業績リスト
助教:鵜木 元香
原著論文  Original Research Papers
Unoki, M., Funabiki, H., Velasco, G., Francastel, C. & Sasaki, H.
CDCA7 and HELLS mutations undermine non-homologous end joining in centromeric instability syndrome.
J. Clin. Invest. 129, 78-92 (2019)
PubMed

Matsuda, S., Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotoh, K., Fukuda, K., Sasaki, H., Suzuki, T. & Kang, D.
Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA.
Sci. Rep. 8, 5801 (2018)
PubMed

Maenohara, S., Unoki, M., Toh, H., Ohishi, H., Sharif, J., Koseki, H. & Sasaki, H.
Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos.
PLoS Genet. 13, e1007042. (2017)
PubMed

Thijssen, P.E., Ito, Y., Grillo, G., Wang, J., Velasco, G., Nitta, H., Unoki, M., Yoshihara, M., Suyama, M., Sun, Y., Lemmers, R.J.L.F., de Greef, J.C., Gennery, A., Picco, P., Kloeckener-Gruissem, B., Gungor, T., Reisli, I., Picard, C., Kebaili, K., Roquelaure, B., Iwai, T., Kondo, I., Kubota, T., van Ostaijen-Ten Dam, M.M., van Tol, M.J.D., Weemaes, C., Francastel, C., van der Maarel, S.M. & Sasaki. H.
Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.
Nat. Commun. 6, 7870 (2015)
PubMed

Nitta, H., Unoki, M., Ichiyanagi, K., Kosho, T., Shigemura, T., Takahashi, H., Velasco, G., Francastel, C., Picard, C., Kubota, T. & Sasaki, H.
Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients.
J. Hum. Genet. 58, 455-460 (2013)
PubMed

Unoki, M., Masuda, A., Dohmae, N., Arita, K., Yoshimatsu, M., Iwai, Y., Fukui, Y., Ueda, K., Hamamoto, R., Shirakawa, M., Sasaki, H. & Nakamura, Y.
Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6).
J. Biol. Chem. 288, 6053-6062 (2013)
PubMed

Kofunato, Y., Kumamoto, K., Saitou, K., Hayase, S., Okayama, H., Miyamoto, K., Sato, Y., Katakura, K., Nakamura, I., Ohki, S., Koyama, Y., Unoki, M. & Takenoshita S.
UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer.
Oncol. Rep. 28, 1997-2002 (2012)
PubMed

Arita, K., Isogai, S., Oda, T., Unoki, M., Sugita, K., Sekiyama, N., Kuwata, K., Hamamoto, R., Tochio, H., Sato, M., Ariyoshi, M. & Shirakawa, M.
Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.
Proc. Natl. Acad. Sci. USA 109, 12950-12955 (2012)
PubMed

Cho, H.S., Suzuki, T., Dohmae, N., Hayami, S., Unoki, M., Yoshimatsu, M., Toyokawa, G., Takawa, M., Chen, T., Kurash, J.K., Field, H.I., Ponder, B.A., Nakamura, Y. & Hamamoto, R.
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.
Cancer Res. 71, 655-660 (2011)
PubMed

Unoki, M., Daigo, Y., Koinuma, J., Tsuchiya, E., Hamamoto, R. & Nakamura Y.
UHRF1 is a novel diagnostic marker of lung cancer.
Br. J. Cancer 103, 217-222 (2010)
PubMed

Yoshimatsu, M., Toyokawa, G., Hayami, S., Unoki, M., Tsunoda, T., Field, H.I., Kelly, J.D., Neal, D.E., Maehara, Y., Ponder, B.A.J., Nakamura, Y. & Hamamoto R..
Dysregulation of PRMT1 and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers.
Int. J. Can.128, 562-573 (2011)
PubMed

Hayami, S., Kelly, J.D., Cho, H.S., Yoshimatsu, M., Unoki, M., Tsunoda, T., Field, H.I., Neal, D.E., Yamaue, H., Ponder, B.A.J., Nakamura, Y. & Hamamoto, R.
Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers.
Int. J. Can.128, 574-586 (2011)
PubMed

Hayami, S., Yoshimatsu, M., Veerakumarasivam, A., Unoki, M., Iwai, Y., Tsunoda, T., Field, H.I., Kelly, J.D., Neal, D.E., Yamaue, H., Ponder, B.A.J., Nakamura, Y. & Hamamoto, R.
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.
Mol. Cancer.9, 59 (2010)
PubMed

Unoki, M., Kelly, J.D., Neal, D.E., Ponder, B.A., Nakamura, Y. & Hamamoto, R.
UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer.
Br. J. Cancer. 101, 98-105 (2009)
PubMed

Kumamoto, K., Fujita, K., Kurotani, R., Saito, M., Unoki, M., Hagiwara, N., Shiga, H., Bowman, E.D., Yanaihara, N., Okamura, S., Nagashima, M., Miyamoto, K., Takenoshita, S., Yokota, J. & Harris C.C.
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.
Int. J. Can. 125, 1306-1315 (2009)
PubMed

Unoki, M., Kumamoto, K., Robles, A.I., Shen, J.C., Zheng, Z.M. & Harris, C.C.
A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.
FEBS. Lett.582, 3868-3874 (2008)
PubMed

Unoki, M., Bronner, C. & Mousli, M.
A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1.
Radiat. Res. 169, 240-244 (2008)
PubMed

Brunet, J., Pfaff, A.W., Abidi, A., Unoki, M., Nakamura, Y., Guinard, M., Klein, J.P., Candolfi, E. & Mousli, M.
Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation.
Cell. Microbiol. 10, 908-920 (2008)
PubMed

Shen, J.C., Unoki, M., Ythier, D., Duperray, A., Varticovski, L., Kumamoto, K., Pedeux, R. & Harris, C.C.
Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1.
Cancer. Res. 67, 2552-2558 (2007)
PubMed

Unoki, M., Shen, J.C., Zheng, Z.M. & Harris, C.C.
Novel splice variants of ING4 and their possible roles in regulation of cell growth and motility.
J. Biol. Chem. 281, 34677-34686 (2006)
PubMed

Unoki, M., Nishidate, T. & Nakamura, Y.
ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.
Oncogene 23, 7601-7610 (2004)
PubMed

Unoki, M. & Nakamura Y.
Methylation at CpG-islands in intron1 of EGR2 confers enhancer-like activity.
FEBS. Lett. 554, 67-72 (2003)
PubMed

Unoki, M. & Nakamura Y.
EGR2 induces apoptosis in various cancer-cell lines by direct transactivation of BNIP3L and BAK.
Oncogene 22, 2172-2185 (2003)
PubMed

Unoki, M., Okutsu, J. & Nakamura Y.
Identification of ZFP91 gene involved in acute myelogenous leukemia.
Int. J. Oncol. 22, 1217-1224 (2003)
PubMed

Unoki, M. & Nakamura Y.
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.
Oncogene 20, 4457-4465 (2001)
PubMed

Suzuki, C., Unoki M. & Nakamura Y.
Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes.
J. Hum. Genet. 46, 155-157 (2001)
PubMed

Matsushima-Nishiu, M., Unoki, M., Ono, K., Tsunoda, T., Minaguchi, T., Kuramoto, H., Nishida, M., Satoh, T., Tanaka, T. & Nakamura Y.
Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.
Cancer Res. 61, 3741-3749 (2001)
PubMed

Takeoka, S., Unoki, M., Onouchi, Y., Doi, S., Fujiwara, H., Miyatake, A., Fujita, K., Inoue, I., Nakamura, Y. & Tamari, M.
Amino-acid substitutions in the IKAP gene product significantly increase risk for bronchial asthma in children.
J. Hum. Genet. 46, 57-63 (2001)
PubMed

Yamada, R., Tanaka, T., Unoki, M., Nagai, T., Sawada, T., Ohnishi, Y., Tsunoda, T., Yukioka, M., Maeda, A., Suzuki, K., Tateishi, H., Ochi, T., Nakamura, Y. & Yamamoto, K.
Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease.
Am. J. Hum. Genet. 68, 674-685 (2001)
PubMed

Unoki, M., Furuta, S., Onouchi, Y., Watanabe, O., Doi, S., Fujiwara, H., Miyatake, A., Fujita, K., Tamari, M. & Nakamura, Y.
Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene.
Hum. Genet. 106, 440-446 (2000)
PubMed

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総説 Reviews / 英文 English
Mori, T., Ikeda, D.D., Yamaguchi, Y., Unoki, M., NIRF Project.
NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape.
FEBS Lett. 586, 1570-1583 (2012)
PubMed

Unoki, M.
Current and potential anticancer drugs targeting members of the UHRF1 complex including epigenetic modifiers.
Recent Pat. Anticancer Drug Discov. 6, 116-130 (2011)
PubMed

Unoki, M., Brunet, J. & Mousli M.
Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis.
Biochem. Pharmacol. 78, 1279-1288 (2009)
PubMed

Unoki, M., Kumamoto, K. & Harris, C.C.
ING proteins as potential anticancer drug targets.
Curr. Drug Targets 10, 442-454 (2009)
PubMed

Unoki, M., Kumamoto, K., Takenoshita, S. & Harris, C.C.
Reviewing the current classification of inhibitor of growth family proteins.
Cancer Sci. 100, 1173-1179 (2009)
PubMed

総説 Reviews / 和文 Japanese
前之原章司,鵜木元香
領域特異的バイサルファイトシークエンシング
実験医学別冊 エピジェネティクス実験スタンダード(牛島俊和・眞貝洋一・塩見春彦編集), 36-42 (2017)

鵜木元香, 佐々木裕之
エピジェネティック調節(DNAメチル化)
生体の科学 66 (特集) 細胞シグナル操作法, 474-475 (2015)

鵜木元香
腎細胞癌とエピジェネティクス
Kidney Cancer No.3, 18-21, グラクソ・スミスクライン株式会社 (2015)

鵜木元香, 新田洋久, 佐々木裕之
DNAメチル化酵素異常症
遺伝子医学MOOK 25 エピジェネティクスと病気 (佐々木裕之監修, 中尾光善・中島欽一編集), 210-216 (2013)

鵜木元香, 佐々木裕之
発生におけるエピジェネティクスとその破綻
シグマライフサイエンスニュース・エピジェネティクス特集 2012 Winter, 2-8 (2012)

鵜木元香, 中村祐輔
cDNAマイクロアレイを利用した癌抑制遺伝子シグナル伝達経路の研究〜PTENを中心に〜
Bioベンチャー 7-8月号, 22-26, 羊土社 (2003)

鵜木元香
第3章 細胞レベルでの遺伝子機能解析、10 アデノウイルスベクターの作製
基礎からわかるゲノム解析実験法 中村祐輔ラボ・マニュアル 191-200, 羊土社(2002)

著書 Books / 英文 English  
Unoki, M. & Sasaki, H.
ICF syndrome.
Encyclopedia of Cancer 1-5, Springer Berlin Heidelberg (2015)

Unoki, M.
UHRF1 is a potential molecular marker for diagnosis and prognosis of bladder cancer.
Bladder Cancer 129-146, InTech (2012)

著書 Books / 和文 Japanese  
鵜木元香
生まれつきの女王蜂はいない DNAだけでは決まらない遺伝子の使い道
1-192 講談社(2016)

鵜木元香, 佐々木裕之
第5章: 生殖細胞形成と個体発生におけるエピジェネティクス
エピジェネティクスの産業応用 (畑田出穂, 久保田健夫監修), 78-89 シーエムシー出版 (2014)

鵜木元香, 佐々木裕之
第2部-4: 生殖・発生
エピジェネティクスキーワード事典 (牛島俊和, 真貝洋一編), 123-129 羊土社 (2013)

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