y., Kubota H., and Kuroda S.
The extraction of simple relationships in growth factor-specific multiple-input and multipleoutput systems in cell-fate decisions by backward elimination PLS regression.
PLoS ONE, 8(9): e72780, 2013.

Kubota H., and Kuroda S.
Temporal Coding of Signaling Pathway.
生物物理, 53(4): 184-189, 2013.
Kubota H., Noguchi R., Toyoshima Y., Ozaki Y., Uda S., Watanabe K., Ogawa W., and Kuroda S.
Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway.
Mol. Cell, 46: 820-32, 2012.
Fujita K., Toyoshima Y., Uda S., Ozaki Y., Kubota H., and Kuroda S.
Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics.
Sci. Signal., 3 (132): ra56, 2010.

Ozaki Y., Uda S., Saito T., Chung J., Kubota H., and Kuroda, S.
A quantitative image cytometry technique for time series or population analyses of signaling networks.
PLoS ONE, 5(4): e9955, 2010.

Chung J., Kubota H., Ozaki Y., Uda S., and Kuroda, S.
Timing-Dependent Actions of NGF Required for Cell Differentiation.
PLoS ONE, 5(2): e9011, 2010.

Matsuo R., Kubota H., Obata T., Kito K., Ota K., Kitazono T., Ibayashi S., Sasaki T., Iida M., and Ito T.
The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR inactivation.
FEBS Lett., 579: 2433-2438, 2005.

Ichimura T., Kubota H., Goma T., Mizushima N., Ohsumi Y., Iwago M., Kakiuchi K., Shekhar H. U., Shinkawa T., Taoka M, Ito T., and Isobe T.
Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast.
Biochemistry, 43: 6149-6158, 2004.

Kubota H., Obata T., Ota K., Sasaki T., and Ito T.
Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN2.
J. Biol. Chem., 278: 20457-20460, 2003.

Ito T., Ota K., Kubota H., Yamaguchi Y., Chiba T., Sakuraba K., and Yoshida M.
Roles for the two-hybrid system in exploration of the yeast protein interactome.
Mol. Cell. Proteomics, 1: 561-566, 2002.

Kubota H., Ota K., Sakaki Y., and Ito T.
Budding yeast GCN1 binds the GI domain to activate the eIF2α kinase GCN2.
J. Biol. Chem., 276: 217591-17596, 2001.

Kubota H., Sakaki Y., and Ito T.
GI domain-mediated association of the eukaryotic initiation factor 2α kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast.
J. Biol. Chem., 275: 20243-20246, 2000.

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Hiroyuki, K. and Kuroda, S.
Temporal Coding of Insulin Signaling
Protein modification in pathogenic dysregulation of signaling (Springer), 95-109, 2015.