九州大学病院
  • 先端分子・細胞治療科
  • 分子・細胞調製センター
九州大学 生体防御医学研究所
  • ゲノム病態学分野
  • 悪性腫瘍に対する新規免疫・遺伝子治療薬開発研究部門(寄附研究部門)
LINK
  • 九州大学
  • 九州大学病院
  • 九州大学 先端医療イノベーションセンター
  • 九州大学生体防御医学研究所
九州大学 生体防御医学研究所 ゲノム病態学分野

業績


論文

原著論文 2014 年~2015年

  • Narusawa M, Inoue H, Sakamoto C, Matsumura Y, Takahashi A, Inoue T, Watanabe A, Miyamoto S, Miura Y, Hijikata Y, Tanaka Y, Inoue M, Takayama K, Okazaki T, Hasegawa M, Nakanishi Y, Tani K. TLR7 Ligand Augments GM-CSF-Initiated Antitumor Immunity through Activation of Plasmacytoid Dendritic Cells. Cancer Immunol Res 2:568-580, 2014 [PubMed]
  • Nii T, Marumoto T, Kawano H, Yamaguchi S, Liao J, Okada M, Sasaki E, Miura Y, Tani K. Analysis of essential pathways for self-renewal in common marmoset embryonic stem cells. FEBS Open Bio 4:213-9, 2014 [PubMed]
  • Yamaguchi S, Marumoto T, Nii T, Kawano H, Liao J, Nagai Y, Okada M, Takahashi A, Inoue H, Sasaki E, Fujii H, Okano S, Ebise H, Sato T, Suyama M, Okano H, Miura Y, Tani K. Characterization of common marmoset dysgerminoma-like tumor induced by the lentiviral expression of reprogramming factors. Cancer Sci 105(4):402-8, 2014 [PubMed]
  • Hamada, K., Shirakawa, T., Terao, S., Gotoh, A., Tani, K., Huang W. Biosafety studies of carrier cells infected with a replication-competent adenovirus introduced by IAI.3B promoter. Mol Ther Methods Clin Dev 1:14019, 2014
  • Kummalue T, Inoue T, Miura Y, Narusawa M, Inoue H, Komatsu N, Wanachiwanawin W, Sugiyama D, Tani K. Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells. Exp Hematol 43(5):414-423.e1, 2015 [PubMed]

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原著論文 2012 年~2013年

  • Miyamoto S, Inoue H, Nakamura T, Yamada M, Sakamoto C, Urata Y, Okazaki T, Marumoto T, Takahashi A, Takayama K, Nakanishi Y, Shimizu H, Tani K. Coxsackievirus B3 is an oncolytic virus with immunostimulatory properties that is active against lung adenocarcinoma. Cancer Res. 72(10):2609-2, 2012 [PubMed]
  • Yokota Y, Inoue H, Matsumura Y, Nabeta H, Narusawa M, Watanabe A, Sakamoto C, Hijikata Y, Iga-Murahashi M, Takayama K, Sasaki F, Nakanishi Y, Yokomizo T, Tani K. Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems. Blood 120(17):3444-5, 2012 [PubMed]
  • Somada S, Muta H, Nakamura K, Sun X, Honda K, Ihara E, Akiho H, Takayanagi R, Yoshikai Y, Podack ER, Tani K. CD30 Ligand/CD30 Interaction is involved in pathogenesis of inflammatory bowel disease. Dig Dis Sci. 57: 2031-2037, 2012 [PubMed]
  • Dong Y., Kobayashi S, Tian Y, Ozawa M, Hiramoto T, Izawa K, Bai Y, Soda Y, Sasaki E, Itoh T, Maru Y, Oyaizu N, Tojo A, Kai C, Tani K. Leukemogenic fusion gene (p190 BCR-ABL) transduction into hematopoietic stem/progenitor cells in the common marmoset. Open J Blood Dis. 2(1): 1-10 2012 [PDF]
  • Hamada K, Yoshihara C, Ito T, Tani K, Tagawa M, Sakuragawa N, Itoh H, Koyama Y. Antitumor effect of chondroitin sulfate-coated ternary granulocyte macrophage colony- stimulating factor plasmid complex for ovarian cancer. J Gene Med. 14:5120-127, 2012.
  • Mizuochi C, Fraser ST, Biasch K, Horio Y, Kikushige Y, Tani K, Akashi K, Tavian M, Sugiyama D. Intra-aortic clusters undergo endothelial to hematopoietic phenotypic changes in early embryogenesis. PLoS One 7(4):e35763, 2012
  • Nunomura S, Shimada S, Kametani Y, Yamada Y, Yoshioka M, Suemizu H, Ozawa M, Itoh T, Kono A, Suzuki R, Tani K, Ando K, Yagita H, Ra C, Habu S, Satake M, Sasaki E. Double expression of CD34 and CD117 on bone marrow progenitors is a hallmark of the development of functional mast cell of Callithrix jacchus (common marmoset). Int Immunol. 24(9):593-603, 2012
  • Hiramoto T, Ebihara Y, Mizoguchi Y, Nakamura K, Yamaguchi K, Ueno K, Nariai N, Mochizuki S, Yamamoto S, Nagasaki M, Furukawa Y, Tani K, Nakauchi H, Kobayashi M, Tsuji K. Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells. Proc Natl Acad Sci USA 110(8):3023-8, 2013 [PubMed]
  • Kobayashi S, Tian Y, Ohno N, Yuji K, Ishigaki T, Isobe M, Tsuda M, Oyaizu N, Watanabe E, Watanabe N, Tani K, Tojo A, Uchimaru K. The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I. PLoS One 8(1):e53728, 2013
  • Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamoto S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y, Tani K. Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells. Mol Ther 21(6):1242-50, 2013 [PubMed]
  • Kurita R, Suda N, Sudo K, Miharada K, Hiroyama T, Miyoshi H, Tani K, Nakamura Y. Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells. PLoS One 8(3):e59890, 2013
  • Chen MH, Soda Y, Izawa K, Kobayashi S, Tani K, Maruyama K, Tojo A, Asano S. A versatile drug delivery system using streptavidin-tagged pegylated liposomes and biotinylated biomaterials. Int J Pharm 454(1):478-8, 2013
  • Ye F, Zhang Y, Liu Y, Yamada K, Tso JL, Menjivar JC, Tian JY, Yong WH, Schaue D, Mischel PS, Cloughesy TF, Nelson SF, Liau LM, McBride W, Tso CL. Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence. PLoS One 8(11):e80397, 2013

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原著論文 2010年~2011年

  • Hamada K, Zhang T, Desaki J, Nakashiro K, Itoh H, Tani K, Koyama Y, Hamakawa H. Carrier cell-mediated cell lysis of squamous cell carcinoma cells by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus. J Gene Med. 12:545-554, 2010.
  • Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack ER, Yoshikai Y. CD30 Ligand/CD30 Plays a Critical Role in Th17 Differentiation in Mice. J Immunol. 185:2222-2230, 2010.
  • Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack ER, Iwakura Y, Yoshikai Y. CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses. J Immunol. 185:7671-80, 2010.
  • Inoue T, Sugiyama D, Kurita R, Oikawa T, Kulkeaw K, Kawano H, Miura Y, Okada M, Suehiro Y, Takahashi A, Marumoto T, Inoue H, Komatsu N, Tani K. APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cells in mice and humans. Stem Cell Rev. 7(1):43-52, 2011. [PubMed]
  • Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H. Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells. Oncol Rep. 25:795-802, 2011.
  • Tian Y, Kobayashi S, Ohno N, Isobe M, Tsuda M, Zaike Y, Watanabe N, Tani K, Tojo A, Uchimaru K. Leukemic T cells are specifically enriched in a unique CD3(dim) CD7(low) subpopulation of CD4(+) T cells in acute-type adult T-cell leukemia. Cancer Sci. 102: 569-577, 2011.
  • Inoue T, Kulkeaw K, Okayama S, Tani K, Sugiyama D. Variation in mesodermal and hematopoietic potential of adult skin-derived induced pluripotent stem cell lines in mice. Stem Cell Rev. 7:958-968, 2011.
  • Maeda,T., Kurita, R., Yokoo, T., Tani, K., Makino, N. Telomerase inhibition promotes an initial step of cell differentiation of primate embryonic stem cell. Biochem Biophys Res Commun. 407:491-494, 2011.
  • Takahashi A, Tokita H, Takahashi K, Takeoka T, Murayama K, Tomotsune D, Ohira M, Iwamatsu A, Ohara K, Yazaki K, Koda T, Nakagawara A, Tani K. A novel potent tumour promoter aberrantly overexpressed in most human cancers. Sci Rep. 1:15, 2011. [PubMed]

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原著論文 2008年~2009年

  • Inoue, H., Iga, M., Xin, M., Asahi, S., Nakamura,T., Kurita, R., Nakayama, M., Nakazaki, Y., Takayama, K. Nakanishi, Y., Tani, K. TARC and RANTES Enhance Antitumor Immunity Induced by the GM-CSF- Transduced Tumor Vaccine in a Mouse Tumor Model. Cancer Immunol Immun. 57: 1399-1411, 2008 [PubMed]
  • Kurita, R., Oikawa, T., Okada, M., Yokoo, T., Kurihara, Y., Honda, Y., Kageyama, R., Suehiro, Y., Okazaki, T., Iga, M., Miyoshi, H., Tani, K. Construction of a high performance human fetal liver- derived lentiviral cDNA library. Mol Cell Biochem 319: 181-187, 2008 . [PubMed]
  • Inoue, H., Iga, H., Nabeta, H., Yokoo, T., Suehiro, Y., Okano, S., Inoue, M.., Kinoh, H., Katagiri,H., Takayama, K., Yonemitsu, Y., Hasegawa, M., Nakamura, Y., Nakanishi, Y., Tani, K. Non-transmissible SeV encoding GM-CSF is a novel and potent vector system to produce autologous tumor vaccines. Cancer Science 99: 2315-2326, 2008 [PubMed]
  • Yanagie , H., , Tanabe, T., Sumimoto, H., Sugiyama, H., Matsuda, S., Nonaka, Y., Ogiwara, N., Sasaki, K., Tani, K,., Takamoto, S., Tkahashi, H., Eriguchi, M., Tumor growth suppression by adenovirus-mediated introduction of a cell growth suppressing gene tob in a pancreatic cancer model. Biomed Pharmacother 63:275-286, 2009
  • Tsuruta, T., Tani,K. Basophilic granulocytes. Cell Biol Res Horizons 2009 (in press)
  • Kummalue,T., Jiratchariyakul,W.,Srisapoomi, T., Sukpanichnant, S.,Hara,T., Kenzaburo T., Antiproliferative effect of Cucurbitacin B extracted from Trichosanthes cucumerina L. on human cancer cell lines. Siriraj Med J 61: 75-77, 2009. [PDF]
  • Kametani, Y., Suzuki, D., Kohu, K., Satakae, M.., Suemizu, H., Sasaki, E., Ito, T., Tamaoki, N., Mizushima, T., Ozawa, M., Tani, K., Kito, M., Arai, H., Koyanagi, A., Yagita, H., Habu, S. Development of monoclonal antibodies for analyzing immune and hematopoietic systems of common marmoset. Exp Hematol 2009 (in press)
  • Thacker EE, Nakayama M, Smith BF, Bird RC, Muminova Z, Strong TV, Timares L, Korokhov N, O'Neill AM, de Gruijl TD, Glasgow JN, Tani K,Curiel DT. A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific immune responses in vivo. Vaccine. 2009 Sep 26. [Epub ahead of print] PubMed PMID: 19786146.
  • Meng X, Nakamura T, Okazaki T, Inoue H, Takahashi A, Miyamoto S, Sakaguchi G, Eto M, Naito S, Takeda M, Yanagi Y, Tani K. Enhanced antitumor effects of an engineered measles virus Edmonston strain expressing the wild-type N, P, L genes on human renal cell carcinoma. Mol Ther 18(3):544-51, 2010. [PubMed]

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原著論文 2006~2007年

  • Kang X., Xinru Xiao, X., Harata M., Bai, Y., Nakazaki Y., Soda, Y., Kurita, R., Tanaka T., Komine, F., Izawa K. , Kunisaki R., Setoyama M., Nishimori H., Natsume A., Makoto Sunamura M., Lozonshi L., Saitoh I.,Tokino T., ,Asano S., Nakamura Y. , Tani K. Antiangiogenic activity of BAI1 in vivo: implications for gene therapy of human glioblastomas Cancer Gene Ther 13: 385-392, 2006
  • Nagano, K., Itagaki, C., Izumi,T., Nunomura, K., Soda, Y., Tani, K., Takahashi, N., Takenawa, T., Isobe, T. Rb plays a role in survival of Abl-dependent human tumor cells as a downstream effector of Abl tyrosine kinase. Oncogene 25:493-502,2006
  • Nakayama M, Both GW, Banizs B, Tsuruta Y, Yamamoto S, Kawakami Y, Douglas JT, Tani K, Curiel DT, Glasgow JN. An adenovirus serotype 5 vector with fibers derived from ovine atadenovirus demonstrates CAR-independent tropism and unique biodistribution in mice.Virology 350:103-115,2006
  • Kunisaki, R., Ikawa, S., Maeda, T., Nakazaki, Y., Kurita, R., Harata, M., Shutoh, Y., Bai, S.Y., Soda,Y.,Tanabe, Y., Dohi, T., Kato, R., Ikawa, Y., Sekihara, H., Asano, S., Tani, K., p51/p63, a novel p53 homologue, potentiates p53 activity and is a human cancer gene therapy candidate . J Gene Med. 8:1121-1130,2006
  • Nakazaki,Y., Hase,H., Inoue,H., Beppu,Y., Meng Xin K, Sakaguchi,G., Ryo Kurita, R., Asano,S., Nakamura,Y., Tani,K. Serial analysis of gene expression in progressing and regressing mouse tumors implicates the involvement of RANTES and TARC in antitumor immune responses. Mol Ther 14:599-606,2006
  • Kurita, R.,Sasaki, E., Yokoo, T., Hiroyama, T., Takasugi, K., Imoto, H., Izawa, K., Dong,Y., Hashiguchi, T., Soda, Y., Maeda, T., Suehiro, Y. Tanioka, Y.,Nakazaki,Y., Tani, K. Tal1/scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) ES cells. Stem Cells 24:2014-2022,2006
  • Moon Y, Cho SG, Lee JW, Min WS, Kim CC, Lee HK, Kim YG, Chang HS, Chae HS, Kim HY, Tani K., Protective effect of irradiated renal carcinoma expressing hepatitis B surface antigen against renal-cell carcinoma-mediated tumors.Cancer Biother Radiopharm. 21:211-216, 2006.
  • Ishii, H., Mimori, K., Inoue, H., Inageta, T., Ishikawa, K., Semba, S. Druck, T., Trapasso,F., Tani, K., Veccchione, A., Croce, C.M., Mori, M., Huebner, K. Fhit Modulates the DNA Damage Checkpoint Response. Cancer Res. 66:11287-11292, 2006.
  • Horn, P.A., Tani, K., Martin, U., Niemann, H. Meeting Report: Nonhuman Primates: Embryonic stem cells and transgenesis. Cloning and Stem Cells 8:124-129,2006.
  •  Zang, X., Soda, Y.,Takahashi, K.,Bai, Y., Mitsuru,A.,Igura,K.,Satoh, H., Yamaguchi,S., Tani, K., Tojo, A., Takahashi, T. Successful immortalization of mesenchymal progenitor cells derived from human placenta and the differentiation abilities of immortalized cells Biochem Biophys Res Commun 351: 853-859, 2006
  •  Tanaka, T., Okabe, T., Gondo,S., Fukuda, M., Yamamoto, M., Umemura, T., Tani, K., Nomura, M., Goto, K., Yanase, T., Nawata, H. Modification of glucocorticoid sensitivity by MAP kinase signaling pathways in glucocorticoid-induced T-cell apoptosis. Exp. Hematol. 34:1542-1552, 2006.
  •  Nakayama M, Muta H, Somada S, Maeda T, Mutoh T, Shimizu K, Suehiro Y, Hisano T, Kurita R, Shiraishi T, Mori M, Yoshikawa Y, Tsunetomi N, Uchida A , Tani K. A case of Cronkhite-Canada Syndrome associated with schizophrenia Int. Med. 46:175-180, 2007.
  •  Suehiro Y, Tachikawa Y, Abe Y, Ohshima K, Muta K, Tani K. Epithelioid hemangioendothelioma presenting with severe myelofibrosis and a high serum hyaluronan level. Eur J Haematol 79:349-353, 2007
  • Kudo S, Konda R, Obara W, Kudo D, Tani K, Nakamura Y, Fujioka T. Inhibition of tumor growth through suppression of angiogenesis by brain-specific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma.Oncol Rep 18:785-791, 2007
  •  Maeda T, Sugano M, Guan JZ, Oyama J, Higuchi Y, Makino N, Hatakenaka M, Muta H, Nakayama M, Nakazaki Y, Kurita R, Hiroyama T, Suzuki T, Tani K. Familial Turner mosaicism 46XX/45XO with brain calcification. J Neuropsychiatry Clin Neurosci. 19:342-343,2007.
  •  Tanaka, T., Gondo, S., Okabe, T., Shirohzu, H., Morinaga, H., Nomura, M., Tani, K.,Takayanagi, R., Nawata, H., Yanase, T. SF-1/Ad4BP transforms human bone marrow mesenchymal cells into steroidogenic cells. J Mol Endocrinol. 39:343-350, 2007
  •  Sun,X,m Somada, S., Shibata,K., Muta, H., Yamada, H., Yoshihara,H., Hobnad, K., Nakamura, K. Takayanagi, R., Tani, K.,Podack, E., Yoshikai, Y.A Critical Role of CD30 Ligand/CD30 in Controlling Inflammatory Bowel Diseases in Mice. Gastroenterology.134:447-458, 2007

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業績リスト(欧文)2000~2005年

  • Tani, K., Nakazaki,Y., Hase,H., Takahashi, K., Azuma, M., Ohata, J., Oiwa, M., Kitamura, R., Masunaga, A., Maekawa, T., Satoh,N., Adachi, D., Soda, Y., Watari, K., Tojo,A., Yamashita,N., Yoshikawa, H., Tomikawa,S., Eriguchi, M., Wakumoto, Y., Hanazawa, K., Shuin, T., Kawai ,K., Hamada,H., Okumura, K., Akaza, H., Fujime, M., Clift, S., Ando, D., Sherwin, S., Mulligan, R., and Asano S. Progress reports on immune gene therapy for stage IV renal cell carcinoma using lethally irradiated GM-CSF transduced autologous renal cancer cells. Cancer Chemother Pharmacol 46 ( Suppl ) S73-S76, 2000
  • Hase, H., Tani, K., Nagayama, H., Watari, K., Takahashi, S., Ooi, J., Shirafuji, N., Izeki, T., Nakazaki, Y., Yamashita,T., Nakamura, T., Masunaga, A., Maekawa, T., Tojo, A. and Asano,S. . Case Report: The avalability of TCR-Vァ repertoires analysis with RT-PCR methods for the early detection of pulmonary relapsed T-cell malignancy after the autologous stem cell transplantation. Am J Hematol 64: 124-127, 2000
  • Watari , K., Tojo , A., Nagamura-Inoue ,T., Nagamura, F., Takeshita, T., Fukushima, T., Motoji, T., Tani, K. and Asano S. Identification of a melanoma antigen, PRAME, as a BCR/ABL-inducible gene. FEBS lett 466:367-371, 2000
  • Kawai, K., Tani, K., Asano, S. and Akaza, H. Ex vivo gene therapy using granulocyte-macrophage colony-stimulating factor transduced tumor vaccines. Mol Urol 4:43-47, 2000
  • Tanabe T. Takata I. Kuwabara T. Warashina M. Kawasaki H. Tani K. Ohta S. Asano S. Taira K.: Maxizyme, novel allosterically controllable ribozymes, can be designed to cleave various substrates. Biomacromolecules 1:108-117, 2000
  • Machida,U., Tojo,A., Ooi,J., Iseki,T., Nagayama,H.,Shirafuji,N., Sawada,M., Nakayama, K., Tani, K., Asano, S. Refractory facial cellulitis following cosmetic fhinoplasty after cord blood stem cell transplantation. Int J Hematol 72:98-100, 2000
  • Machida,U., Tojo,A., Takahashi, S., Iseki, T., Nagayama,H., Shirafuji, N.., Mori, S., Wada,Y., Ogami, K., Yamada,Y., Sakamaki, H., Maekawa,T., Tani,K., Asano, S. The effect of G-CSF administration in healthy donors before bone marrow harvesting. Br. J. Haematol, 108: 747-753, 2000
  • Watari, K., Tojo, A., Nagamura-Inoue, T., Matsuoka, M., Irie, S., Tani, K., Yamada, Y., Asano, S. Hyperfunction of neutrophils in a BCR/ABL-negative chronic myeloid leukemia: A case report with in vitro studies. Cancer 89: 551-560, 2000
  • Tanabe T. , Kuwabara T. ,Warashina M.,Tani K. Taira, K., Asano S. : Oncogene inactivation in a mouse model. Nature 406:473-474, 2000
  • Wu MS, Tani K, Sugiyama H, Hibino H, Izawa K, Tanabe T, Nakazaki Y, Ishii H, Ohashi J, Hohjoh H, Iseki T, Tojo A, Nakamura Y, Tanioka Y, Tokunaga K, Asano S.MHC (Major histocompatibility Complex)-DRB genes and polymorphisms in common marmoset. J Mol Evol. 51:214-222,2000
  • Yusa, N., Watanabe, K., Yoshida, S., Shirafuji, N., Shimomura, S., Tani, K., Asano, S., Sato, N. Transcription factor Sp3 activates the liver/bone/kidney-type alkaline phosphatase promoter in hematopoietic cells. J Leukoc Biol. 68:772-7, 2000
  • Wang, Z., Sumimoto, H., Tani, K., Kang, X., Nakazaki, Y., Asano, S. IL-12 synergizes with B7-1 enhance the antitumor immunity in C57BL/6 mice. Int J Mod Cancer Therapy 3: 51-53,2000
  • Hibino,H., Tani,K., Ikebuchi, K., Suzuki, S., Wu, M.S., Sugiyama, H., Izawa, K., Hase, H., Nakazaki, Y., Tanabe, T., Ooi, J., Izeki, T., Tojo, A., Tanioka, Y. and Asano, S. Haematopoietic progenitor cells from common marmoset as targets of gene transduction by retroviral and adenoviral vectors. Eur J Haematol 66:272-280,2001
  • Tomonari A, Tojo A, Iseki T, Ooi J, Nagayama H, Ogami K, Maekawa T, Shirafuji N, Tani K, Asano S. Severe autoimmune thrombocytopenia after allogeneic bone marrow transplantation for aplastic anemia. Int J Hematol 74: 228-232,2001
  • Ooi, J., Iseki, T., Nagayama, H., Tomonari, A., Ito, K., Shirafuji, N.,Tojo, A., Tani, K., Asano, S. Unrelated cord blood translplantation for adult patients with MDS-related secondary acute myeloid leukaemia. Br J Haematol. 114:834-836, 2001
  • Inazawa T, Tanabe T., Yamada H., Nakaoka T., Hashimoto, Yamasaki T., Kotaki H., Tani K., Asano S., and Yamashita N. Glucorticoid-regulated expression of exogenous human growth hormone gene in rats. Molecular Therapy 4:267- 272, 2001
  • Ooi, J., Iseki, T., Adachi.D, Yamashita, T., Tomonari, A., Tojo, A., Tani, K., Asano, S. Successful allogeneic bone marrow transplantation for hepatosplenic gd T cell lymphoma. Hematologica 86: E25,2001
  • Kuwabara, T., Tanabe, T., Warashina,M., Kang X.,, Tani,K., Taira, K., and Asano,S. Allosterically controllable maxizyme-mediated suppression of progression of leukemia in mice. Biomacromolecules 2: 1220-1228, 2001
  • Ooi, J., Iseki, T., Ito, K., Mori, Y., Sato, H., Takahashi, T., Ishii, N., Tomonari, A., Tojo, A., Tani, K., Asano, S. Successful unrelated cord blood transplantation for relapse after autologous transplantation in non-Hodgkinユs lymphoma. Leuk Lymphoma 43:653-655, 2002
  • Nagayama, H., Misawa, K., Tanaka, H., Ooi, J., Iseki, T., Tojo, A., Tani, K.,Yamada, Y., Kodo, H., Takahashi, TA., Yamashita, N., Shimazaki,, S. and Asano, S. Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim. Bone Marrow Transplantation 29: 197-204, 2002
  • Duda, DG., Sunamura, M., Lozonschi, L., Yokoyama, T., Yatsuoka, T., Motoi,F., Horii, A., Tani, K., Asano, S., Nakamura, Y., Matsuno, S. Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumor angiogenesis. Br. J. Cancer 86: 490-496, 2002
  • Ohata, J., Sakurai, J., Saito, K., Tani, K.,Asano, S., Azuma, M. Differential graft-versus-leukemia effect by CD28 and CD40 costimulatory blockade after graft versus-host disease prophylaxis. Clin Exp Immunol 129:61-68, 2002
  • Tani, K.Immunotherapy using GM-CSF gene for metastatic renal cell cancer. International Symposium: Cancer Gene Therapy. 213-223, 2002 (Eds) Ochiai, T., Matsubara, H.
  • Tomonari, A., Shirafuji, N., Iseki, T., Ooi, J., Nagayama, H., Masunaga, A., Tojo, A.,Tani, K. and Asano, S. Acquired pulmonary alveolar proteinosis after umbilical cord bloodTransplantation for acute myeloid leukemia. American Journal of Hematology 70:154-157,2002
  • Nagayama, H., Ooi, J., Tomonari, A., Iseki, T., Tojo, A., Tani, K., Takahashi, T.A. and Asano, S. Severe immune dysfunction after lethal neutron irradiation in a JCO nuclear facility accident victim. Int. Journal of Hematology, 76:157-164, 2002
  • Kawai, K., Tani,K., Yamashita, N., Tomikawa,S., Eriguchi, M., Fujime, M., Okumura, K., Kakizoe, T., Clift, S., Ando,D., Mulligan, R., Yamauchi, A., Noguchi, M., Asano, S. and Akaza, H. Advanced renal cell carcinoma treated with granulocytemacrophage colony-stimulating factor gene therapy: A clinical course of the first Japanease experience. Int. Journal of Urology. 9, 462-466, 2002
  • Tomonari, A., Iseki, T., Ooi, J., Takahashi, S., Ishii, T., Takahashi, T., Shindo, M., Nagamura, F., Uchimaru, K., Nagayama, H., Shirafuji, N., Tojo, A., Tani,K., Asano, S., Using related donors other than genotypically HLA-matched siblings in allogeneic hematopoietic stem cell transplantation for hematologic disease: a single institution experience in Japan. Int J Hematol. 76:354-359, 2002.
  • Tomonari, A., Iseki, T., Ooi, J., Nagayama, H., Sato, H., Takahashi, T., Ito, K., Nagamura, F., Uchimaru, K., Takahashi, S., Shirafuji, N., Tojo, A., Tani, K., Asano, S. Second allogeneic hematopoietic stem cell transplantation for leukemia relapse after first allogeneic transplantation: outcome of 16 patients in a single institution. Int J Hematol. 75:318-323, 2003.
  • Tomonari, A., Shirafuji, N., Tojo, A., Iseki, T., Ooi, J., Koyama, I., Tani:, K., Asano, S. Acute myelogenous leukemia M5b developed during clinical remission of Castleman disease.Int J Hematol. 77:274-276, 2003.
  • Tomonari, A., Tojo, A., Adachi, D., Iseki, T., Ooi, J., Shirafuji, N., Tani, K., Asano, S.Acute disseminated encephalomyelitis (ADEM) after allogeneic bone marrow transplantation for acute myeloid leukemia. Ann Hematol. 82:37-40, 2003.
  • Tomonari, A., Iseki, T., Ooi, J., Takahashi, S., Shindo, M., Ishii, K., Nagamura, F., Uchimaru, K., Tani, K., Asano, S. Cytomegalovirus infection following unrelated cord blood transplantation for adult patients: a single institute experience in Japan.Br J Haematol. 121:304-311, 2003.
  • Bai, Y., Soda, Y., Izawa, K., Tanabe, T., Kang, X., Tojo, A., Hoshino,H., Miyoshi, H., Asano, S. and Tani, K. Effective transduction and stable transgene expression in human blood cells by a third-generation lentiviral vector. Gene Ther 10:1446-1457, 2003
  • Kojima,T., Yamazaki,T., Tamura,Y., Ogura,S., Hizawa,N., Yamaguchi,E.,Tani,K., Kinoshita,I., Nishimura,M and Dosaka-Akita ,H. Tumor-derived Gp96 combined with GM-CSF gene-transduced tumor cells inhibit tumor growth in mice through migration and maturation of CD11c+ cells. Human Gene Ther. 14: 715-728, 2003
  • Tomonari, A., Tojo, A., Iseki, T., Ooi, J., Hase, H., Shirafuji, N.,Tani, K. and Asano, S. Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy. Acta Hematol, 109: 90-94, 2003.
  • Yoshida,Y., Nakamura,T.,Komoda,M., Sato,H., Suzuki, T.,Tsuzuku, J.,Miyasaka, T.,Yoshida, E., Umemori, H., Kunisaki, R.,Tani,K., Ishii, S.,Mori, S.,Suganuma,M., Noda, T. and Yamamoto, T.,Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Gene Dev 17:1201-1206,2003
  • Nagayama, H,Sato,K., Morishita, M.,Uchimaru, K.,Oyaizu, N.,Inazawa, T.,T. Yamasaki, T.,Enomoto, M.,Nakaoka, T.,Nakamura, T.,Maekawa, T.,Yamamoto, A.,Shimada, S.,Saida, T.,Kawakami, Y.,Asano,S., Tani, K.,Takahashi T.A.and Yamashita., N. Results of phase I clinical study using autologous tumor-lysatepulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2, Melanoma Res .13: 521-530, 2003
  • Oshima, K.,Kawasaki, H., Soda, Y., Tani,K., Asano, S.,Taira, K. Maxizymes and Small Hairpin-type RNAs that are driven by a tRNA promoter specifically cleave a chimeric gene associated with leukemia in vitro and in vivo. Cancer Res 63: 6809-6814, 2003
  • Nagamura, F., Takahashi, T., Takeuchi, M., Iseki, T., Ooi, J., Tomonari, A., Uchimaru, K., Takahashi, S., Tojo, A., Tani, K., Asano, S., Drug interactions: effect of cyclophosphamide on serum cyclosporine levels at the conditioning of hematopoietic stem cell transplantation. Bone Marrow Transplant. 32: 1051-1058,2003.
  • Tomonari, A., Iseki, T., Takahashi, S., Ooi, J., Takasugi, K., Shimohakamada, Y., Ohno, N., Nagamura, F., Uchimaru, K., Tani, K., Tojo, A., Asano, S. Varicella-zoster virus infection in adult patients after unrelated cord blood transplantation: a single institute experience in Japan. Brit J Haematol. 122: 802-805, 2003.
  • Tomonari, A., Takahashi, S., Iseki, T., Ooi, J., Yamada, T., Takasugi, K., Shimohakamada, Y., Ohno, N., Nagamura, F., Uchimaru, K., Tani, K., Tojo, A., Asano, S. Herpes simplex virus infection in adult patients after unrelated cord blood transplantation: a single institute experience in Japan. Bone Marrow Transplant. 33: 317-320, 2004.
  • Maeda, T., Hatakenaka, M., Muta, H., Nakayama, M., Nakazaki, Y., Hiroyama, T., Suzuki,T., Tani, K., Clinically mild, atypical, and aged craniofacial syndrome is diagnosed as Crouzon syndrome by identification of a point mutation in the fibroblast growth factor receptor 2 gene (FGFR2). Intern Med 43: 432-435, 2004
  • Soda Y, Tani K, Bai Y, Saiki M, Chen M, Izawa K, Kobayashi S, Takahashi S, Uchimaru K, Kuwabara T, Warashina M, Tanabe T, Miyoshi H, Sugita K, Nakazawa S, Tojo A, Taira K, Asano S: A novel Maxizyme vector targeting a bcr-abl fusion gene induced specific cell death in Philadelphia chromosome-positive lymphoblastic acute leukemia. Blood104: 356-363, 2004
  • Izawa, K., Tani, K., Nakazaki, Y., Hibino, H., Sugiyama, H., Kawasaki, A., Sasaki, E., Nishioka, C., Ishii, H., Soda, Y., Yagita, H., Tanioka, Y., Tojo, A., Asano, S., Hematopoietic Activity of Common Marmoset CD34 Cells Isolated by a Novel Monoclonal Antibody MA24. Exp Hematol 32: 843-851, 2004
  • Maeda, T., Shiokawa, S., Yoshikawa, Y., Hiroyama T., Nakajima Y., Muta, H., Nakayama,M., Nakazaki, Y., Akizuki, S., Shimizu, K., Mutoh, T., Somada, S., Kurita, R., Shiratsuchi, M., Makino, N., Nishimura, J. and Tani, K. Successful treatment of pure red cell aplasia of an 88-year-old case with cyclosporin A and erythropoietin after thymectomy. Haematologica 89(6 Suppl):ECR17, 2004
  • Harata M, Soda Y, Tani K*, Ooi J, Takizawa T, Chen M, Bai Y, Izawa K, Kobayashi S, Tomonari A, Nagamura F, Takahashi S, Uchimaru K, Iseki T, Tsuji T, Takahashi TA, Sugita K, Nakazawa S, Tojo A, Maruyama K, Asano S: CD19-targeting liposomes containing imatinib efficiently kill Philadelphia chromosome-positive acute lymphoblastic leukemia cells. Blood 104: 1442-1449, 2004.
  • Maeda, T., Mutoh, T., Muta, H., Nakayama, M., Nakajima, Y., Ikuta, T., Yasuda, M., Etoh, T.,Shimizu, K.,Nakazaki, Y.,Hiroyama, T., Somada,S.,Kurita, R., Tani, K., Shiratsuchi, M., Nishimura , J., An 85-year-old Japanese female with Ph-1-positive CML with del (5q) successfully treated by intermittent imatinib therapy. J Am Geriatr Soc. 52: 1783-1784, 2004.
  • Maeda,T., Chijiiwa, Y., Tsuji,H., Sakoda, S., Tani, K. Suzuki, T. Somatic DNA recombination yielding circular DNA and deletion of a genomic region in embryonic brain. Biochem Biophys Res Commun 319: 1117-1123, 2004
  • Tani, K., Azuma, M., Nakazaki, Y., Oyaizu, N., Hase,H.,Ohata, J., Takahashi,K., Oiwa-Monna, M.,Hanazawa,K., Wakumoto,Y., Kawai,K., Noguchi,M.,Soda,Y., Kunisaki, R., Watari,K., Takahashi,S., Machida,U., Satoh,N., Tojo,A., Maekawa, T., Eriguchi, M., Tomikawa, S., Tahara, H., Inoue, Y., Yoshikawa, H., Yamada, Y., Iwamoto, A.,Hamada, H., Yamashita, N. Okumura, K., Kakizoe, T., Akaza, H., Fujime, M. Clift, S., Ando, D., Mulligan, R. and Asano, S. Phase I Study of Autologous Tumor Vaccines Transduced with the GM-CSF Gene (GVAXa) in Four Patients with Stage IV Renal Cell Cancer in Japan:Clinical and Immunological Findings. Mol Ther 10: 799-816, 2004.
  • Ooi, J., Iseki, T., Takahashi, S., Tomonari, A., Takasugi, K., Uchiyama, M., Konuma,T., Futami, M., Nomura, A., Nakayama, S., Soda, Y., Ohno, N. Nagamura, F., Uchimaru, K., Tojo, A., Tani, K., Asano, S. Unrelated cord blood transplantation after myeloablative conditioning in patients over the age of 45 years. B rit J Haematol 126: 711-714, 2004.
  • Takahashi, S., Iseki, T., Ooi, J., Tomonari, A., Takasugi,K., Shimohakamada,Y., Yamada,T., Uchimaru1,K., Tojo,A., Shirafuji, N., Kodo, H., Tani, K., Takahashi, T., Yamaguchi,T., Asano, S. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematological malignancies. Blood 104: 3813-3820, 2004
  • Cho, S.G., Shuto, Y., Soda, Y., Nakazaki, Y., Izawa, K., Uchimaru, K., Takahashi, S., Tani, K., Tojo, A., Asano, S., Anti-NK cell treatment induces stable mixed chimerism in MHC-mismatched, T-cell depleted, nonmyeloablative bone marrow transplantation.Exp. Hematol. 32: 1246-1254, 2004  
  • Maeda, T., Oyama, J., Mukai, Y., Satoh, S., Sugano, M., Makino, N. and Tani, K. Cardiac dysfunction with severe anemia in an aged case. J Am Geriatr Soc. 53: 361-362, 2005
  • Nakashima,Y., Shiratsuchi, M., Abe ,Y., Muta, K., Tani, K., Shiokawa, S., Nishimura, J. Sustained molecular remission by non-myeloablative stem cell transplantation after autologous hematopoietic stem cell transplantation in a patient with multiple myeloma. Leuk Lymphoma. 46:1217-1222, 2005.
  • Sasaki, E., Hanazawa, K., Kurita, R., Akatsuka, A., Yoshizaki, T., Ishii, H., Tanioka, Y., Ohnishi, Y., Suemizu, H., Sugawara, A., Tamaoki, N., Izawa, K., Nakazaki, Y., Hamada, H., Suemori, H., Nakatsuji, N., Okano, H. and Tani, K. Establishment of Novel Embryonic Stem Cell Lines Derived from the Common Marmoset (Callithrix jacchus) Stem Cells 23:1304-1313, 2005
  • Nishimura H. , Yajima T., Muta H., Podack E.R., Tani K., and Yoshikai Y. :A novel role of CD30/CD30L signaling in the generation of long-lived memory CD8+T cells .J.Immunol. 175:4627-4634, 2005.

▲ページ先頭へ戻る

業績リスト(欧文)1990-1999年

  • Morisaki, T,Tani,K.,Kodo, H.,Shirafuji,N.,Watari,K.,Matsuda,S.,Tsutsumi, H., Kanno,H.,Ieki,R.,Fujii,H.,Tagami,R.,Asano,S.,Takaku,F. and Miwa,S. Bone marrow harvesting for autologous transplantation. Acta Haematol.Jpn 53:664-667, 1990
  • Shirafuji, N.,Matsuda, S.,Ogura, H.,Tani,K.,Kodo, H.,Ozawa, K.,Nagata,S., Asano, S. and Takaku, F. 1990 Granulocyte colony-stimulating factor stimulates human mature neutrophilic granulocytes to produce interferon-α. Blood 75:17-19, 1990
  • Ogura, H.,Tani,K.,Kozai,Y.,Watari,K.,Kodo,H.,Ozawa,K.,Asano,S. and Takaku, F. Effect of interferon-α in patients with chronic myelogenous leukemia in the accelerated phase: cytogenetic and molecular studies. Jpn. J. Cancer Res.81:682-686, 1990
  • Tani,K.,Ozawa,K.,Ogura,H.,Shimane,M.,Shirafuji,N.,Tsuruta,T.,Yokota,J.,Nagata,S., Ueyama,Y. Takaku,F. and Asano,S. Expression of granulocyte and granulocyte-macrophage colony-stimulating factors by human nonhematopoietic tumor cells. Growth Factors 3: 325-331, 1990
  • Ogura,H.,Tani,K.,Ozawa,K.,Nagata,S.,Asano,S.and Takaku,F. Implantation of gene-tically manipulated fibroblasts into mice as antitumor-interferon-therapy. Cancer Res. 50:5102-5106, 1990
  • Sato, N., Mizukami, H., Tani, K., Asano, S. and Takaku, F. Regulation of alkaline phosphatase activity in neutrophilic granulocytes. Acta Haematol Jpn 53: 1569-1576, 1990
  • Sato, N., Mizukami, H., Tani, K. and Asano, S. Regulation of mRNA levels of alkaline phosphatase gene in neutrophilic granulocytes by granulo cyte colony-stimulating factor and retinoic acid. Eur J Haematol 46:107-111, 1991
  • Tani, K., Ozawa, K., Tsuruta, T., Shimane, M., Watari, K., Ogura, H., Takahashi, S., Sato, N. and Asano,S. Possible pathophysiological roles of G-CSF in myelodysplastic syndromes (MDS): A case report. in Myelodysplastic syndrome and cytokines. Miyazaki, T., Takaku, F. and Uchino, H.(eds)pg 161-166,. Elsevir, Amsterdam, 1991
  • Asano, S., Ogura, H., Tani, K. Inoue, T., Tojo, A. and Ozawa, K. Several new approaches to improvement of interferon-alpha therapy in chronic myelogenous leukemia. Eur J Cancer 27( suppl) 4, S21-25, 1991
  • Ozawa, K., Takahashi, K., Nishikawa, M., Yoshikubo, T., Shimane, M., Takahashi, T., Takahashi, S., Horiuchi, N., Tsuruta, T., Watari, K., Tojo, A., Tani, K. and Asano, S. Regulatory production of granulocyte colony-stimulating factor (G-CSF) by stromal cells.in hematopoietic growth factors molecular biology to clinical applications of rG-CSF. (eds) Quesenberry, P. Asano, S. and Saito, K., Excerpta Medica, Amsterdam, 1991
  • Tani, K., Ozawa, K., Ogura, H. and Asano, S. Implantation of genetical ly manipulated fibroblasts into mice as a model of cytokine supplementation gene therapy using human G-CSF and IFN-alpha cDNAs. Molecular approaches to the Study and Treatment of Human Diseases. Yoshida & Wilson (eds) pg419-428, Elsevier, Amsterdam, 1992
  • Irie, S., Ogura, H., Okamoto, S., Tojo, A., Tani, K., Ikebuchi, K., Sato, N., ozawa, K., Asano, S. Alternation therapy with Antileukemic agents and recombinant human granulocyte colony-stimulating factor for refractory anemia with express of blasts in transformation. The Amer J Med Sci, 303:316-318, 1992
  • Tsurumi, H., Tani, K., Tsuruta, T., Shirato, R., Matsudaira, T., Tojo, A., Wada, C., Ozawa, K. and Asano, S. Adult T-cell leukemia developing immunosuppressive treatment in a renal transplant recipient. Am. J. Hematol 41:292-294, 1992
  • Tsurumi,H., Tani, K., Tajika, K., Irie, S., Kobayashi, Y., Tojo, A., Okamoto, S., Ozawa, K., Moriwaki, H., Muto, Y. and Asano, S. Spontaneous bacterial peritonitis due to clostridium perfringens in a patient with liver cirrhosis and pure red cell aplasia. Gastroenterol Jpn. 27:662-667, 1992
  • Matsudaira, T., Kodo,H., Okamoto,S.,Tani,K., Tojo,A., Ozawa,K., Asano,S. The alloantigen-specific immunosuppressive activity of estradiol-chlorambucil conjugate (KM2210) and itsbeneficial effect on allogeneic bone marrow transplantation in mice. Transplantation 54:676-681, 1992
  • Inoue,T.,Tani,K.,Tajiri,M., Ishida,Y.,Seguchi,M., Tanaka, H., Asano,S., Kaneko, T. and Matsumoto, N. A case report of familial cyclic neutropenia. Tohoku J exp Med 167: 107-113, 1992
  • Inoue,T.,Tojo,A.,Tsuchimoto,D.,Okamoto,S.,Ogura,H.,Tani,K.,Ozawa,K.,Shibuya,M.,Asano,S. Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to alpha-interferon in chronic myelo-genous leukemia. Leukemia 6:948-951, 1992
  • Uemura,N., Ozawa, K., Tojo., Takahashi, K., Okano, A., Karasuyama, H., Tani, K., Asano, S. Acquisition of IL-3-independence in FDC-P2 cells after transfection with the activated c-H-ras gene using a bovine papillomavirus-based plasmid vector. Blood 80:3198-3204 1992
  • Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani, K. and Seldin, M.F. Chromosomal mapping of the high affinity Fcγreceptor gene. Immunogenetics 35:279-282, 1992
  • Takahashi,S., Okamoto, S., Tani, K., Shimane, M., Nishiwaki, K., Yujiri, T., Miyakoshi, S., Ueda, A., Aoki, Y., Inoue, T., Tsuruta, T., Kobayashi, Y., Tojo, A., Ikebuchi, K., ozawa, K. and Asano, S. Effective prevention of relapse following allogeneic bone marrow transplantation (BMT) with recombinant human glycosylated G-CSF-combined regimen in drug resistant acute myeloid leukemia. The mechanism and new approach on drug resistance of cancer cells. Miyazaki, T., Takaku, F. and Sakurada, K.(eds) pg 303-310,Elsevier, Amsterdam, 1993
  • Uemura, N., Ozawa, K., Tojo, A., Takahashi, K., Tani, K. and Asano, S. Increased radioresistance of FDC-P2 myeloid cells transformed by the activated c-H-ras gene. The mechanism and new approach on drug resistance of cancer cells. Miyazaki, T., Takaku, F. and Sakurada, K.(eds) pg 229-232,Elsevier, Amsterdam, 1993
  • Inoue, T., Tojo, A., Ogura, H., Takahashi, S., Kobayashi, Y., Okamoto, S., Tani, K., Ozawa, K. and Asano, S. Combined therapy with interferon-α and methotrexate for the treatment of chronic myelogenous leukemia. The mechanism and new approach on drug resistance of cancer cells. Miyazaki, T., Takaku, F. and Sakurada, K.(eds) pg 279-282, Elsevier, Amsterdam, 1993
  • Nishikawa,M.,Ozawa,K.,Tojo,A.,Yoshikubo,T.,Tani,K.,Ikebuchi,K.,Nakauchi,H., Asano,S. Changes in hematopoiesis-supporting ability of C3H 10T1/2 mouse embryo fibroblasts during differentiation. Blood 81:1184- 1192, 1993
  • Tani, K., Ogura, H., Inoue, T., Tojo, A., Ozawa, K. and Asano, S. 1993Clinical and Biological aspects of interferon-α in the treatment of chronic myelogenous leukemia. Gann Monograph on Cancer Research 40: 145-154, 1993
  • Tani, K., Ozawa, K., Ogura, H., Takahashi, S., Takahashi, K., Tsuruta, T., Okano, A., Akiyama, Y., Yoshibubo, T., Shimane, M. and Asano, S. The production of grnulocyte colony-stimulating factor and interleukin 6 by human bone marrow stromal cells in aplastic anemia. Tohoku J. Exp. Med. 169: 325-334, 1993
  • Uemura, N., Ozawa, K., Takahashi, K., Tojo, A., Tani, K., Harigaya, K., Suzu, S., Motoyoshi, K., Matsuda, H., Yagita, H., Okumura, K., Asano, S. Binding of membrane-anchored macrophage colony-stimulating factor (M-CS F) to its receptor mediates specific adhesion between stromal cells and M-CSF-receptor-bearing hematopoietic cells. Blood 82: 2634-2640, 1993
  • Kobayashi, K., Yang, J., Shindo, E., Tojo, A., Tani, K., Ozawa, K., Asano, S. HRX gene rearrangement in acute lymphoblastic leukemia (ALL) after adjuvant chemotherapy of breast cancer. Blood 82: 3220-3221, 1993
  • Bakic, M., Ozawa, K., Uemura, N., Nishikawa, M., Tojo, A., Takahashi, K.,Tani, K., Zaike, Y., Ikebuchi, K., Asano, S. Sustained c-kit expression in a human erythroleukemia cell line (HEL) after megakaryocytic differentiation induced by 12-o-tetradecanoylphorbol-13-acetate (TPA). Leukemia Res 17: 1079-1082, 1993
  • Tani, K., Morishita, K., Fukuhara, S., Inoue, T., Kobayashi, Y. and Asano, S. Molecular analysis of leukemia and lymphoma. The Role of Molecular Biology in Clinical Medicine. 1993: 108-114. (eds) Asano, S and Lim, K. E.,SP-Munda, Kuala Lumpur.
  • Tani, K. and Asano,S. Current status of gene therapy in Japan. The Role of Molecular Biology in Clinical Medicine. 1993: 115-120. (eds) Asano, S and Lim, K. E.,SP-Munda, Kuala Lumpur.
  • Takahashi, S., Shirafuji, N., Ikebuchi, K., Tani, K., Shimane, M., Matsudaira, T., Irie, S., Tsuruta, T., Matsuishi, E., Ogura, H., Kouzai, Y., Kodo, H., Tojo, A., Satoh, N., Ozawa, K., Asano, S. Recombinant human glycosylated granulocyte colony-stimulating factor (RhG-CSF)-combined regimen for allogeneic bone marrow transplantation in refractory acute myeloid leukemia. Bone Marrow Transplant 13: 239-245, 1994
  • Tani, K., Yoshikubo, T., Ikebuchi, K., Takahashi, K., Tsuchiya, T., Takahashi, S., Shimane, M., Ogura, H., Tojo, A.,Ozawa, K., Takahara, Y., Nakauchi, H., Markowitz, D., Bank, A., Asano, S. Retrovirus-mediated gene gene transfer of human pyruvate kinase (PK) cDNA into murine hematopoietic cells: Implication for gene therapy of human PK deficiency. Blood 83: 2305-2310, 1994
  • Tani, K.,Lin, T., Hibino, H., Nagayama, H., Takahashi, S., Takahashi, K., Shimane, M., Kanegae, Y., Saitoh, I., Ikebuchi, K., Tojo, A., Ozawa, K., Nakauchi, H., Dranoff, G., Mulligan, R. and Asano, S. Introduction of foreign genes into hematopoietic cells using retrovirus and adenovirus vectors. Cancer chemotherapy: Challenges for the Future 9:115-125, (eds) Kimura K., Ota, K., Carter, S.K. & Friedmenn, T., Excerpta Medica, Amsterdam, 1994
  • Asano, S. and Tani, K. Current status of gene therapy in Japan. Cancer chemotherapy: Challenges for the future 9:213-217, (eds) Kimura K., Ota, K., Carter, S.K. & Friedmenn, T., Excerpta Medica, Amsterdam, 1994
  • Shimane, M.,Tani, K., Maruyama, K, Ozawa, K., Asano, S. Molecular cloning and characterization of G-CSF induced gene cDNA. Biochem Biophys Res Commun 199: 26-32, 1994
  • Tamura, A ., Agematsu, K., Mori, T., Kawai, H., Kuratsuji, T., Shimane, M., Tani, K., Asano, S., Komiyama, A. A marked decrese in defensin mRNA in the only case of congenital neutrophil-specific granule deficiency reported in Japan. Int J of Hematol 59: 137-142, 1994
  • Kawachi, Y., Ozaki, S., Sakamoto, Y., Uchida, T., Mori, M., Setsu, K.,Tani,K.,. and Asano, S. Richter's syndrome showing pronounced lymphadenopathy in response to adeministration of granulocyte colony-stimulating factor. Leukemia and Lymphoma 13: 509-514, 1994
  • Aoki, Y., Tani, K., Takahashi, K., Fukushima, M., Ozawa, K., and Asano, S. Regulation of recombinant human granulocyte colony-stimulating factorproduction using herpes simplex virus 1 thymidine kinase gene. Biochem Biophys Res Commun 200: 1245-1251, 1994
  • Watari, K., Ozawa, K., Takjika, k., Tojo, A., Tani, K., Kamachi, S., Takahashi, T., Sekiguchi, S., Nagata, S. and Asano, S. Production of human granulocyte colony stimulating factor by various kinds of stromal cells in vitro detected by enzyme immunoassay and in situ hybridization. Stem Cells 12:416-423, 1994
  • Yoshikubo, T., Ozawa, K., Takahashi, K.,Nishikawa, M., Horiuchi, N., Tojo, A., Tani, K., Kodama, H. and Asano, S. Adhesion of NFS-60 myeloid leukemia cells to MC3T3-G2/PA6 stromal cells induces granulocyte colony-stimulating factor production. Blood 84: 415-420, 1994
  • Suzukawa, K., Parganas, E., Gajjar, A., Abe, T., Takahashi, S., Tani, K., Asano, S., Asou, H., Kamada, N., Yokota, J., Morishita, K., and Ihle, K. J. Identification of a breakpoint cluster region 3' of the ribophorinI gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myeloid leukemia with inv(3)(q21q26). Blood 84:2681-2688, 1994
  • Tani, K., Lin, T., Hibino, H., BNakazaki, Y., Takahashi, S., Nagayama, H., Ozawa, K., Saitoh, I., Mulligan, R., and Asano, S. Transduction of LacZ Gene into leukemia cells using viral vectors of retrovirus and adenovirus. Leukemia 9, Suppl 1, 1995
  • Baba, M., Hasegawa, H., Nakayabu, M., Shimizu, N., Suzuki, S., Kamada, N., and Tani, K. Establishment and characteristics of a gastric cancer cell line (HuGC-OOHIRA) producing high levels of G-CEF, GM-CSF, and IL-6: The presence of autocrine growth control by G-CSF. Am. J. Hematol. 49: 207-215, 1995
  • Uemura, N., Ozawa, K., Tani, K., Nishikawa, M., Inoue, S., Nagao, T., Uchida, H., Matsunaga, Y., Asano, S. Pure redo cell aplasia caused by parvovirus B19 infection in a renal transplant recipient. Eur J Haematol 54: 68-69, 1995
  • Cao Xuetao, Wang Jianli, Zhang Weiping, Chen Guoyou, Kong Xiantao, Tani K: Treatment of human hepatocellular carcinoma by fibroblast-mediated human interferon-α gene therpay in combination with adoptive chemoimmuno-therapy. J Cancer Res Clin Oncol 121: 457-462, 1995
  • Tani, K., Asano, S. Gene therapy for hematological disorders. (eds) Robert E Sobol & Kevin J Scanlon, The Internet Book of Gene Therapy: Cancer Therapeutics 147-161, 1995
  • Tsuruta, T., Tani, K., Shimane, M., Ozawa, K., Takahashi, S., Tsuchimoto, D., Takahashi, K., Nagata, S., Sato, N., and Asano, S. Effects of myeloid cell growth factors on alkaline phosphatase, myeloperoxidase, defension and granulocyte colony-stimulating factor receptor mRNA expression in hematopoietic cells of normal individuals and myeloid disorders. Brit. J. Haematol. 92: 9-22, 1996
  • Okamoto, S., Takahashi, S., Inoue, T., Tani, K., Kikuchi, A., Shimizu, H., Nishikawa, T., Ikeda, Y. and Asano, S. Cutaneous chronic graft-versus-hostdisease located to the field of total lymphoid irradiation. Bone Marrow Transplant 17: 111-113, 1996
  • Tani, K.,Hibino, H., Ikebuchi, K., Wu, MS., Nakazaki, Y., Sumimoto, H., Tanabe, T., Takahashi, K., Nakahata, T., Suzuki, S., Tanioka, Y., Mulligan R.C., Asano, S. Common marmoset as a new preclinical animal model for human gene therapy of hematological disorders. Bone Marrow transplantation-Basic and Clinical Studies.201-206,(eds)Ikehara, S.Takaku, F, Good, RA, Spriger-Verlag Tokyo. 1996
  • Oshima, Y., Takahashi, S., Nagayama, H., Nishiwaki, K., Kobayashi, Y., Tojo, A., Okamoto, S., Tani, K., Ozawa, K., Wakabayashi, T., Sato, N., Kobayashi, S., Nakamura, K., Ohya, Y., Nukina, N., Kanazawa, I. and Asano, S. Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfucion (DLT). Bone Marrow Transplant, 19:737-740, 1996
  • Wang, J., Cao, X., Zhang, W. and Tani, K. Treatment of leukemia with fibroblast-mediated interferon-alpha gene therapy alone or in combination with doxorubicin. Leukemia Res, 20: 379-384, 1996
  • Tani, K. Nonimmune hemolytic anemia.Conn's Current Therapy 355-358, (eds) Robert E. Rakel, W.B. Saunders Company 1997
  • Niki,M., Takano, H., Kuno, J., Tani, K., Hibino, H., Asano, S., Ito, Y., Satake, M., Noda, T. The hematopoiesis in the fetal liver is impaired by the targeted mutagenesis of the gene encoding a non-DNA binding subunit of a transcription factor,PEBP2/CBF. Proc Natl Acad Sci USA, 94: 5697-5702, 1997
  • Sumimoto, H., Tani, K., Nakazaki, Y., Tanabe, T., Hibino, H.,Hamada, H., Azuma, M., Asano, S. GM-CSF and B7-1(CD80) costimulatory signals cooperate in the induction of effective antitumor immunity in syngeneic mice. Int J Cancer. 73: 556-561, 1997
  • Watari, K., Ozawa, K., Takahashi, S., Tojo, A., Tani, K., Kamachi, S., Asano, S. Pharmacokinetic studies of intravenous glycosylated recombinant human granulocyte colony-stimulating factor in various hematological disorders: inverse correlation between the half-life and bone marrow myeloid cell pool. Int J Hematol 66: 57-67, 1997
  • Nagamura-Inoue, T., Tojo, A., Ikebuchi, K., Takahashi, S., Ogura, H., Shindoh, E., Nagamura, F., Uemura, N., Watari, K., Irie, S., Setoyama, M., Tajika, K., Nakayama, M., Nagayama, H., Kobayashi, Y., Shirafuji, N., Sato, N., Okamoto, S., Ozawa, K., Tani, K. and Asano, S. Autologous bone marrow transplantation for patients with advanced chronic myelogenous leukemia. Int J Hematol 66: 493-503, 1997
  • Kuwabara, T., Warashina, M., Tanabe, T., Tani, K., Asano, S. and Taira, K.: Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA. Nucleic Acids Research 25:3074-3081, 1997
  • Feldman, E., Ahmed, T., Lutton, J.D., Farley, T., Tani, K., Asano, S., Freund, F. and Abraham, N.G. Adenovirus mediated alpha interferon (IFN-a) gene transfer into hematopoietic stem cells. Stem Cells 15: 386-395, 1997
  • Kumakawa, T., Hibino, H., Tani, K., Asano, S., Futatsugawa, S. and Sera, K. Analysis of bone marrow stromal cell transferred bacterial β-galactosidase gene by PIXE. Int J PIXE 7:45-48, 1997
  • Sumimoto, H., Tani, K., Nakazaki, Y., Tanabe, T., Hibino, H., Wu, M.-S., Izawa, K., Hamada, H., Asano, S.. Superiority of interleukin-12-transduced murine lung cancer cells GM-CSF or B7-1 (CD80) transfectants for therapeutics antitumor immunity in syngeneic immunocompetent mice. Cancer Gene Therapy 5: 29-37, 1998
  • Matsuoka, M., Tani, K. and Asano, S., Interferon-α-inducedG1phase arrest through up-regulated expression of CDK inhibitors, p19 Ink4D and p21Cip1 in mouse macrophages. Oncogene 16: 2075-2086, 1998
  • Nakazaki, Y., Tani, K., Lin, Z-T., Sumimoto, H., Hibino, H., Tanabe, T., Wu, M-S., Izawa, K., Takahashi, S., Hase, H., Tojo, A., Azuma, M., Hamada, H., Mori, S.and Asano, S. Vaccine effect of granulocyte-macrophage colony-stimulating factor or CD80 gene-transduced murine leukemia/lymphoma cells and their cooperative enhancement of antitumor immunity. Gene Therapy 5; 1355-1362, 1998
  • Takahashi, S., Oshima, Y., Okamoto, S-I., Nishiwaki, K., Nagayama, H., Inoue, T., Tojo, A., Tani, K. and Asano, S. Recombinant human granulocyte colony-stimulating factor (G-CSF) combined conditioning regimen for allogeneic bone marrow transplantation (BMT) in standard-risk myeloid leukemia. Am J Hematol 57: 303-308, 1998
  • Ooi, J., Takahashi, S., Tajika, K., Tojo, A., Tani, K. and Asano, S. Imune mediated optic neuritis after allogeneic bone marrow transplantation. Blood. 91: 2619, 1998
  • Koseki, S., Ohkawa, J., Tanabe, T., Tani, K., Asano, S. and Taira, K. The structure of ribozymes expressed from an RNA polymerase III promoter determines functional activity in vivo by influencing their stability. Nucl Acids Symposium Series No.39 145-146, 1998, Oxford University Press
  • Nagamura, F., Nagamura-Inoue, T., Tojo, A., Minamihisamatsu, M., Tanabe, T., Zaike, Y., Tani, K., Saisho, H. and Asano, S. Establishment of noevel cell lines derived from two patients with chronic myelogenous leukemia in blast crisis; IMS-BC1 and IMS-BC2 which exhibit markedly different sensitivity to apoptosis. Int J Hematol 67: 283-294, 1998
  • Kuwabara,T., Warashina1,M., Tanabe,T., Tani,K., Asano, S. and Taira, K. Maxizyme, an allosterically controllable novel tRNAVal-ribozyme, with extremely high and specific activity in cells with a Philadelphia chromosome induces apoptosis only in leukemic cells without affecting normal cells. Mol Cell 2: 617-627, 1998
  • Nagayama,H., Takahashi1, S., Takahashi, T., Ogami, K., Ikebuchi, K., Tojo, A.,Tani,K and Asano,S. IL-2/LAK therapy for refractory acute monoblastic leukemia relapsing after unrelated allogeneic bone marrow transplantation. Bone Marrow Transplant.23; 183-185, 1998
  • Shimane, M., Tani, K., Hibino, H., Setoyama, M., Takahashi , S., Tojo, A., Yodoi, J., and Asano, S., Significant expression of G-CSF induced gene-1(GIG-1) protein in myeloid cells and NK cells. J Leukoc Biol.65;109-116, 1998
  • Okada, H., Watanabe, T., Niki, M., Takano, H.l, Yanai, N., Tani, K., Hibino, H., Asano, S., Ito, Y., Noda,T., and Satake, M. The AML1(-/-) embryos do not express a set of hematopoiesis-related gene transcripts including that of PU.1. Oncogene 17: 2287-2293, 1998
  • Ahmed, T., Lutton, J.D., Feldman, E., Tani, K., Asano, S. and Abraham, N.G. Gene transfer of alpha interferon into hematopoietic stem cells. Leuk Res 22: 119-124, 1998
  • Yanagie H, Sumimoto H, Nonaka Y, Matsuda S, Hirose I, Hanada S, Sugiyama H, Mikamo S, Takeda Y, Yoshizaki I, Nakazawa K, Tani K, Yamamoto T, Asano S, Eriguchi M, Muto T. Inhibition of human pancreatic cancer growth by the adenovirus-mediated introduction of a novel growth suppressing gene, tob, in vitro. Adv Exp Med Biol 451:91-96, 1998
  • Hibino,H., Tani, K., Ikebuchi,K., Wu, M-S., Sugiyama, H., Nakazaki, Y., Tanabe, T., Takahashi, S., Tojo, A., Suzuki,S., Tanioka,Y., Sugimoto, Y., Nakahata, T., and Asano, S. Common Marmoset as a Target Preclinical Primate for Cytokine and Gene Therapy Studies. Blood 93: 2839-2848, 1999
  • Ohata, J., Matsuoka, M., Yamashita, T., Tojo, A., Tani, K. and Asano, S. CD4/CD8 double-positive adult T cell leukemia with preceding cytomegaloviral gastroenterocolitis. Int J Hematol. 69: 1-5, 1999
  • Koseki, S., Tanabe, T., Tani, K., Asano, S., Shiota, T., Nagai, Y., Shimada, T., Ohkawa, J. and Taira, K. Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III. J Virol 73: 1868-1877, 1999
  • Tsuruta, T., Tani, K., Hoshika, A. and Asano, S. Alkaline phosphatase, defensin gene expression and effect of myeloid cell growth factors in normal and leukemic cells. Leuk Lymphoma 32: 237-247, 1999
  • Tsuruta, T., Tani, K., Hoshika, A. and Asano, S. Myeloperoxidase gene expression and regulation by myeloid cell growth factors in normal and leukemic cells. Leuk Lymphoma
    32: 257-267, 1999
  • Kawai, K., Tani, K., Asano, S. and Akaza, H. Gene-modified immunotherapy for renal cell carcinoma. Contrib Nephrol 128: 75-81, 1999
  • Tani, K., Hibino,H., Sugiyama, H., Wu, M-S., Izawa, K., Tanabe, T., Hase, H., Nakazaki, Y., Ishii, H., Suzuki, S., Tanioka,Y., Sugimoto, Y. and Asano, S. Hematological Aspects of Common Marmoset Monkey Transplanted with autologous MDR1 gene transduced peripheral blood stem cells. Molecular Biology of Hematopoiesis 6: 307-319, 1999
  • Nosaka, T., Onishi, M., Kawashima, T., Yamada, K., Misawa, K., Ariyoshi, K., Towatari, M., Saito, H., Tani, K., Asano, S., Miyajima, A. and Kitamura, K. Identification and characterization of constitutively active Stat 5. Molecular Biology of Hematopoiesis 6: 277-287, 1999

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業績リスト(欧文)1981~1989年

  • Miwa,S.,Fujii,H.,Tani,K.,Takahashi,K.,Takegawa,S.,Fujinami,N.,Sakurai,M.,Kubo,M., Tanimoto,Y.,Kato,T.& Matsumoto,N. Two cases of red cell aldolase deficiency associated with hereditary hemolytic anemia in a Japanese family. Am.J.Hematol. 11:425-437, 1981
  • Fujii,H.,Miwa,S.,Tani,K.,Takegawa,S.,Fujinami,N.,Takahashi,K.,Nakayama,S., Konno,M. & Sato,T.. Glucose 6-phosphate dehydrogenase variants: a unique variant(G6PD Kobe) showed an extremely increased affinity for galactose 6-phosphate and a new variant(G6PD Sapporo) resembling G6PD Pea Ridge. Hum.Genet. 58:405-407, 1981
  • Fujii,H.,Miwa,S.,Tani,K.,Fujinami,N. & Asano, H. Overproduction of structurally normal enzyme in man: hereditary haemolytic anemia with increased red cell adenosine deaminase activity. Br.J.Haematol. 51:427-430, 1982
  • Takahashi,K.,Fujii,H.,Takegawa,S.,Tani,K.,Hirono,A.,Takizawa,T., Kawakatsu,T. & Miwa,S. A new glucose-6-phosphate dehydrogenase variant.(G6PD Nagano) associated with congenital hemolytic anemia. Hum.Genet. 62:368-370, 1982
  • Tani,K.,Fujii,H.,Takegawa,S.,Miwa,S.,Koyama,W.,Kanayama,M.,Imanaka,A., Imanaka,F. & Kuramoto,A. Two cases of phosphofructokinase deficiency associated with congenital hemolytic anemia found in Japan. Am.J.Hematol. 14:165-174, 1983
  • Miwa,S.,Fujii,H.,Tani,K.,Takahashi,K.,Takizawa,T. & Igarashi,T. Red cell adenylate kinase deficiency associated with hereditary nonspherocytic hemolytic anemia:Clinical and biochemical studies. Am.J.Hematol. 14:325-333, 1983
  • Tani, K., Fujii, H., Miwa, S., Imanaka, F., Kuramoto,A. & Ishikawa, H. Phosphofructokinase deficiency associated with congenital nonspherocytic hemolytic anemia and mild myopathy:Biochemical and morphological studies on the muscle. Tohoku J.exp.Med. 141:287-293, 1983
  • Morisaki,T.,Fujii,H.,Takegawa,S.,Tani,K.,Hirono,A.,Takizawa,T.,Takahashi,K.,Shinogi,M., Teshirogi,T. & Miwa,S. G6PD Sendagi:A new glucose-6-phosphate dehydrogenase variant associated with congenital hemolytic anemia. Hum.Genet. 65:214-215, 1983
  • Yoshida,A. & Tani,K. Phosphoglycerate kinase abnormalities: functional, structural and genomic aspects. Biomed.Biochim. Acta 42:s263-267, 1983
  • Tani,K.,Fujii,H. & Miwa,S. Changes in erythrocyte glycolytic intermediates during general anesthesia. Acta Haematol.Jpn. 47:846-852, 1984
  • Tani,K.,Fujii,H.,Asano,S.,Miwa,S. & Ebisawa,I. Imported malaria in Japan: Hematological aspects. Acta Haematol.Jpn. 47:903-908, 1984
  • Singer-Sam,J.,Keith,D.H.,Tani,K.,Simmer,R.L.,Shively,L.,Lindsay,S., Yoshida,A. & Riggs,A.D. Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase. Gene 32:409-417, 1984
  • Tani,K.,Singer-Sam,J.,Manns,M. & Yoshida,A. Molecular cloning and structure of autosomal processed gene for human phosphoglycerate kinase. Gene 35:11-18, 1985
  • Hsu,L.C.,Tani,K.,Fujiyoshi,T.,Kurachi,K. & Yoshida,A. Cloning of cDNA for human aldehyde dehydrogenases 1 and 2. Proc.Natl.Acad.Sci.USA 82: 3771-3775, 1985
  • Tani,K.Takizawa,T. & Yoshida,A. Normal mRNA content in a phosphoglycerate kinase variant with severe enzyme deficiency. Am.J.Hum.Genet. 37:931-937, 1985
  • Yoshida,A.,Ikawa,M.,Hsu,L.C. & Tani,K.. Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. Alcohol 2:103-106, 1985
  • Miwa,S.,Fujii,H.,Tani,K.,Miyamoto,T. & Nishida,Y. Lesch-Nyhan syndrome in Japan. Japan.J.Exp.Med. 56:293-296, 1986
  • Fujii,H.,Kanno,H.,Tani,K. & Miwa,S. Red cell adenosine deaminase overproduction associated with hereditary hemolytic anemia. Academic Press, Orlando, 223-230, 1987
  • Tani, K., Fujii, H., Tsutsumi, H., Sukegawa, J., Toyoshima, K., Yoshida, M. C., Noguchi,T.,Tanaka,T. & Miwa,S. Human liver type pyruvate kinase: cDNA cloning and chromosomal assignment. Biochem Biophys Res Commun. 143:431-438, 1987
  • Morisaki, H., Morisaki, T.,Nakahori, Y., Ogura, H., Kanno, H., Tani, K., Fujii, H., Asano, S. & Miwa, S. Use of Y-chromosome specific probe for detection of engraftment of bone marrow transplantation. Acta Haematol.Jpn. 50: 1254-1257, 1987
  • Morisaki, H., Morisaki, T., Nakahori, Y., Ogura, H., Kanno, H., Tani, K., Kodo, H., Fujii, H., Asano, S. & Miwa, S. Genotypic analysis using a Y-chromosome specific probe following bone marrow transplantation. Am.J.Hematol. 27:30-33, 1988
  • Kanno, H., Fujii, H., Tani, K., Morisaki, T., Hirono, A., Kumakawa, T., Ogura, H., Takahashi, K., Tsutsumi, H. & Miwa, S. A new Glucose-6-phosphate dehydrogenase variant(G6PD Iwate) associated with congenital non-spherocytic hemolytic anemia. Acta Haematol.Jpn.51: 715-719, 1988
  • Kanno, H., Fujii, H., Tani, K., Morisaki, T., Takahashi, K., Horiuchi, N., Kizaki, M., Ogawa, T. & Miwa, S. Elevated erythrocyte adenosine deaminase(ADA) activity in a patient with primary aquired sideroblastic anemia. Am.J.Hematol. 27:216-220, 1988
  • Kanno,H.,Tani,K.,Fujii,H.,Iguchi-Ariga,S.,M.M.,Ariga,H.,Kozaki,T. & Miwa,S. Adenosine deaminase(ADA) overproduction associated with congenital hemolytic anemia. Japan.J.Exp.Med. 58:1-8, 1988
  • Ogura, H., Morisaki, T., Tani, K., Kanno, H., Tsutsumi, H., Takahashi, K., Miyamori, T. Fujii, H.& Miwa, S. A new glucose-6-phosphate dehydrogenase variant(G6PD Tsukui) associated with congenital hemolytic anemia. Hum. Genet. 78:369-371, 1988
  • Tani, K.,Fujii, H.,Nagata, S. & Miwa, S. Human liver type pyruvate kinase: Complete amino acid sequence and the expression in mammalian cells. Proc.Natl. Acad.Sci.USA. 85:1792-1795 1988
  • Morisaki, T.,Tani, K.,Takahashi, K.,Tsutsumi, H.,Horiuchi, N., Ogura,H., Kanno, H.,Fujimura, K.,Nakayama, S.,Watanabe,C.,Takano,N., Miida, T., Mizoguchi,H., Hirai,Y., Uno, H., Fujii, H. & Miwa, S. Ten cases of pyruvat kinase(PK) deficiency found in Japan:enzymatic characterization of the patients' PK. Acta Haematol. Jpn. 51:1080-1085, 1988
  • Morisaki, T.,Horiuchi, N.,Tsutsumi, H.,Ogura,H.,Kanno, H.,Tani,K.,Fujii,H.& Miwa,S. Genetic analysis of adenosine deaminase expression in adult T-cell leukemia. Am.J.Hematol. 28:119-121, 1988
  • Tsutsumi, H.,Tani, K.,Fujii, H.& Miwa, S. Expression of L- and M-type Pyruvate Kinase in Human Tissues. Genomics 2: 86-89, 1988
  • Satoh, H.,Tani, K.,Yoshida, C.M.,Sasaki, M.,Miwa, S. and Fujii, H. The human liver type pyruvate kinase(PKL) gene is on chromosome 1 at band q21. Cytogenet. Cell Genet. 47:132-133, 1988
  • Tani, K.,Tsutsumi, H.,Takahashi, K.,Ogura,H.,Kanno,H.,Hayasaka,K.,Narisawa, K.,Nakahata,T.,Akabane,T.,Morisaki,T.,Fujii,H. and Miwa,S. Two Homozygous Cases of Erythrocyte Pyruvate Kinase(PK) Deficiency in Japan: PK Sendai and PK Shinshu. Am. J. Hematol. 28:186-190, 1988
  • Ogura,H.,Tani,K.,Kanno,H.,Morisaki,T.,Ito,M.,Kubonishi,S.,Miyazaki,K.,Takeuchi,T., Fujii,H. and Miwa,S. Molecular Analysis of Lesch-Nyhan Syndrome Found in Japan. Tohoku J. exp. Med. 155: 1-9, 1988
  • Tani,K., Yoshida, M.C., Satoh, H., Mitamura, K., Noguchi, T., Tanaka, T., Fujii, H. and Miwa, S. Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma. Gene 73:509-516, 1988
  • Tani,K., Fujii, H., Takahashi,K., Kodo, H., Asano, S., Takaku, F. and Miwa, S. Erythrocyte enzyme activities in myelodysplastic syndromes: elevated pyruvate kinase activity. Am. J. Hematol. 30:97-103, 1989
  • Tani, K., Ozawa,K., Ogura, H.,Takahashi, T., Okano, A., Watari, K., Matsudaira,T., Tajika, K., Karasuyama, H., Nagata, S., Asano, S. and Takaku, F. Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor(G-CSF) cDNA into mice as a model of cytokine supplement gene therapy. Blood 74:1274-1280 , 1989
  • Tani, K., Asano, S., Ozawa, K. and Takaku, F. A StuI polymorphism in the human granulocyte colony-stimulating factor gene. Nucl. Acids Res.17:7544, 1989

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英文総説

英文総説(2012~2013年)

  • Nii T, Marumoto T, Tani K. Roles of p53 in various biological aspects of hematopoietic stem cells. J Biomed Biotechnol 2012:903435, 2012 [PubMed]
  • Inoue-Yokoo, T., Tani, K., Sugiyama, D. Mesodermal and hematopoietic differentiation from ES and iPS cells. Stem Cell Rev 9:422-434, 2013 [PubMed]
  • Inoue, H., Tani, K. Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments. Cell Death Differ 21:39-49, 2013 [PubMed]

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邦文総説

邦文総説(2014~2015年)

  • 成澤 慈、井上 博之.マイクロアレイ実験とその応用[研究手法入門:生化学・免疫学的実験法]呼吸,第33巻 第4号,374-380, 2014
  • 高橋 淳、谷 憲三朗.再生医療.臍帯血移植の基礎と臨床(浅野 茂隆、谷口 克監修; 東條 有伸,谷 憲三朗,高橋 聡,幸道 秀樹編集)pp.243-260、医学書院、東京, 2014
  • 谷 憲三朗.再生医療等の安全性の確保等に関する法律について、腫瘍内科 16巻 1号,66-82, 2015

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邦文総説(2010~2013年)

  • 吉村清、岡 正朗、谷憲三朗、遺伝子診療学-遺伝子診断の進歩とゲノム治療の展望-、68:451-457, 2010
  • 谷憲三朗、悪性腫瘍に対する免疫遺伝子・細胞療法の現状と展望、臨床血液 51:296-302, 2010
  • 村橋(伊賀)睦了、土方康基、末廣陽子、田中芳浩、下田真也、丸本朋稔、岡崎利彦、吉田浩二、角田卓也、谷憲三朗、抗腫瘍免疫療法における新戦略-New strategies of immunetherapy targeting malignancy-、臨床血液、51:1654-60, 2010
  • 井上博之、谷憲三朗、サイトカインと癌治療、臨床検査 54:670-676, 2010
  • 谷憲三朗、悪性腫瘍に対する免疫遺伝子・細胞療法の現状と今後の課題、胆と膵、32:107~116,2011
  • Hijikata Y, Murahashi-Iga M, Okazaki T, Tanaka Y, Odaira K, Okano S, Hisano T, Takahashi A, Marumoto T, Inoue H, Tani K. [Development of novel immune therapies for solid tumors: phase I clinical trials in a single institute]. RinshoKetsueki 53(5):487-92, 2012 [PubMed]
  • 横田 洋介、井上 博之、谷 憲三朗. Trends in Hematological Malignancies. LTB4/BLT1 シグナル伝達欠失は免疫機構を増強することで長期的抗腫瘍免疫記憶を促進する 2013年6月30日発行(第5巻 第2号)p16-19 メディカルレビュー社, 2013
  • 井上 博之、高山 浩一、中西 洋一. 癌ワクチン療法(Cancer vaccine therapy)日本臨床 最新肺癌学(基礎と臨床の最新研究動向)71巻 増刊号6 p242-247, 2013
  • 野崎 要、井上 博之、高山 浩一、中西 洋一、谷 憲三朗. 遺伝子治療(Gene therapy)日本臨床 最新肺癌学(基礎と臨床の最新研究動向)71巻 増刊号6 p276-281, 2013

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邦文総説(2006~2009年)

  • 谷憲三朗、トランスレーショナルリサーチとしての免疫遺伝子治療・細胞療法、日本アフェレンシス学会 26:232-237,2007
  • 谷憲三朗、遺伝子療法領域におけるトランスレーショナルリサーチ、Frontiers in Gastroenterology 12:70-80:2007
  • 谷憲三朗、中村 貴史、DDSと細胞療法、最新医学 61:99-105,2006.
  • 谷憲三朗、腎癌に対する遺伝子治療の現状、Biotherapy 20:293-299,2006.
  • 谷憲三朗、トランスレーショナルリサーチとしてのGM-CSF遺伝子治療、泌尿器科 714-720,2006
  • 谷憲三朗、トランスレーショナルリサーチとしての免疫遺伝子治療・細胞療法、日本アフェレンシス学会 26:232-237,2007
  • 谷憲三朗、遺伝子療法領域におけるトランスレーショナルリサーチ、Frontiers in Gastroenterology 12:70-80:2007
  • 谷憲三朗、細胞療法:その現状とトランスレーショナルリサーチからの今後の展望、血液フロンティア 18:17-19 2008
  • 谷憲三朗、遺伝子治療領域における細胞療法の現状、血液フロンティア 18:61-68 2008
  • 谷憲三朗、世界と日本における遺伝子治療の現状、学士鍋142:6-10 2007
  • 谷憲三朗、細胞療法:その現状とトランスレーショナルリサーチからの今後の展望、血液フロンティア 18:17-19 2008
  • 谷憲三朗、遺伝子治療領域における細胞療法の現状、血液フロンティア18:61-68 2008
  • 土方康基、無細胞性のHTLV-1ウイルスは樹上細胞に感染してCD4+T細胞に伝播し形質転換を引き起こす、分子細胞治療 8:80-81 2009
  • 岡崎利彦、染色体遺伝子非組み込み型アデノウイルスベクターによる多能性幹細胞の樹立、分子細胞治療 8:82-83 2009

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邦文総説(2000~2005年)

  • 腎癌に対する免疫遺伝子治療、現代医療、32:1183-1188,2000
  • 腎細胞がんの遺伝子治療、Annual Review 腎臓 2000、205-212, 2000.
  • 癌に対する遺伝子治療、日本外科学会雑誌、101:618-624,2000
  • 免疫遺伝子治療の新展開、分子細胞治療、1:48-53,2000
  • 免疫によるがんの遺伝子治療の現状、最新医学、55:19-24,2000
  • 癌に対する遺伝子治療臨床研究の現状、Jpn J Electroph, 44:103-107,2000
  • GM-CSF遺伝子を用いた免疫遺伝子治療、血液・免疫・腫瘍、5:69-74,2000
  • 遺伝子治療の新たな展開、実験医学、18:140-145,2000
  • 腫瘍免疫遺伝子治療の展開、医学のあゆみ、194:1284-1289,2000
  • 腫瘍免疫遺伝子治療臨床研究の現状、分子細胞療法、2:21-26,2001
  • CMLに対する標的治療法の開発、日本臨床、59:2439-2444,2001
  • 癌の免疫遺伝子治療:腎癌への臨床応用、実験医学、19:90-94,2001
  • 白血病遺伝子治療の新展開、分子がん治療、2:19-24,2001
  • 造血細胞を用いる遺伝子治療、最新医学、56:96-105,2001
  • 化学療法と遺伝子治療、総合臨床、50:210-215,2001
  • 腎癌・前立腺癌などに対するGM-CSF遺伝子治療、カレントテラピー、19:39-43,2001
  • 癌遺伝子治療の新展開、細胞培養工学 27:233-237,2001
  • GM-CSF遺伝子治療の経験から、実験医学、20:852-856,2002
  • マキシザイムとその利用、血液・免疫・腫瘍、7:17-22,2002
  • がんの遺伝子治療の現状、ファルマシア、38:413-416,2002
  • マキシザイムを用いた白血病遺伝子治療法の開発、医学のあゆみ、205:390-397,2002
  • 腎癌に対する免疫遺伝子治療臨床研究の現状、医学のあゆみ、203:307-312,2002
  • 遺伝子治療-現状とその近未来-はじめに、医学のあゆみ、203:279-284,2002.
  • 腎癌の免疫遺伝子治療臨床研究、SRL宝函 26:130-134, 2002
  • 遺伝子治療の方向性?新たな治療ベクターへの挑戦.序文.分子細胞治療 6(2)1-5, 2003
  • 遺伝子治療と細胞療法、最新医学、58:572-583, 2003.
  • GM?CSF免疫遺伝子治療、PharmTechJapan 21:2030-2035,2005.
  • 癌に対するGM?CSF遺伝子導入細胞療法、炎症と免疫 13:723-730,2005
  • 腎癌に対する遺伝子治療臨床研究の現状、日本臨床 63:454-463,2005
  • 腎癌 遺伝子治療学(日本臨床特集)63:526-532,2005
  • 海外における遺伝子治療の現状、遺伝子治療学(日本臨床特集) 63:496-504,2005

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邦文総説(1986~1999年)

  • 遺伝性血液疾患およびホルフィリン症、臨床検査、29:801-808,1985
  • 酵素異常症の分子レベルでの解明、臨床血液、27:1123-1130,1986
  • 異常遺伝子のクローニング、医学のあゆみ 139:498-499,1986
  • 脾臓の機能、肝胆膵 14:865-868,1987
  • ピンビン酸キナーぜ、臨床検査、32:1422-1429,1988
  • ホスホグリセリン酸キナーゼ異常症、蛋白質核酸酵素 33:670-674,1988.
  • 血液腫瘍学における細胞工学・遺伝子診断・遺伝子診断にはどのような諸技術が用いられるか, Medical Practice, 6:47-51,1989
  • CSFの臨床応用、Medical Immunology, 18:483-489,1989
  • 白血病細胞の増殖機構、内科 64:824-830,1989
  • G-CSFレセプターと白血病治療、臨床科学、26:1205-1212,1990
  • ヒト骨髄移植後の造血系再構築のプロセス、日本臨床、48:56-66,1990
  • 白血病または再生不良性貧血に対する骨髄移植後に発症した続発性癌、内科 65: 934-935,1990
  • G-CSFから見た病態解析。造血因子1:42-50,1990
  • 造血因子産生腫瘍、BIOmedica 6:25-29,1990.
  • GVH反応の機序とGVHD予防法、日本臨床 48:1900-1902,1990.
  • C-CSFの抗腫瘍作用、医学のあゆみ、159:855-856,1991
  • 遺伝子操作を加えた線維芽細胞を用いたサイトカイン補充療法の検討、HUMAN CELL, 4:25-31,1991
  • リンパ・血液系に働くサイトカインとその病態解析、蛋白質・核酸・酵素、36:455-466,1991
  • がんの遺伝子治療、BIOmedica, 6:17-24,1991
  • 新しい技術と導入遺伝子の発現調節、今日の移植、4:371-378,1991
  • 遺伝子導入と骨髄移植、医学のあゆみ、164:779-784,1991
  • トランス・レチン酸による急性前骨髄球性白血病の治療、治療学、25:99-100,1991
  • 遺伝子治療、最新医学、46:249-262,1991
  • 慢性骨髄性白血病のインターフェロン療法、臨床医、17:114-119,1991
  • 造血幹細胞への遺伝子導入、医学のあゆみ、156:599-606,1991
  • 遺伝子治療、MEDICO, 23:17-22,1992
  • 遺伝子治療、病態生理, 11:765-774,1992
  • サイトカインの免疫毒性、免疫薬理、10:65-69,1992
  • 慢性骨髄性白血病(CML)のインターフェロン療法、BIOmedica, 7:27-32,1992
  • 癌の遺伝子治療、消化器癌、2:409-418,1992
  • 遺伝子治療の標的細胞、治療学、27:31-36,1993
  • G-CSFからみた病態解析、造血因子、1:42-50,
  • Human Gene Therapy, 感染・炎症・免疫、23:78-86,1993
  • 遺伝子治療、癌と化学療法、20:181-188,1993
  • 遺伝子治療、臨床医、19:129,1993
  • CMLとインターフェロン、血液・腫瘍科、26:341-349,1993
  • 細胞移植と遺伝子治療、medicina, 30:708-711,1993
  • 好中球の抗腫瘍作用、検査と技術、21:79-80,1993
  • 遺伝子導入と骨髄移植、医学のあゆみ、164:779-784,1993
  • CSF刺激による分化因子の遺伝子発現、血液・腫瘍科、27:267-275,1993
  • がんの遺伝子治療、ファルマシア、29:1117-1122,1993
  • 遺伝子治療の標的細胞、治療学、27:31-36,1993
  • 骨髄移植と生着、診断と治療、81:1465-1473,1993
  • がんにおける遺伝子の構造変化、臨床分子医学、1:30-37,1993
  • レトロウイルスベクタ-系を用いた血液幹細胞への遺伝子導入法の開発、細胞科学、5:64-72,1994
  • 血液幹細胞をもちいた遺伝子治療法の開発、BIOclinica, 9:38-44,1994
  • 遺伝子治療の方法論、Medical Immunology, 27:5-9,1994
  • 遺伝子治療、Modern Physician, 14:1533-1540,1994
  • 遺伝子治療法と骨髄移植、日本臨床、特別:824-829,1994
  • 造血幹細胞と遺伝子マーキング、遺伝子治療、実験医学、12:78-81,1994
  • ADA欠損症の遺伝子治療、日本臨床、特別:852-856,1994
  • 白血病の遺伝子治療、CURRENT THERAPY, 12:150-157,1994
  • 血液疾患と遺伝子治療、Biotherapy, 8:1294-1299,1994
  • 遺伝子治療の現状と展望、悪性リンパ腫への応用は可能か?内科、74:346-347,1994
  • レトロウイルスベクタ-を用いた遺伝子導入法、13:445-450,1994
  • ベクタ-等の開発状況、薬事、36:27-32,1994
  • 遺伝子治療の基礎知識、現状、問題点、臨床医、20:72-75,1994
  • インターフェロンによるがん治療、細胞工学、13:37-45,1994
  • 化学療法剤としてのインターフェロンの意義、BIOTHERAPY, 8:1465-1471,1994
  • 増殖因子、サイトカインと幹細胞:細胞移植と遺伝子治療、造血因子、5: 393-400,1994
  • 細胞ターゲッティングや導入遺伝子の発現調節法、造血因子、5:481-486,1994.
  • 補充療法としての遺伝子治療、最新医学、50:259-266,1995
  • 腎がんに対する遺伝子治療、組織培養、21:12-17,1995
  • 遺伝子標識、臨床検査、39:305-308,1995
  • 腎癌に対する遺伝子治療、診断と治療、83:727-732,1995
  • 分子・遺伝子レベルのタ-ゲティング、PRACTICALONCOLOGY, 8:14-15,1995
  • ゾビラックス、デノシン、medicina, 33:501-504,1996
  • 赤血球の糖代謝異常、最新内科学大系8、3:164-175,1996
  • 造血幹細胞への遺伝子導入、医学のあゆみ、176:642-646,1996
  • その他の解糖系の異常、最新内科学大系8、8:124-128,1996
  • レトロビルの適応と投与方法をどうきめるか、medicina, 33:77-81,1996
  • 腎癌の遺伝子治療、Molecular Medicine, 34:432-437, 1997
  • 血液疾患に対する遺伝子治療、最新内科学大系プログレス3、3:79-86,1997
  • 癌治療としての造血幹細胞への遺伝子導入、血液・免疫・腫瘍、2:66-70,1997
  • 癌遺伝子治療の方法と実際:免疫遺伝子治療、血液・免疫・腫瘍、2:253-260,1997
  • 腎癌に対する遺伝子治療法の開発、Surgery Frontier、4:43-48,1997
  • 遺伝子(DNA)治療の臨床展開、治療学、31:87-91,1997
  • 腎癌に対する遺伝子治療、現代医療、29:133-140 ,1997
  • 癌の遺伝子治療:免疫遺伝子治療、34:2171-2176,1997
  • 本邦における遺伝子治療の今後、最新医学、53:89-94,1998
  • 血液悪性腫瘍に対する遺伝子治療、臨床病理、46:797-803,1998
  • 癌に対する遺伝子治療、化学療法の領域、14:107-116,1998.
  • 固形癌に対する遺伝子治療の現状、カレントセラピー、17:107-112,1999
  • 腎癌に対する免疫遺伝子治療、Surgery Frontier, 6:70-74, 1999
  • 固形癌に対する遺伝子治療の現状、CURRENT THERAPY, 17:107-112,1999
  • 腎癌に対する免疫遺伝子治療、日本医師会雑誌, 122:1848, 1999
  • がん遺伝子治療の現状、月刊ナーシング 19:94-97,1999
  • 癌遺伝子治療研究の最前線、実験医学 17:2254-2259,1999

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学会発表

学会発表2014~2015年

  • Takenobu Nii, Tomotoshi Marumoto, Saori Yamaguchi, Jiyuan Liao, Kenzaburo Tani Improved Hematopoietic Differentiation of Primate Embryonic Stem Cells. The 56th American Society of Hematology (ASH) Annual Meeting, San Francisco, CA, USA, 2014
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Yumiko Matsumura, Koichi Takayama, Yoichi Nakanishi and Kenzaburo Tani. The role of plasmacytoid dendritic cells in GM-CSF-based antitumor immunity. The 24th Hot Spring Harbor International Symposium, Fukuoka, 2014
  • Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Misato Kai, Masaki Kuroda, Hiroyuki Shimizu, Yoichi Nakanishi, and Kenzaburo Tani. MicroRNA-targeted coxsackievirus B3 abrogates its pathogenicity retaining oncolytic activity. The 24th Hot Spring Harbor International Symposium, Fukuoka, 2014
  • Hiroyuki Inoue, Yuki Nakano, Beibei Wang, Shohei Miyamoto, Megumi Narusawa, Chika Sakamoto, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Coxsackievirus A11 possesses extensive oncolytic activity against human non-small cell lung cancer cells. The 17th Annual Meeting of American Society of Gene and Cell Therapy. Washington DC, USA, 2014
  • Beibei Wang, Hiroyuki Inoue, Shohei Miyamoto, Yuki Nakano, Chika Sakamoto, Megumi Narusawa, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Coxsackievirus A11 displays remarkable oncolytic activity against oxaliplatin-resistant human colorectal cancer cells. The 17th Annual Meeting of American Society of Gene and Cell Therapy. Washington DC, 2014
  • Miyako Sagara, Misato Kai, Hiroyuki Inoue, Shohei Miyamoto, Yuto Takishima, Kyosuke Kobayashi , Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Coxsackievirus B3 exhibits potent oncolytic activity against both human malignant pleural mesothelioma and triple-negative breast cancer cells. The 17th Annual Meeting of American Society of Gene and Cell Therapy. Washington DC, USA, 2014
  • Chika Sakamoto, Hiroyuki Inoue, Megumi Narusawa, Yumiko Matsumura, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Therapeutic vaccination with irradiated GM-CSF gene-transduced cancer side population cells effectively suppress tumor growth and lung metastasis. The 17th Annual Meeting of American Society of Gene and Cell Therapy. Washington DC, USA, 2014
  • Hiroyuki Inoue, Ayumi Watanabe, Megumi Narusawa, Chika Sakamoto, Takafumi Hiramoto, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Tomoki Todo and Kenzaburo Tani. Therapeutic vaccination with GM-CSF gene-transduced iPS cells induces potent T cells-mediated antitumor immunity. The 105th Annual Meeting of American Association of Cancer Research, San Diego, CA, USA, 2014
  • Yasuki Hijikata, Hiroyuki Inoue, Mutsunori Murahashi, Shinji Okano, Yoshihiro Tanaka, Atsushi Takahashi, Toshihiko Okazaki, Yoichi Nakanishi, Koji Yoshida, Takuya Tsunoda, Yusuke Nakamura, Kenzaburo Tani. A phase I clinical trial of RNF43 peptide-specific immune cell therapy combined with low-dose cyclophosphamide for patients with advanced solid tumors. The 105th Annual Meeting of American Association of Cancer Research, San Diego, CA, USA, 2014
  • Y. Li, K. Kobayashi, M. M. Mona, C. Satomi, K. Tani, A. Takahashi. FEAT inhibits cell death by modifying intracellular localization of apoptotic signaling factors. Gordon Research Conference on Cell Death, West Dover, VT, USA, 2014
  • Y. Li, K. Kobayashi, M.M. Mona, C. Satomi, K. Tani, A. Takahashi. Biochemical and intracellular functions of antiapoptotic FEAT protein. Cell Symposia: Hallmarks of Cancer: Asia, Beijing, China, 2014
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi and Kenzaburo Tani. Plasmacytoid dendritic cells play an essential role in induction of GM-CSF-based antitumor immunity. 第76回日本血液学会学術集会,大阪, 2014
  • Chika Sakamoto, Hiroyuki Inoue, Megumi Narusawa, Yumiko Matsumura, Kazunari Yamada, Takafumi Hiramoto, Atsushi Takahashi, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Therapeutic tumor vaccination with GM-CSF gene-transduced cancer stem cells provokes potent antitumor immunity. 第76回日本血液学会学術集会,大阪, 2014
  • Takenobu Nii, Tomotoshi Marumoto, Saori Yamaguchi, Jiyuan Liao, Kazunari Yamada, Yasuki Hijikata, Toshiyuki Tsuruta and Kenzaburo Tani. Improved hematopoietic differentiation of primate ESCs by inhibition of PI3K-AKT pathway. 第76回日本血液学会学術集会, 大阪, 2014
  • Hiroyuki Inoue, Yuki Nakano, Beibei Wang, Megumi Narusawa, Shohei Miyamoto, Chika Sakamoto, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Coxsackievirus A11 exhibits ICAM-1-mediated oncolysis against human non-small cell lung cancer cells. 第73回日本癌学会学術総会,横浜, 2014
  • Yasuki Hijikata, Toshihiko Okazaki, Kazunari Yamada, Koji Yoshida, Hiroyuki Inoue, Sonoko Ishihara, Kenzaburo Tani. A Phase I Clinical Trial of Immune Cell Therapy Combined with Cyclophosphamide for Patients with Advanced Solid Tumors. 第73回日本癌学会学術総会,横浜, 2014
  • Beibei Wang, Hiroyuki Inoue, Shohei Miyamoto, Yuki Nakano, Chika Sakamoto, Megumi Narusawa, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Coxsackievirus A11 is a promising oncolytic virus agent against oxaliplatin-resistant human colorectal cancer cells. 第73回日本癌学会学術総会,横浜, 2014
  • Miyako Sagara, Misato Kai, Shohei Miyamoto, Hiroyuki Inoue, Yuto Takishima, Kyosuke Kobayashi, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Coxsackievirus B3 confers robust oncolytic activity in malignant pleural mesothelioma and triple-negative breast cancer. 第73回日本癌学会学術総会,横浜, 2014
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Yumiko Matsumura, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi and Kenzaburo Tani. A role of plasmacytoid DCs in GM-CSF-induced antitumor immunity. 第6回血液疾患免疫療法研究会学術集会,京都, 2014
  • Hiroyuki Inoue, Yuki Nakano, Beibei Wang, Shohei Miyamoto, Megumi Narusawa, Chika Sakamoto, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Coxsackievirus A11 displays remarkable oncolytic activity against human non-small cell lung cancer cells. 第20回日本遺伝子治療学会学術集会,東京, 2014
  • Chika Sakamoto, Hiroyuki Inoue, Megumi Narusawa, Yumiko Matsumura, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Therapeutic vaccination with irradiated GM-CSF gene transduced cancer stem cells induces potent antitumor immunity in mice. 第20回日本遺伝子治療学会学術集会,東京, 2014
  • Beibei Wang, Hiroyuki Inoue, Shohei Miyamoto, Yuki Nakano, Chika Sakamoto, Megumi Narusawa, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Oncolytic virotherapy for oxaliplatin-resistant colorectal cancer cells using coxsackievirus A11. 第20回日本遺伝子治療学会学術集会,東京, 2014
  • Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Misato Kai, Yuto Takishima, Kyosuke Kobayashi, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Coxsackievirus B3 displays remarkable oncolytic activity against both malignant pleural mesothelioma and triple-negative breast cancer cells. 第20回日本遺伝子治療学会学術集会,東京, 2014
  • Takenobu Nii, Tomotoshi Marumoto, Saori Yamaguchi, Hirotaka Kawano, Jiyuan Liao, Kenzaburo Tani. Improved hematopoietic differentiation of common marmoset embryonic stem cell. 第12回幹細胞シンポジウム, 福岡, 2014
  • Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Koichi Takayama, Takafumi Hiramoto, Yoichi Nakanishi, and Kenzaburo Tani. Therapeutic vaccination using irradiated iPS cells induces potent antitumor immunity against poorly immunogenic lung tumors.第54回日本呼吸器学会学術講演会,大阪, 2014
  • Yasuki Hijikata, Toshihiko Okazaki, Yoshihiro Tanaka, Kazunari Yamada and Kenzaburo Tani. A phase 1 clinical trial of RNF43 peptide-specific immune cell therapy combined with low dose cyclophosphamide for patients of advanced solid tumors. 第6回血液疾患免疫療法研究会学術集会,京都, 2014
  • 山口沙織,丸本朋稔,二井偉暢,河野紘隆,寥紀元,永井陽子,岡田美智代,高橋淳,井上博之,佐々木えりか,藤井浩,岡野慎士,海老瀬速雄,佐藤哲也,須山幹太,岡野栄之,三浦由恵,谷憲三朗.初期化因子搭載レンチウイルスベクターにより誘導された未分化胚細胞腫様コモンマーモセット腫瘍の特性.第4回日本マーモセット研究会大会,愛知, 2015
  • Takenobu Nii, Tomotoshi Marumoto, Saori Yamaguchi, Hirotaka Kawano, Jiyuan Liao, Erika Sasaki and Kenzaburo Tani. Transient inhibition of PI3K-AKT pathway promotes hematopoietic differentiation in common marmoset embryonic stem cells.第4回日本マーモセット研究会, 愛知, 2015
  • Y. Li, K. Kobayashi, C. Satomi, K. Tani, A. Takahashi: Biochemical and intracellular function of FEAT protein. 第74回日本癌学会学術総会, 名古屋, 2015
  • C. Satomi, M.M. Mona, K. Kobayashi, Y. Li, K. Tani, A. Takahashi: Regulation of human FEAT gene promoter. 第74回日本癌学会学術総会, 名古屋, 2015

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学会発表2012~2013年

  • Hiroyuki Inoue, Yasuki Hijikata, Keisuke Yasunari, Akira Sakamoto, Shohei Miyamoto, Kaname Nosaki, Yumiko Matsumura, Koichi Takayama, Yoichi Nakanishi, and Kenzaburo Tani. Genetically engineered oncolytic Edmonston strain of measles virus harboring the wild-type N, P, L Genes (MV-NPL) effectively target lung cancer stem cells. American Association of Cancer Research, 103th Annual Meeting, Chicago, 2012
  • Shohei Miyamoto, Hiroyuki Inoue, Beibei Wang, Keisuke Yasunari, Takafumi Nakamura, Meiko Yamada, Yasuo Urata, Tomotoshi Marumoto, Atsushi Takahashi, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu and Kenzaburo Tani. Coxsackievirus B3 is an immunostimulatory oncolytic virus active against lung adenocarcinoma. American Association of Cancer Research, 103th Annual Meeting, Chicago, 2012
  • Keisuke Yasunari, Hiroyuki Inoue, Shohei Miyamoto, Beibei Wang, Yasuo Urata, Koichi Takayama, Yoichi Nakanishi and Kenzaburo Tani. Oncolytic Echovirus 4 as a potent virotherapy agent against human esophageal squamous cell carcinoma. American Society of Gene and Cell Therapy, 15th Annual Meeting, Philadelphia, 2012
  • Hiroyuki Inoue, Keisuke Yasunari, Akira Sakamoto, Shohei Miyamoto, Kaname Nosaki, Yumiko Matsumura, Takafumi Nakamura, Koichi Takayama, Yoichi Nakanishi, and Kenzaburo Tani. Genetically engineered Measles virus Edmonston strain expressing the wild-type N, P, L Genes (MV-NPL) is a promising oncolytic virotherapy agent against lung cancer stem cells. American Society of Gene and Cell Therapy, 15th Annual Meeting, Philadelphia, 2012
  • Hiroyuki Inoue, Keisuke Yasunari, Yumiko Matsumura, Shohei Miyamoto, Kaname Nosaki, Akira Sakamoto, Koichi Takayama, Yoichi Nakanishi, and Kenzaburo Tani. Genetically engineered oncolytic measles virus lyses non-small cell lung cancer stem cells in vitro and in vivo. Asian Pacific Lung Cancer Conference, 5th Annual Meeting, Fukuoka, 2012
  • Hiroyuki Inoue, Keisuke Yasunari, Yumiko Matsumura, Shohei Miyamoto, Akira Sakamoto, Kaname Nosaki, Koichi Takayama, Yoichi Nakanishi, and Kenzaburo Tani. Genetically engineered oncolytic measles virus effectively targets and kills non-small cell lung cancer stem cells. Asian Pacific Society of Respirology, 17th Annual Meeting, Hong Kong, 2012
  • Saori Yamaguchi, Tomotoshi Marumoto,, Takenobu Nii, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiko Okada, Atsushi Takahashi, Hiroyuki Inoue, Erika Sasaki, Shinji Okano, Yoshie Miura, Kenzaburo Tani. Chracterization of dysgerminoma like tumors arose in the process of generating common marmoset induced pluripotent stem cells. International Society for Stem Cell Research (ISSCR), 10th Annual Meeting, Yokohama, 2012
  • Takenobu Nii, Tomotoshi Marumoto, Hirotaka Kawano, Saori Yamaguchi, Yoko Nagai, Yoshie Miura, Jiyuan Liao, Michiyo Okada, Kenzaburo Tani. Efficient hematopoietic differentiation of common marmoset embryonic stem cells by the inhibition of PI3K-AKT pathway. International Society for Stem Cell Research (ISSCR), 10th Annual Meeting, Yokohama, 2012
  • Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Naoki Takeda, Chika Sakamoto, Hirotaka Kawano, Takenobu Nii, Yoko Nagai, Michiyo Okada, Yoshie Miura, PhD1, Shinya Shimoda, Hiroyuki Inoue, Atsushi Takahashi, Masato Tanaka, Kaori Nagatoshi, Ken-ichi Yamamura, Kohichi Kawahara, Akira Suzuki, and Kenzaburo Tani. Efficient generation of induced pluripotent stem cells by the use of Pten inhibitor. International Society for Stem Cell Research (ISSCR), 10th Annual Meeting, Yokohama, 2012
  • Kobayashi K, Li Y, Kawahara K, Suzuki A, Tani K, Takahashi A. Characterization of FEAT functions in vivo. Gordon Research Conference on Cell Death, Lucca (Barga), Italy, 2012
  • Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Yoshie Miura, Hiroyuki Inoue, Masato Tanaka, Kaori Nagatoshi, Kohichi Kawahara, Akira Suzuki, Kenzaburo Tani, Efficient generation of induced pluripotent stem cells by the inhibition of PTEN tumor suppressor. The 21st Hot Spring Harbor Symposium jointly with 9th Global COE International Symposium. Cell Migration in Biology and Medicine, Fukuoka, 2012
  • Murahashi M, Hijikata Y, Tanaka Y, Inoue H, Marumoto T, Nakanishi Y, Yoshida K, Tsunoda Nakamura, Y, Tani K. Phase I clinical trial of cancer vaccine combined with chemotherapy targeting both tumor antigen and immune tolerance against advanced solid tumors. 37th ESMO Congress, Vienna, Austria, 2012
  • Yosuke Yokota, Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Koichi Takayama, Yoichi Nakanishi ,Takehiko Yokomizo and Kenzaburo Tani. Absence of LTB4/BLT1 axis promotes generation of long-lasting antitumor memory responses induced by administration of GM-CSF gene-transduced tumor cells, in a CD4+ T cell-dependent manner. American Society of Hematology, 54th Annual Meeting, San Diego, 2012
  • Jiyuan Liao, Tomotoshi Marumoto, Shinji Okano, Saori Yamaguchi, Takenobu Nii, Hirotaka Kawano, Yoko Nagai, Chika Sakamoto, Michiyo Okada, Yoshie Miura, Hiroyuki Inoue, Masato Tanaka, Kaori Nagatoshi, Kohichi Kawahara, Akira Suzuki and Kenzaburo Tani, Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells. American Society of Hematology, 54th Annual Meeting, San Diego, 2012
  • Hiroyuki Inoue, Shohei Miyamoto, Takafumi Nakamura, Meiko Yamada, Yasuo Urata, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu and Kenzaburo Tani. Coxsackievirus B3 (CVB3) as a Novel Oncolytic Virotherapy Agent against Non Small Cell Lung Cancer. 第52回日本肺癌学会総会, 大阪, 2012
  • Hiroyuki Inoue, Shohei Miyamoto, Meiko Yamada, Takafumi Nakamura, Nosaki Kaname, Urata Yasuo, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Coxsackievirus B3 is an Oncolytic Virus Active Against Non-Small Cell Lung Cancer. 第52回日本呼吸器学会学術講演会, 神戸, 2012
  • Hiroyuki Inoue, Akira Sakamoto, Keisuke Yasunari, Shohei Miyamoto, Yumiko Matsumura, Kaname Nosaki, Koichi Takayama, Yoichi Nakanishi, and Kenzaburo Tani. Novel engineered oncolytic Edmonston strain of measles virus elicits remarkable oncolytic activity against non-small cell lung cancer stem cells. 第18回日本遺伝子治療学会, 熊本, 2012
  • Shohei Miyamoto, Hiroyuki Inoue, Beibei Wang, Chika Sakamoto, Megumi Narusawa, Takafumi Nakamura, Meiko Yamada, Yasuo Urata, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu and Kenzaburo Tani. Coxsackievirus B3 is an immunostimulatoryoncolytic virus active against lung adenocarcinoma. 第18回日本遺伝子治療学会, 熊本, 2012
  • Saori Yamaguchi, Tomotoshi Marumoto, Takenobu Nii, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Atsushi Takahashi, Hiroyuki Inoue, Erika Sasaki, Shinji Okano, Yoshie Miura and Kenzaburo Tani. Characterization of common marmoset dysgerminoma-like tumors generated by the transduction of reprogramming factors. 第18回日本遺伝子治療学会, 熊本, 2012
  • Takenobu Nii, Tomotoshi Marumoto, Hirotaka Kawano, Saori Yamaguchi, Yoko Nagai, Yoshie Miura, Jiyuan Liao, Michiyo Okada, Kenzaburo Tani. Efficient hematopoietic differentiation of common marmoset embryonic stem cells by the inhibition of PI3K-AKT pathway. 第18回日本遺伝子治療学会, 熊本, 2012
  • Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Naoki Takeda, Chika Sakamoto, Hirotaka Kawano, Takenobu Nii, Yoko Nagai, Michiyo Okada, Yoshie Miura, Shinya Shimoda, Hiroyuki Inoue, Atsushi Takahashi, Masato Tanaka, Kaori Nagatoshi, Ken-ichi Yamamura, Kohichi Kawahara, Akira Suzuki and Kenzaburo Tani. Highly efficient generation of induced pluripotent stem cells by the inhibition of PTEN tumor suppressor. 第18回日本遺伝子治療学会, 熊本, 2012
  • Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Hirotaka Kawano, Takenobu Nii, Yoko Nagai, Chika Sakamoto, Michiyo Okada, Yoshie Miura, Hiroyuki Inoue, Masato Tanaka, Kaori Nagatoshi, Kohichi Kawahara, Akira Suzuki and Kenzaburo Tani. Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells. 九州大学グローバルCOE・生体防御医学研究所 国際シンポジウム若手発表会, 福岡, 2012
  • Hiroyuki Inoue, Shohei Miyamoto, Beibei Wang, Keisuke Yasunari, Meiko Yamada, Yasuo Urata, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu and Kenzaburo Tani. 非小細胞肺癌に対するコクサッキーウイルスB3を用いた新規腫瘍溶解性ウイルス療法, 第28回日本DDS学会学術集会, 札幌, 2012
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Yosuke Yokota, Ayumi Watanabe, Shohei Miyamoto, Koichi Takayama, Makoto Inoue, Mamoru Hasegawa, Yoichi Nakanishi and Kenzaburo Tani. TLR7 ligand Imiquimod enhances GM-CSF-induced immunological antitumor effect. 第4回造血器腫瘍免疫療法研究会学術集会, 金沢, 2012
  • 土方 康基, 岡崎 利彦, 田中 芳浩, 小林 慎一, 村橋 睦了, 山田 一成, 丸本 朋稔, 井上 博之, 谷 憲三朗, A phase I study of adoptive immunotherapy using autologous dendritic cell pulsed with a RNF43 peptide in patients with advanced solid tumors. 第4回造血器腫瘍免疫療法研究会学術集会, 金沢, 2012
  • 村橋 睦了, 土方 康基, 田中 芳浩, 岸本 淳司, 井上 博之, 丸本 朋稔, 高橋 淳, 岡崎 利彦, 平川 雅和, 岡野 慎士, 谷 憲三朗, Multipeptide immune responses to cancer vaccine after cyclophosphamide correlated with longer survival of the patients with advanced solid tumors, 第4回造血器腫瘍免疫療法研究会学術集会, 金沢, 2012
  • 宮原 裕, 村橋睦了, 山田一成, 土方康基, 井上博之, 丸本朋稔, 松田めぐみ,谷 憲三朗, 塩化ナトリウム内服で改善した中枢性塩類喪失症候群(Cerebral Salt Wasting Syndrome: CSWS)の1例, 第300回日本内科学会九州地方会, 福岡, 2012
  • Ayumi Wanatabe, Hiroyuki Inoue, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Makoto Inoue, Keisuke Okita, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Shinya Yamanaka and Kenzaburo Tani. Novel cancer immunotherapy using induced pluripotent stem cells genetically engineered to produce GM-CSF. 第71回日本癌学会学術総会, 札幌, 2012
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Ayumi Watanabe, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi and Kenzaburo Tani. Plasmacytoid DCs are involved in an antitumor immunity induced by GM-CSF gene-transduced tumor cells. 第71回日本癌学会学術総会, 札幌, 2012
  • Hiroyuki Inoue, Keisuke Yasunari, Shohei Miyamoto, Yumiko Matsumura, Kaname Nosaki, Akira Sakamoto, Koichi Takayama, Yoichi Nakanishi and Kenzaburo Tani. Novel engineered oncolytic measles virus shows oncolytic acticity against non-small cell lung cancer stem cells. 第71回日本癌学会学術総会, 札幌, 2012
  • Shohei Miyamoto, Hiroyuki Inoue, Beibei Wang, Keisuke Yasunari, Chika Sakamoto, Megumi Narusawa, Takafumi Nakamura, Meiko Yamada ,Yasuo Urata, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu and Kenzaburo Tani. Immunostimulatory coxsackievirus B3 as a potent oncolytic agent against non-small cell lung carcinoma. 第71回日本癌学会学術総会, 札幌, 2012
  • Kobayashi K, Kawahara K, Suzuki A, Tani K, Takahashi A. Characterization of FEAT functions in vivo. 第71回日本癌学会学術総会, 札幌, 2012
  • 土方康基, 岡崎利彦, 田中芳浩, 大平公亮, 小林慎一, 村橋睦了, 高橋淳, 丸本朋稔, 井上博之, 吉田浩二, 角田卓也, 谷憲三朗, 進行固形腫瘍患者に対する化学療法併用新規免疫細胞療法臨床研究,第50回日本癌治療学会学術集会, 横浜, 2012
  • Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. A novel cancer cell vaccine using induced pluripotent stem cells genetically engineered to produce GM-CSF elicits substantial antitumor immunity in a syngeneic mouse model. The 16th Annual Meeting of American Society of Gene and Cell Therapy. Salt Lake City, UT, May 15-18, 2013
  • Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Dual microRNA-regulated oncolytic coxsackievirus B3 infection displays antitumor activity with attenuated pathogenicity in mice. The 16th Annual Meeting of American Society of Gene and Cell Therapy. Salt Lake City, UT, May 15-18, 2013
  • Takafumi Hiramoto, Yasuhiro Ebihara Yoko Mizoguchi, Kazuhiro Nakamura, Kiyoshi Yamaguchi, Kazuko Ueno, Shinji Mochizuki, Naoki Nariai, Shohei Yamamoto, Masao Nagasaki, Yoichi Furukawa, Kenzaburo Tani, Hiromitsu Nakauchi, Masao Kobayashi, and Koichiro Tsuji. The activation of the Wnt3a/β-catenin pathway induced maturation of impaired neutrophils as well as the endoplasmic reticulum stress in induced pluripotent stem cell derived from a Severe Congenital Neutropenia patient with ELANE mutation. The 16th Annual Meeting of American Society of Gene and Cell Therapy. Salt Lake City, UT, May 15-18, 2013
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Tomoko Inoue, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Combination use of TLR7 ligand with GM-CSF gene-transduced tumor vaccines provides substantial antitumor immunity against poorly immunogenic mouse lung cancer cells. The 16th Annual Meeting of American Society of Gene and Cell Therapy. Salt Lake City, UT, May 15-18, 2013
  • Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Chika Sakamoto, Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu Yoichi Nakanishi and Kenzaburo Tani. CVB3 infection elicits potent oncolytic activity against lung cancer stem cells. The 16th Annual Meeting of American Society of Gene and Cell Therapy. Salt Lake City, UT, May 15-18, 2013
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Tomoko Inoue, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Kenzaburo Tani. Gene expression profiling identifies plasmacytoid dendritic cells as positive regulators in GM-CSF-induced antitumor immunity. The 4th Japanese Society of Hematology International Symposium 2013, Matsuyama, Japan, May 24-25, 2013
  • Takenobu Nii, Tomotoshi Marumoto, Saori Yamaguchi, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Yoshie Miura, Kenzaburo Tani: Efficient hematopoietic differentiation of common marmoset embryonic stem cells by the inhibition of their self-renewal pathway. International Society for Stem Cell Research (ISSCR), Boston, MA, June 12-15, 2013
  • Chika Sakamoto, Hiroyuki Inoue, Megumi Narusawa, Shohei Miyamoto, and Kenzaburo Tani. Therapeutic vaccine with GM-CSF gene-transduced cancer stem cells inhibits tumor growth and metastasis of breast cancer. The 23rd Hot Spring Harbor International Symposium, Recent Advances in Stem Cell Biology 2013. Fukuoka, Japan, November 4-6, 2013
  • Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani. MicroRNA-regulated coxsackievirus B3 abrogates its pathogenicity retaining oncolytic activity. The 23rd Hot Spring Harbor International Symposium, Recent Advances in Stem Cell Biology 2013. Fukuoka, Japan, November 4-6, 2013
  • Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani. MicroRNA-targeted coxsackievirus B3 infection markedly reduces its toxicity without losing its original oncolytic activity. Therapeutics Discovery Symposium Asia Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013 Meeting On ‘RNA Regulation to Delivery, Programming to Pluripotency & Therapeutics’. Tokyo, Japan, November 25-26, 2013
  • Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Takafumi Hiramoto, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Vaccination with irradiated induced pluripotent stem cells genetically engineered to produce GM-CSF confers potent T cells-mediated antitumor immunity. The 55th ASH Annual Meeting and Exposition. New Orleans, LA, December 7-10, 2013
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Yumiko Matsumura, Atsushi Takahashi, Ayumi Watanabe, Tomoko Inoue, Shohei Miyamoto, Koichi Takayama, Makoto Inoue, Mamoru Hasegawa, Yoichi Nakanishi and Kenzaburo Tani. TLR7 ligand potentiates GM-CSF-initiated antitumor immunity through activation of plasmacytoid dendritic cells. The 55th ASH Annual Meeting and Exposition. New Orleans, LA, December 7-10, 2013
  • Hirotaka Kawano, Tomotoshi Marumoto, Takafumi Hiramoto, Michiyo Okada, Tomoko Inoue, Takenobu Nii, Jiyuan Liao, Saori Yamaguchi, Hiroyuki Inoue, Erika Sasaki, Yoshie Miura, Kenzaburo Tani. Induced hematopoietic differentiation of Common Marmoset Embryonic Stem Cells by LYL1 can give rise to Hematopoietic Stem Cells having the Enhanced Bone Marrow Reconstitution capability. The 55th ASH Annual Meeting and Exposition. New Orleans, LA, December 7-10, 2013
  • Hiroyuki Inoue, Keisuke Yasunari, Yumiko Matsumura, Kaname Nosaki, Shohei Miyamoto, Koichi Takayama, Yoichi Nakanishi, and Kenzaburo Tani. 肺癌幹細胞を標的とした新規遺伝子改変麻疹腫瘍溶解性ウイルス療法. 第53回日本呼吸器学会学術講演会, 東京, 2013
  • Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Vaccination with irradiated induced pluripotent stem cells genetically engineered to secrete GM-CSF provides substantial antitumor immunity in immunocompetent syngeneic mouse models. 第19回日本遺伝子治療学会, 岡山, 2013
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Tomoko Inoue, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Kenzaburo Tani. Plasmacytoid dendritic cells play an essential role in GM-CSF-induced antitumor immunity. 第19回日本遺伝子治療学会, 岡山, 2013
  • Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Chika Sakamoto, Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. Differential susceptibility of cancer stem cells and cancer cells undergoing epithelial-mesenchymal transition to oncolysis by CVB3 infection. 第19回日本遺伝子治療学会, 岡山, 2013
  • Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, and Kenzaburo Tani. Infection with dual microRNA-targeted coxsackievirus B3 abrogates its pathogenicity retaining oncolytic activity. 第19回日本遺伝子治療学会, 岡山, 2013
  • Hiroyuki Inoue, Keisuke Yasunari, Beibei Wang, Shohei Miyamoto, Koichi Takayama, Yoichi Nakanishi and Kenzaburo Tani. Infection with Echovirus?4 elicits potent oncolytic activity against cisplatin-resistant esophageal carcinoma. 第72回日本癌学会学術総会, 横浜, 2013
  • Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Chika Sakamoto, Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. CVB3 infection displays different oncolytic activities against cancer stem cells and cancer cells undergoing EMT. 第72回日本癌学会学術総会, 横浜, 2013
  • Chika Sakamoto, Hiroyuki Inoue, Megumi Narusawa, Shohei Miyamoto, Tomotoshi Marumoto, Atsushi Takahashi, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Therapeutic vaccine with GM-CSF gene-transduced cancer stem cells inhibits tumor growth and metastasis of breast cancer. 第72回日本癌学会学術総会, 横浜, 2013
  • Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi and Kenzaburo Tani. MicroRNA-targeted coxsackievirus B3 infection markedly reduces its pathogenicity retaining oncolytic activity. 第72回日本癌学会学術総会, 横浜, 2013
  • Toshihisa Tsuruta, Yasuo Aihara, Kazunari Yamada, Hiroyuki Inoue, Yasuki Hijikata, Tomotoshi Marumoto, Yoshikazu Okada, Kenzaburo Tani. Akt gene activation via VEGFR as a prognostic factor of pediatric low-grade glioma. 第72回日本癌学会学術総会, 横浜, 2013
  • Yasuki Hijikata, Toshihiko Okazaki, Tomotoshi Marumoto, Hiroyuki Inoue, Toshihisa Tsuruta, Kazunari Yamada, Mutsunori Murahashi, Takuya Tsunoda, Kenzaburo Tani. A phase I clinical study of a novel immunotherapy combined chemotherapy in patients with advanced solid tumors. 第72回日本癌学会学術総会, 横浜, 2013
  • Kyosuke Kobayashi, Koichi Kawahara, Akira Suzuki, Kenzaburo Tani, Atsushi Takahashi. Functions of FEAT tumor promoter in ES cells. 第72回日本癌学会学術総会, 横浜, 2013
  • Yan Li, Kyosuke Kobayashi, Kenzaburo Tani, Atsushi Takahashi. Identification of proteins that interact with FEAT tumor promoter. 第72回日本癌学会学術総会, 横浜, 2013
  • Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Vaccination with irradiated induced pluripotent stem cells elicits substantial antitumor immunity. 第75回日本血液学会学術集会, 札幌, 2013
  • Megumi Narusawa, Hiroyuki Inoue, Chika Sakamoto, Tomoko Inoue, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Kenzaburo Tani. TLR7 ligand overcomes therapeutic resistance to GM-CSF-gene transduced tumor vaccination. 第75回日本血液学会学術集会, 札幌, 2013
  • Takenobu Nii, Tomotoshi Marumoto, Saori Yamaguchi, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Yoshie Miura, Kenzaburo Tani: Efficient hematopoietic differentiation of common marmoset ES cells by inhibition of self-renewal. 第75回日本血液学会学術集会, 札幌, 2013
  • Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Takafumi Hiramoto, Yoichi Nakanishi, and Kenzaburo Tani. Therapeutic iPS cell vaccination induces effective antitumor immunity in a syngeneic mouse model. 第54回日本肺癌学会総会, 東京, 2013
  • Saori Yamaguchi, Tomotoshi Marumoto, Takenobu Nii, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Atsushi Takahashi, Hiroyuki Inoue, Erika Sasaki, Hiroshi Fujii, Shinji Okano, Yoshie Miura and Kenzaburo Tani. Characterization of dysgerminoma like tumors arisen in the process of generating common marmoset induced pluripotent stem cells. 第3回日本マーモセット研究会, 福岡, 2013
  • Hirotaka Kawano, Tomotoshi Marumoto, Takafumi Hiramoto, Michiyo Okada, Takenobu Nii, Jiyuan Liao, Saori Yamaguchi, Hiroyuki Inoue, Erika Sasaki, Yoshie Kametani, Yoshie Miura, Kenzaburo Tani. LYL1, a basic helix-loop-helix transcription factor, induces hematopoietic stem cell from common marmoset embryonic stem cell. 第3回日本マーモセット研究会, 福岡, 2013
  • Takenobu Nii, Tomotoshi Marumoto, Saori Yamaguchi, Hirotaka Kawano, Jiyuan Liao, Erika Sasaki and Kenzaburo Tani. Transient inhibition of PI3K-AKT pathway promotes hematopoietic differentiation in common marmoset embryonic stem cells. 第3回日本マーモセット研究会, 福岡, 2013
  • Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Takafumi Hiramoto, Yoichi Nakanishi, and Kenzaburo Tani. A novel cell vaccination using irradiated induced pluripotent stem cells induces potent T cells-mediated antitumor immunity. 第11回日本免疫治療学研究会学術集会, 東京, 2013
  • Chika Sakamoto, Hiroyuki Inoue, Megumi Narusawa, Yumiko Matsumura, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Therapeutic vaccination with GM-CSF gene-transduced breast cancer stem cells effectively suppress tumor growth and lung metastasis. 第11回日本免疫治療学研究会学術集会, 東京, 2013
  • 土方 康基. 当科における難治性悪性腫瘍に対する免疫療法臨床試験の現状.第11回日本免疫治療学会研究会学術集会,東京, 2013
  • Yasuki Hijikata, Toshihiko Okazaki, Yoshihiko Tanaka, Shinichi Kobayashi, Kazunari Yamada, Tomotoshi Marumoto, and Kenzaburo Tani. A phase Ⅰstudy of adoptive immunotherapy using autologous dendritic cell pulsed with a RNF43 peptide in patients with advanced solid tumors. 第5回造血器腫瘍免疫療法研究会,名古屋, 2013
  • Yasuki Hijikata, Toshihiko Okazaki, Yoshihiko Tanaka, Shinichi Tanaka, Kazunari Yamada, and Kenzaburo Tani. A phase I clinical study of a novel immunotherapy for advanced solid tumors. 第51回日本癌治療学会学術集会,横浜, 2013
  • 井上 博之, 王 倍倍, 中野友紀, 安成 啓佑, 宮本 将平, 高山 浩一, 中西 洋一, 谷 憲三朗. ヒトエンテロウイルスを用いた新規腫瘍溶解性ウイルス療法. 文部科学省[橋渡し研究加速ネットワークプログラム]TR推進合同フォーラム -アカデミアの活力と実力を社会へ-, 福岡, 2013
  • 小林 恭介, 李 妍, 河原 康一, 鈴木 聡, 谷 憲三朗, 高橋 淳.腫瘍促進タンパクFEATを用いた癌早期発見への応用. 文部科学省[橋渡し研究加速ネットワークプログラム]TR推進合同フォーラム -アカデミアの活力と実力を社会へ-, 福岡, 2013

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学会発表2010~2011年

  • Tomoko Inoue, Daisuke Sugiyama, Ryo Kurita, Tatsuo Oikawa, Kasem Kulkeaw, Hirotaka Kawano, Yoshie Miura, Michiyo Okada, Youko Suehiro, Atsushi Takahashi, Tomotoshi Marumoto, Hiroyuki Inoue, Norio Komatsu, Kenzaburo Tani: APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cells in mice and humans. American Society of Gene and Cell Therapy, 13th Annual Meeting, Washington, DC, 2010
  • Shohei Miyamoto, Hiroyuki Inoue, Meiko Yamada, Xin Meng, Takafumi Nakamura, Yasuo Urata, Hiroyuki Shimizu, Kenzaburo Tani: A novel coxsackievirus B shows remarkable oncolytic capacity against lung cancer. American Society of Gene and Cell Therapy, 13th Annual Meeting, Washington, DC, 2010
  • Yamaguchi S, Marumoto T, Kawano H, Shimoda S, Miura Y, Miyoshi H, Sasaki E, Takahashi A, Tani K: Establishment of iPS cells derived from the New World monkey of common marmoset. American Society of Gene and Cell Therapy, 13th Annual Meeting, Washington, DC, 2010
  • Marumoto T,Development of a novel mouse glioma model using lentiviral vectors. The Japan Society of Neuro-oncology, 28th Annual meeting, Hoshino Award Lecture, Karuizawa, 2011
  • Hiroyuki Inoue, Shohei Miyamoto, Meiko Yamada, Takafumi Nakamura, Yasuo Urata, Hiroyuki Shimizu, Koichi Takayama , Yoichi Nakanishi , Kenzaburo Tani:Coxsackievirus B possesses remarkable oncolytic activity against human lung cancer without lethal side effects.APSR Travel Grant in the 15th Congress of the Asian Pacific Society of Respirology , Manila, 2010
  • Hiroyuki Inoue, Shohei Miyamoto, Meiko Yamada, Takafumi Nakamura, Yasuo Urata, Hiroyuki Shimizu, Kenzaburo Tani:A novel oncolytic virotherapy by coxsackievirus B against human lung cancer without severe adverse events. 第16回 日本遺伝子治療学会,宇都宮,2010
  • Tomoko Inoue, Daisuke Sugiyama, Ryo Kurita, Kasem Kulkeaw, Hirotaka Kawano, Yoshie Miura, Michiyo Okada, Atsushi Takahashi, Tomotoshi Marumoto, Hiroyuki Inoue, Norio Komatsu, Kenzaburo Tani:APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cell.第16回 日本遺伝子治療学会,宇都宮,2010
  • Meada M, Nishimura Y, Kumagai N, Hayashi H, Miura Y, Kishimoto T, Otsuki t. functional analysis of human CD4+ T cells with decreased CXCR3 expression by long-term, low-dose exposure to asbestos. The Society of Toxicology (SOT) Annual Meeting in Salt Lake City, Utah,2010
  • Otsuki T, Maeda M, Miura Y, Kumagai N, Hayashi H, Yamamoto S, Nishimura Y. The effects of cntinuous long-term exposure to asbestos, chrysotile and crocidolite on HTLV=1 immortalized human T cell line, MT-2. The 10th International Congress of the iMiG (International Mesotheloma Interest Group) Kyoto ,2010
  • Atsushi Takahashi, Miki Ohira, Tadayuki Koda, Akira Nakagawara, Kenzaburo Tani:FEAT - A Novel Potent Tumor Promoter that is Aberrantly Overexpressed in Most Human Cancers. 第69回日本癌学会学術集会,大阪,2010
  • Saori Yamaguchi, Tomotoshi Marumoto, Takenobu Nii, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Atsushi Takahashi, Hiroyuki Inoue, Erika Sasaki, Shinji Okano, Yoshie Miura, Kenzaburo Tani. Oncogenic risk of induced pluripotent stem cells established from somatic cells with chromosome instability. American Society of Gene and Cell Therapy, 14th Annual Meeting, Seattle, 2011
  • Megumi Narusawa, Hiroyuki Inoue, Yoshihiro Tanaka, Yosuke Yokota, Chika Sakamoto, Shohei Miyamoto, Tomoko Inoue, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Kenzaburo Tani. Comparative microarray analysis implicates the pivotal participation of Type I Interferon related signaling pathway in antitumor effect provoked by in vivo GM-CSF gene transduced lung cancer cells. American Society of Gene and Cell Therapy,14th Annual Meeting, Seattle, 2011
  • Chika Sakamoto, Hiroyuki Inoue, Yusuke Murakami, Megumi Narusawa, Shohei Miyamoto, Ayumi Watanabe, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Kenzaburo Tani . GM-CSF gene-transduced murine cancer stem cells eliminate tumorigenicity in vivo. American Society of Gene and Cell Therapy,14th Annual Meeting, Seattle, 2011
  • Hirotaka Kawano, Tomotoshi Marumoto, Michiyo Okada, Tomoko Inoue, Takenobu Nii, Jiyuan Liao, Saori Yamaguchi, Yoko Nagai, Hiroyuki Inoue, Atsushi Takahashi, Erika Sasaki, Yoshie Miura, Kenzaburo Tani. LYL1, a Basic Helix-Loop-Helix Transcription Factor, Promotes Hematopoietic Differentiation of Common Marmoset Embryonic Stem Cells. American Society of Gene and Cell Therapy,14th Annual Meeting, Seattle, 2011
  • Hiroyuki Inoue, Shohei Miyamoto, Takafumi Nakamura, Meiko Yamada, Yasuo Urata, Toshihiko Okazaki, Tomotoshi Marumoto, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu, Kenzaburo Tani. Large-Scale Screening Identifies Coxsackievirus B3 (CVB3) as a Promising Oncolytic Virotherapy Agent against Non-Small Cell Lung Cancer. European Society for Gene and Cell Therapy, Brighton, 2011
  • Yosuke Yokota, Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Koichi Takayama, Yoichi Nakanishi, Takehiko Yokomizo,Kenzaburo Tani. Absence of LTB4/BLT1 axis promotes generation of long-lasting antitumor memory responses induced by administration of GM-CSF gene-transduced tumor cells, in a CD4+ T cell-dependent manner. 53th American Society of Hematology Annual Meeting and Exposition, San Diego, 2011
  • Jiyuan Liao, Tomotoshi Marumoto, Shinji Okano, Saori Yamaguchi, Takenobu Nii, Hirotaka Kawano, Yoko Nagai, Chika Sakamoto, Michiyo Okada, Yoshie Miura, Hiroyuki Inoue, Masato Tanaka, Kaori Nagatoshi, Kohichi Kawahara, Akira Suzuki, Kenzaburo Tani. Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells. 53th American Society of Hematology Annual Meeting and Exposition, San Diego, 2011
  • Takenobu Nii, Tomotoshi Marumoto, Hirotaka Kawano, Saori Yamaguchi, Yoko Nagai, Yoshie Miura, Jiyuan Liao, Michiyo Okada, Kenzaburo Tani. Efficient Differentiation of Common Marmoset Embryonic Stem Cells Into Hemangioblast-Like Cells by the Inhibition of PI3K-AKT Pathway. 53th American Society of Hematology Annual Meeting and Exposition, San Diego, 2011
  • Mutsunori Iga-Murahashi, Ysuki Hijikata, Yoko Suhiro, Hiroyuki Inoue, Yoshihiro Tanaka, Shinya Shimoda, Tomotoshi Marumoto, Toshihiko Okazaki, Atsusi Takahashi, Kenzaburo Tani. New strategy of antitumor immunetherapy targeting both tumor antigen and immune tolerance (Phase1 Clinical trial). 第9回日本臨床腫瘍学会学術集会, 横浜, 2011
  • Mutsunori Murahashi, Yasuki Hijikata, Junji Kishimoto, Masakazu Hirakawa, Shinji Okano,Yoshihiro Tanaka, Yoko Suehiro, Masaharu Nakayama, Hiroyuki Inoue, Tomotoshi Marumoto, Atsushi Takahashi, Toshihiko Okazaki, Yoichi Nakanishi, Koji Yoshida, Takuya Tsunoda, Yusuke Nakamura, Kenzaburo Tani.Phase I clinical trial of chemotherapy-combined cancer vaccine targeting both tumor antigen and immune tolerance against advanced solid tumors. American Society of Clinical Oncology, 2011
  • Megumi Narusawa, Hiroyuki Inoue, Yoshihiro Tanaka, Yosuke Yokota, Chika Sakamoto, Shohei Miyamoto, Tomoko Inoue, Kenzaburo Tani. Comparable transcriptional profile of murine mature dendritic cells in draining lymph node during tumor rejection by non-transmissible Sendai virus encoding GM-CSF infection. 第33回日本分子生物学会, 神戸, 2011
  • Megumi Narusawa, Hiroyuki Inoue,Yoshihiro Tanaka,Yosuke Yokota, Chika Sakamoto, Shohei Miyamoto, Tomoko Inoue,Makoto Inoue, Koichi Takayama, , Mamoru Hasegawa, Yoichi Nakanishi, Kenzaburo Tani. Diverse subtypes of DCs expressing Ly49D residing are dominantly induced in tumor draining lymph nodes during the regression of in vivo administration of GM-CSF gene transduced lung cancer cells. 第17回日本遺伝子治療学会, 福岡, 2011
  • Saori Yamaguchi, Tomotoshi Marumoto,Takenobu Nii , Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Atsushi Takahashi , Hiroyuki Inoue , Erika Sasaki , Shinji Okano , Yoshie Miura, Kenzaburo Tani. Characterization of embryonal carcinoma cells emerged in the process of iPSC generation from common marmoset fibroblasts. 第17回日本遺伝子治療学会, 福岡, 2011
  • Chika Sakamoto, Hiroyuki Inoue, Megumi Narusawa, Yosuke Yokota, Shohei Miyamoto, Ayumi Watanabe, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Kenzaburo Tani. GM-CSF gene-transduced murine cancer stem cells are susceptible to antitumor CD8+ T cell immunity. 第17回日本遺伝子治療学会, 福岡, 2011
  • Yosuke Yokota, Hiroyuki Inoue, Ayumi Watanabe, Chika Sakamoto, Megumi Narusawa, Shohei Miyamoto, Koichi Takayama, Yoichi Nakanishi, Takehiko Yokomizo and Kenzaburo Tani. Absence of LTB4/BLT1 axis enhances memory antitumor immunity responses induced by GM-CSF gene-transduced tumor cells, mainly in a CD4+ T cell dependent manner. 第17回日本遺伝子治療学会, 福岡, 2011
  • Hirotaka Kawano, Tomotoshi Marumoto, Michiyo Okada, Tomoko Inoue, Takenobu Nii, iyuan Liao, Saori Yamaguchi, Yoko Nagai, Hiroyuki Inoue, Erika Sasaki, Yoshie Miura, Kenzaburo Tani. A basic helix-loop-helix transcription factor Lyl1 regulates hematopoietic differentiation of common marmoset ES cells. 第17回日本遺伝子治療学会, 福岡, 2011
  • Atsushi Takahashi, Hisashi Tokita, Kenzo Takahashi, Tomoharu Takeoka, Kosho Murayama, Daihachiro Tomotsune, Miki Ohira, Tadayuki Koda, Akira Nakagawara, Kenzaburo Tani. TRANSGENIC MICE REVEAL A NOVEL POTENT TUMOR PROMOTER THAT IS ABERRANTLY OVEREXPRESSED IN MOST HUMAN CANCER. 第17回 日本遺伝子治療学会,九州大学医学部百年講堂, 福岡, 2011
  • Hiroyuki Inoue, Shohei Miyamoto, Meiko Yamada, Takafumi Nakamura, Beibei Wang, Kaname Nosaki,Yasuo Urata, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu, Kenzaburo Tani. Characterization of replication competent coxsackievirus B3 with oncolytic capacity against non small lung cancer cells. 第70回日本癌学会学術総会, 名古屋, 2011
  • Chika Sakamoto, Hiroyuki Inoue, Megumi Narusawa, Ayumi Watanabe, Shohei Miyamoto, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa,Yoichi Nakanishi, Kenzaburo Tani. 第70回日本癌学会学術総会, 名古屋, 2011
  • Saori Yamaguchi , Tomotoshi Marumoto, Takenobu Nii, Hirotaka Kawano , Jiyuan Liao, Yoko Nagai, Michiyo Okada , Atsushi Takahashi, Hiroyuki Inoue , Erika Sasaki, Shinji Okano, Yoshie Miura, Kenzaburo Tani. Characterization of embryonal carcinoma cells emerged in the process of iPS cell generation from common marmoset fibroblasts. 第70回日本癌学会学術総会, 名古屋, 2011
  • Yasuki Hijikata, Mutsunori Murahashi-Iga, Shinji Okano, Yoshihiro Tanaka, Kosuke Odaira, Atsushi Takahashi, Tomotoshi Marumoto, Hirouki Inoue, Toshihiko Okazaki, kenzaburo Tani. Development of Experimental Immune Therapies for Solid Tumors: Our Clinical Trial Experiences in Phase. 第73回日本血液学会学術集会, 名古屋, 2011
  • Hirotaka Kawano,Tomotoshi Marumoto, Michiyo Okada,Tomoko Inoue, Takenobu Nii, Jiyuan Liao, Saori Yamaguchi, Yoko Nagai,Hiroyuki Inoue , Erika Sasaki, Yoshie Miura,Kenzaburo Tani. LYL1 Promotes Hematopoietic Differentiation of Common Marmoset Embryonic Stem Cells. 第73回日本血液学会学術集会, 名古屋, 2011
  • Takenobu Nii, Tomotoshi Marumoto, Hirotaka Kawano, Saori Yamaguchi, Yoko Nagai, Yoshie Miura, Jiyuan Liao, Michiyo Okada, Kenzaburo Tani. A new technology to induce hemangioblasts from common marmoset ESCs by inhibiting PI3K-AKT pathway. 第73回日本血液学会学術集会, 名古屋, 2011
  • Atsushi Takahashi, Hisashi Tokita, Kenzo Takahashi, Tomoharu Takeoka, Kosho Murayama, Daihachiro Tomotsune, Miki Ohira, Tadayuki Koda, Akira Nakagawara, Kenzaburo Tani. FEAT – a novel potent tumor promoter aberrantly overexpressed in most human cancers. 第73回日本血液学会学術集会, 名古屋, 2011
  • 土方 康基、岡崎 利彦、村橋(伊賀) 睦了、田中 芳浩、大平 公亮、岡野 慎士、高橋 淳、丸本 朋稔、井上 博之、谷 憲三朗.RNF43ペプチドパルス樹状細胞ならびにRNF43ペプチド特異的活性化リンパ球を用いた進行固形腫瘍患者に対する強化養子免疫療法第Ⅰ相臨床試験.第3回造血器腫瘍免疫療法研究会学術集会, 別府, 2011

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学会発表2007~2009年

  • 岡田美智代,栗田良,及川達夫、横尾朋子、末廣陽子、佐々木えりか,谷憲三朗 新しい造血因子探索を目的としたヒト胎児肝レンチウイルス発現ライブラリーの構築 第69回日本血液学会、横浜、2007.10
  • Ryo Kurita, Tatsuo Oikawa, Michiyo Okada, Tomoko Yokoo, Norio Komatsu, Yoshikuni Tanioka, Erika Sasaki, and Kenzaburo Tani Construction of a high performance lentiviral cDNA library derived from human fetal liver American Society of Gene Therapy(ASGT) 10th Annual Meeting in Seattle, June
  • 横尾朋子, 栗田良, 谷憲三朗. コモンマーモセットES細胞への遺伝子導入による血球分化誘導系の現状と今後の展開. 「宮崎大学医学部/九州大学生医研 造血器腫瘍研究合同セミナー」2007.11.17(熊本)
  • Hiroyuki Inoue, Takafumi Nakamura, Terumasa Hisano, Meng Xin, Saori Asahi, Ryo Kurita, Koichi Takayama, Yoshikazu Yonemitsu, Makoto Inoue, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Non-transmissible SeV encoding murine GM-CSF, another potent vector system to produce autologous tumor vaccines. American Society of Gene Therapy(ASGT) 10th Annual Meeting in Seattle, June 2007.
  • Hiroyuki Inoue, Mutsunori Iga, Meng Xin, Ryo Kurita, Masaharu Nakayama, Yoko Suehiro, Yukoh Nakazaki, Koichi Takayama, Yoichi Nakanishi, Kenzaburo Tani.TARC and RANTES enhance immunological antitumor effect induced by GM-CSF transduced leukemia vaccine in mouse model. American Society of Hematology(ASJT) Annual Meeting and Exposition in Atlanta, December 2007.
  • Hiroyuki Inoue, Takafumi Nakamura, Terumasa Hisano, Meng Xin, Saori Asahi, Ryo Kurita, Koichi Takayama, Yoshikazu Yonemitsu, Makoto Inoue, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. In vivo antitumoer vaccine effects of non-transmissible SeV encoding GM-CSF in mouse renal cell carcinoma models. 2007年6月29日第13回 日本遺伝子治療学会 場所:愛知県立がんセンター
  • Hiroyuki Inoue, Terumasa Hisano, Mustunori Iga, Meng Xin, Saori Asahi, Ryo Kurita, Koichi Takayama, Yoshikazu Yonemitsu, Makoto Inoue, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Non-transmissible SeV(dF)-transduced autologous GM-CSF cancer vaccine cells as a candidate for immune gene therapy.  2007年10月2日 第66回 日本癌学会学術総会 場所:パシフィコ横浜
  • Ryo Kurita, Rui Kageyama, Yoshie Miura, Takafumi Hiramoto, Tomoko Yokoo, Michiyo Okada, Atsushi Takahashi, Hiroyuki Inoue, Kenzaburo Tani. In vitro induction of the hematopoietic progenitor/stem cells from human ES  cells ASGT 12th Annual Meeting, May 27 - 30, 2009, San Diego, CA
  • Hiroyuki Inoue, Mutsunori Iga, Haruka Nabeta, Meng Xin, Ryo Kurita, Koichi Takayama, Makoto Inoue, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Dendritic Cells Transduced with Granulocyte Macrophage Colony Stimulating Factor mediated by Non-Transmissible Sendai Virus Induce Therapeutic Antitumor Immunity in LLC Bearing Mice ASGT May 28-Jun 1,2008,Boston
  • Haruka Nabeta, Hiroyuki Inoue, Mutsunori Iga, Meng Xin, Ryo Kurita, Koichi Takayama, Yoichi Nakanishi, Takehiko Yokomizo and Kenzaburo Tani. Blocking LTB4 Signaling Maintains the Antitumor Effect of GM-CSF in the Tumor Challenge Model Using BLT-1-/-Mice ASGT May 28-Jun 1,2008,Boston
  • Hiroyuki Inoue, Mutsunori Iga, Haruka Nabeta, Koichi Takayama, Makoto Inoue, Yoichi Nakanishi, and Kenzaburo Tani. Immunotherapy with Autologous Dendritic Cells Activated by Non-transmissible Sendai Virus Encoding Granulocyte Macrophage-Colony Stimulating Factor Elicits Antitumor Immunity Against Lung Cancer in Mice APSR Nov 19-22,2009
  • Hiroyuki Inoue, Yosuke Yokota, Haruka Nabeta,Mutsunori Iga, Chika Sakamoto, Fumiyuki Sasaki, Yoichi Nakanishi, Takehiko Yokomizo and Kenzaburo Tani. Loss of LTB4 Signaling Confers the Long-Term Antileukemia Effects Induced by GM-CSF ?Transduced Tumor in BLT-1 deficient Mice. ASH 50th Annual Meeting and Exposition ,Dec 6-9,2008, SanFrancisco
  • Ming-Hsi Wang, Toshihiko Okazaki, Kim L. Isaacs, James D. Lewis, Duane T. Smoot, John F. Valentine, Themistocles Dassopoulos, Maria Oliva-Hemker, Mary L. Harris, Yuqiong Wu, Lisa W. Datta, Steven R. Brant. In African Americans, NOD2, SLC22A5 and ATG16L1 but not IL23R or IRGM are Genetic Risk Factors for Crohn’s Disease. Digestive Disease Week 2009 May 30-Jun 4, 2009,Chicago
  • Atsushi Takahashi . FEAT - enhancer of tumorigenesis commonly overexpressed in cancers. Gordon Research Conference on Cell Death . Jul 6-11 2008, Italy
  • 横尾朋子、栗田良、及川達夫、岡田美智代、末廣陽子、小松則夫、谷憲三朗 ヒト胎児肝レンチウイルス発現ライブラリーを用いたエリスロポエチン非依存的な赤芽球増殖因子の探索、 第70回 日本血液学会総会 、京都2008.10
  • 土方康基、伊賀睦了、末廣陽子、中山雅晴、岡崎利彦、村上佑介、田中芳浩、於昊龍、岡田美智代、吉田浩二、角田卓也、中村祐輔、谷憲三朗 進行・再発固形腫瘍(消化器癌・肺癌)に対するCyclophosphamide(CY)併用新規腫瘍関連抗 原由エピトープペプチドカクテルを用いた腫瘍特異的強化ワクチン療法の検討(第Ⅰ相臨床 試験)、第106回 日本内科学会総会、東京2009年4月10日~12日
  • Hiroyuki Inoue, Mutsunori Iga, Haruka Nabeta, Meng Xin, Ryo Kurita, Koichi Takayama, Makoto Inoue, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Enhanced antitumor immunity by adoptively transfused Sendai virus mediated GM-CSF transduced dendritic cells s in LLC bearing mice 第14回 日本遺伝子治療学会、札幌 2008年6月12日~14日
  • Hiroyuki Inoue, Haruka Nabeta, Mutsunori Iga, Meng Xin, Ryo Kurita, Koichi Takayama, Yoichi Nakanishi, Takehiko Yokomizo and Kenzaburo Tani. Blocking of the LTB4 signaling maintains the in vivo antitumor effects of GM-CSF transduced tumor cells第106回 日本内科学会総会、東京2009年4月10日~12日
  • Haruka Nabeta, Hiroyuki Inoue, Mutsunori Iga, Yosuke Yokota, Ryo Kurita, Fumiyuki Sasaki, Koichi Takayama, Yoichi Nakanishi, Takehiko Yokomizo and Kenzaburo Tani. Blocking of the LTB4 Signaling Maintains the in vivo Antitumor Effects of GM-CSF in the tumor challenged BLT-1-/- mice 第70回 日本血液学会総会、京都、2008年10月10~12日
  • Hiroyuki Inoue, Yosuke Yokota, Mutsunori Iga, Haruka Nabeta, Koichi Takayama, Makoto Inoue, Mamoru Hasegawa, Yoichi Nakanishi, and Kenzaburo Tani. Dendritic Cells Activated by Non-Transmissible Sendai Virus Encoding GM-CSF Induced Therapeutic Antitumor Immunity  第67回 日本癌学会学術総会、名古屋 2008年10月28日~30日
  • 井上 博之, , 伊賀 睦了, 孟 欣, 旭 沙織, 中村 貴史,栗田 良, 中山 雅晴, 中崎  有恒, 高山 浩一 中西 洋一, 谷 憲三朗. TARC及びRANTESは担癌マウスモデルにおいてGM-CSF遺伝子導入腫瘍ワクチン療法による 免疫学的抗腫瘍効果を増強する、第61回 日本呼吸器学会・日本結核病学会九州支部秋季学術講演会、沖縄 2008年11月6日~7日

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学会発表2002~2006年

  • Muta, H., Caceres, G., Ohata, P.J., Podack, ER (2001.3.31-4.4) CD30-ligand deficient mice are resistant to experimental allergic encephalitis Experimental Biology, オーランド
  • 曽田 泰、白 元松、伊沢清子、杉山 肇、田邊 剛、長村文孝、井関 徹、東條有伸、 谷 憲三朗、浅野茂隆 (2001.4.20) VSVシュ-ドタイプレンチウイルスベクター(HIV(VSV)vector)を用いたヒト血液細胞への遺伝子導入法の検討 日本血液学会、名古屋
  • BAI, Yuansong., Soda, Y., Izawa, K., Sasaki, E., Nakazaki, Y., Tanabe, T., Tomonari, A., Ooi, J., Nagamura, F., Uchimaru, K., Iseki, T., Miyoshi, H., Tojo, A., Tani, K. and Asano, S. (2001.4.20) Analysis of Gene Transduction System to Human Leukemia and Hematopoietic Stem Cells by Oncoretrovirus and Lentivirus Vectors 日本血液学会、名古屋
  • Yamashita, N., Hamada, h., Hase, H., Hanazawa, K., Aclift, S., Kawai, K., Tojo, A., Tomikawa, S., maekawa, T., Soda, y., Oyaizu, N., Tani, K., Watari, K., Sherwin, S., Takahashi, K., Wakumoto, Y., Ohata, j., Mulligan R., Machida, U., Okumura, K., Satoh, N., Monna M. and Nakazaki, Y.(2001.5.31) Case Reports on Clinical Studies of Immunogene Therapy Using Autologous 第4回アメリカ遺伝子治療学会、シアトル
  • Tani, K., Nakazaki, Y., Hase, H., Takahashi, K., Monna, M., Komine, F., Kitamura, R., Machida, U., Ohata, J., Soda, Y., Watari, K., Oyaizu, N., Sath, N., Tojo, A., Yamashita, N., Maekawa, T., Eriguchi, M., Tomikawa, S., Hanazawa, K., Wakumoto, Y., Kawai K., Azuma, M. Hamada, H., Okumura, K., Kakizoe, T., Akaza, H., Fujime, M., Mulligan, R., Clift, S., Ando, D., Sherwin, S. and Asano, S. (2001.7.5) Clinical Studies of Immunogene Therapy Using Autologous GM-CSF Transduced Tumor Vaccines(GVAX) for Stage IV Renal Cell Cancer: Progress Report 第7回日本遺伝子治療学会、東京
  • Soda, Y., Bai, Y., Izawa, K., Sasaki, E., Nakazaki, Y., Tanabe, T., Iseki, T., Tojo, A., Miyoshi, H., Tani, K. and Asano, S. (2001.7.7) Gene Transfer to Human Leukemia Cells, Lymphocytes and Hematopoietic Stem Cells with the Third Generation Lentiviral Vector 第7回日本遺伝子治療学会、東京
  • Kang X-X, Tani, K., Nakamura, Y. and Asano, S. (2001.7.7) Anti- and Angiogenic Gene Expressions in the Antitumor BAI-1 Gene Therapy 第7回日本遺伝子治療学会、東京
  • Kunisaki, R., Tani, K., Matsuda, S., Harata, M., Shuto, Y., Bai, Y., Tanabe, T., Sekihara, H. and Asano, S. (2001.7.7) Tob, a Novel Anti-Proliferative Tob/BTG2 Family Member, Drastically Suppress Tumor Growth and p53 Wild Human Lung Carcinoma Cells in vitro and in vivo, Sparing Damage to Nomal Cells 第7回日本遺伝子治療学会、東京
  • 国崎玲子、谷 憲三朗、松田 覚、原田雅充、首藤介伸、白 元松、田邊 剛、関原久彦、浅野茂隆 (2001.9.26) 新規癌抑制遺伝子;tobはp53野生肺癌細胞株に強力な抗腫瘍作用を呈し、かつ癌特異的な増殖抑制効果を示す。 第60回日本癌学会総会、横浜
  • 谷 憲三朗、中崎有恒、東條有伸、小柳津直樹、冨川伸二、和久本芳彰、河合弘二、東 みゆき、垣添忠生、藤目 真、赤座英之、浅野茂隆 (2001.9.27) GM-CSF遺伝子導入自家腎がん細胞を用いた免疫遺伝子治療臨床研究経過報告 第60回日本癌学会総会、横浜
  • Itaba, s., Chijiiwa, Y., Matsuzaka, H., Motomura, Y., Muta, H., Maeda, T.(2001.10.6-10) Inhibitory effect of c-type natriuretic peptide via both particulate and soluble guanylate cyclase in caecal circular smooth muscle cells. 9th United European Gastroenterology Week, アムステルダム
  • 谷 憲三朗、中崎有恒、長谷英徳、高橋圭介、大畑順子、町田詩子、曽田 泰、大岩真希、 前川 平、東條有伸、山下直秀、佐藤典治、江里口正純、冨川伸二、小柳津直樹、 和久本芳彰、花澤喜三郎、河合弘二、東みゆき、濱田洋文、垣添忠生、奥村 康、藤目 真、赤座英之、Shirley Clift, Dale Ando, Stephan Shirwin, Richard Mulligan, 浅野茂隆 (2001.10.10) GM-CSF遺伝子導入自家腎がん細胞を用いた免疫遺伝子治療臨床研究報告 第39回日本癌治療学会、東京
  • 谷 憲三朗、曽田 泰、白 元松、斎木 実、伊澤清子、田辺 剛、李 暁進、佐々木 えりか、中崎有恒、井関 徹、東條有伸、浅野茂隆、三好浩之(2001.11.1) 第三世代VSVシュードタイプレンチウイルスベクターによるヒト血液細胞への遺伝子 導入法の検討 第21回血液幹細胞シンポジウム、大阪
  • 谷 憲三朗、曽田 泰、白 元松、田邊 剛、浅野 茂隆、多比良和誠(2001.11.13) 新規リボザイムを用いた白血病治療法の開発 第43回日本臨床血液学会、神戸
  • Tani K., Nakazaki Y., Hase H., Takahashi K., Monna M., Komine F., Kitamura R., Machida U., Ohata J., Soda, Y., Watari K., Oyaizu N., Satoh N., Tojo A., Yamashita N., Maekawa T., Eriguchi M., Tomikawa S., Hanazawa K., Wakumoto Y., Kawai K., Azuma M., Hamada H., Okumura K., Kakizoe T., Akaza H., Fujime M., Mulligan R., Clift S., Ando D., Sherwin S. and Asano S. (2002.2.) Clinical Studies of Immunogene Therapy Using Autologous GM-CSF Transduced Tumor Vaccines(GVAX) for Stage IV Renal Cell Cancer: Progress Report The 5 US-Japan Gene Therapy Conference, Maryland.
  • Soda Y., Tani K., Bai Y., Takata I., Kuwabara Tl., Warashina M., Tanabe T., Saiki M., Chen M., Li X., Miyoshi H., Sugita K., Nakazawa S., Tojo A., Taira K., Asano S. (2002.7.19) Death of Ph1-Positive Acute Lymphoblastic Leukemia Cells with Transduction of Maxizyne Targeting Minor Bcr-Abl Fusion Gene Using a Third-Generation Lentiviral Vector System. 第8回日本遺伝子治療学会、東京.
  • Tani K. (2002.8.26) Case reports on clinical studies of Immunogene Therapy using autologous GM-CSF transduced tumor vaccines(GVAX) for stage IV renal cell cancer. The 29th World Congress of the International Society of Hematology、Seoul.
  •  Tani K. (2003.2.14) Development of Nnovel Molecular Therapy Targeting Philadelphia Positive Acute Lymphocytic Leukemia.NCI-JSPS Conference Program, Maui.
  • Yukoh Nakazaki, Yoshihito Beppu, Hidenori Hase, Kenzaburo Tani (2003, 7/31-8/1) The role and the efficacy of chemokines preferentially expressed in rejecting mouse tumor. The 23rd Summer Seminar, Sapporo Cancer Seminar, Sapporo
  • 橋口 隆生、中崎 有恒、谷 憲三朗 (2003, 12/10-13) GM-CSF免疫遺伝子治療を受けた腎細胞がん患者におけるSEREX抗原の探索 第26回日本分子生物学会年会、神戸
  •  Hashiguchi T, Nakazaki Y, Asano S, Tani K. Aug. 2004. Detection of enhanced serum antibody production to renal cell cancer proteins and identification of serological tumor antigens in patients treated with the GM-CSF gene-transduced autologous tumor vaccines (GVAX). The 10th Annual Meeting, Japanese Society of Gene Therapy, Tokyo
  •  Hashiguchi T, Nakazaki Y, Clift S, Ando DG, Asano S, Tani K. Jun.2004. Detection of enhanced serum antibody production to renal cell cancer proteins and identification of serological tumor antigens in patients treated with the GM-CSF gene-transduced autologous tumor vaccines (GVAX). The American Society of Gene Therapy's 7th Annual Meeting, Minneapolis, USA
  •  Hiroyuki Inoue,Terumasa Hisano,Yukoh Nakazaki,Gaku Sakaguchi,Ryo Kurita,Koichi Takayama,Yoichi Nakanishi,Kenzaburo Tani  June,2005 Relationship between the expression of membrane receptors(CAR,Integrin avb3,avb5)and adenoviral transduction efficiency American Society of Gene Therapy 8th Annual Meeting in St.Louis
  • Inoue H,Hisano T,Nakazaki Y,Kurita R,Takayama K,Nakanishi Y,Tani K Relationship Between Adenoviral Human GM-CSF Transduction Efficiency into Tumor Cells and their MembraneReceptors(CAR,Integrin av3,av5)
  • Hiroyuki Inoue,Takahumi Nakamura,Meng XIN.Gaku Sakaguchi,Ryo Kurita, HIidenori Hase,Yukoh Nakazaki,Yoshikazu Yonemitsu,Koichi Takayama,Yoichi Nakanishi,Shigetala Asano,Kenzaburo Tani,2006年8月  TARC enhanced the antitumor immune effect of GM-CSF in tumor vaccine model 第12回 日本遺伝子治療学会(JSGT),東京
  • Tomoko Yokoo , Ryo Kurita , Erika Sasaki, Kashiya Takasugi, Hideyuki Imoto, Yoshikuni Tanioka, Yasushi Soda, Kenzaburo Tani   , June, 2006 Production of megakaryocytes and platelets from common marmoset (Callithrix jacchus) ES cells by constitutive expression of tal1/scl gene American Society of Gene Therapy(ASGT) 9th Annual Meeting in Baltimore
  • Ryo Kurita, Tomoko Yokoo, Erika Sasaki, Yan Dong, Youko Suehiro, Yoshikuni Tanioka, Yasushi Soda, Norio Komatsu, Kenzaburo Tani.   Dec. 2006 Production of megakaryocytes and platelets from common marmoset (Callithrix jacchus) ES cells by constitutive expression of tal1/scl gene. American Society of Hematology, 48th Annual Meeting, Orlando

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