近畿大学 教授：佐渡 敬
原著論文 Original Research Papers
- Ohishi, H.*, Au Yeung, W.K.*, Unoki, M., Ichiyanagi, K., Fukuda, K., Maenohara, S., Shirane, K., Chiba, H., Sado, T. & Sasaki, H. (*These authors equally contributed to the work.)
- Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells.
- Genes Cells 25, 54-64 (2020)
PubMed
- Sakakibara, Y., Nagao, K., Blewitt, M., Sasaki, H., Obuse, C. & Sado, T.
- Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice.
- Development 145, dev166462 (2018)
- PubMed
- Chigi, Y., Sasaki, H. & Sado, T.
- The 5' region of Xist RNA has the potential to associate with chromatin through the A-repeat.
- RNA 23, 1894-1901 (2017)
- PubMed
- Sakata, Y., Nagao, K., Hoki, Y., Sasaki, H., Obuse, C. & Sado, T.
- Defects in dosage compensation impact global gene regulation in the mouse trophoblast.
- Development 144, 2784-2797 (2017)
- PubMed
- Amakawa, Y., Sakata, Y., Hoki, Y., Arata, S., Shioda, S., Fukagawa, T., Sasaki, H. & Sado, T.
- A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.
- Development 142, 4299-4308 (2015)
- PubMed
- Yamamoto, Y., Watanabe, T., Hoki, Y., Shirane, K., Li, Y., Ichiyanagi, K., Kuramochi-Miyagawa, S., Toyoda, A., Fujiyama, A., Oginuma, M., Suzuki, H., Sado, T., Nakano, T. & Sasaki, H.
- Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus.
- Genome Res. 23, 292-299 (2013)
- PubMed
- Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D. & Sasaki, H.
- Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.
- Science 332, 848-52 (2011)
- PubMed
- Hoki, Y., Ikeda, R., Mise, N., Sakata, Y., Ohhata, T., Sasaki, H., Abe, K. & Sado, T.
- Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse
- Development 138, 2649-59 (2011)
- PubMed
- Watanabe, T., Chuma, S. Yamamoto, Y., Kuramochi-Miyagawa, S., Totoki, Y., Toyoda, A., Hoki, Y., Fujiyama, A., Shibata, T., Sado, T., Noce, T., Nakano, T., Nakatsuji, N., Lin, H. & Sasaki, H.
- MitoPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.
- Dev. Cell 20, 364-375 (2011)
- PubMed
- Inoue, K., Kohda, T., Sugimoto, M., Sado, T., Ogonuki, N., Matoba, S., Shiura, H., Ikeda, R., Mochida, K., Fujii, T., Sawai, K., Otte, A.P., Tian, X.C., Yang, X., Ishino, F., Abe, K. & Ogura, A..
- Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer.
- Science 330, 496-499 (2010)
- PubMed
- Hoki, Y., Kimura, N., Kanbayashi, M., Ohhata, T., Amakawa, Y., Sasaki, H. & Sado, T.
- A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.
- Development 136, 139-146 (2009)
- PubMed
- Nesterova, T.B., Popova, B.C., Cobb, B.S., Norton, S., Senner, C.E., Tang, Y.A., Spruce, T., Rodriguez, T.A. & Sado, T.
- Merkenschlager M. and Brockdorff N. Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a.
- Epigenetics & Chromatin 1:2 (2008)
- PubMed
- Chiba, H., Hirasawa, R., Kaneda, M., Amakawa, Y., Li, E., Sado, T. & Sasaki, H.
- De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes.
- Genesis 46, 768-774 (2008)
- PubMed
- Ohhata, T., Hoki, Y., Sasaki, H. & Sado, T.
- Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification.
- Development 135, 227-235 (2008)
- PubMed
- Sado, T., Hoki, Y. & Sasaki, H.
- Tsix defective in splicing is competent to establish Xist silencing.
- Development 133(24): 4925-4931 (2006)
- PubMed
- Ohhata, T., Hoki, Y., Sasaki, H. & Sado, T.
- Tsix-deficent X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.
- Cytogenet. Genome Res. 113 (Special Issue on Genomic Imprinting), 345-349 (2006)
- PubMed
- Sado, T., Hoki, Y. & Sasaki, H.
- Tsix silences Xist through modification of chromatin structure.
- Dev. Cell 9, 159-165 (2005)
- PubMed
- Kaneda, M., Sado, T., Okano, M., Hata, K., Tsujimoto, N., Li, E. & Sasaki, H.
- Role of de novo DNA methyltransferases in initiation of genomic imprinting and X-chromosome inactivation.
- Cold Spring Harbor Symp. Quant. Biol. 69, 125-129 (2004)
- PubMed
- Purbowasito, W., Suda, C., Yokomine, T., Zubair, M., Sado, T., Tsutsui, K. & Sasaki, H.
- Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7.
- DNA Res. 11, 391-407 (2004)
- PubMed
- Ohhata, T., Tachibana, M., Tada, M., Tada, T., Sasaki, H., Shinkai, Y. & Sado, T.
- X-inactivation is stably maintained in mouse embryos deficient for histone methyltransferase G9a.
- Genesis 40, 151-156 (2004)
- PubMed
- Kaneda, M., Okano, M., Hata, K., Sado, T., Tsujimoto, N., Li, E. & Sasaki, H.
- Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.
- Nature 429, 900-903 (2004)
- PubMed
- Sado, T., Okano, M., Li, E. & Sasaki, H.
- De novo methylation is dispensable for the initiation and propagation of X chromosome inactivation.
- Development 131, 957-982 (2004)
- PubMed
- Sado, T., Li, E. & Sasaki, H.
- Effect of Tsix-disruption on Xist expression in male ES cells.
- Cytogenet. Genome Res. 99, 115-118 (2002)
- PubMed
- Shirohzu, H., Kubota, T., Kumazawa, A., Sado, T., Chijiwa, T., Inagaki, K., Suetake, I., Tajima, S., Wakui, K., Miki, Y., Hayashi, M., Fukushima, Y. & Sasaki, H.
- Three novel DNMT3B mutations in Japanese patients with ICF syndrome.
- Am. J. Med. Genet. 112, 31-37 (2002)
- PubMed
- Takebayashi, S., Nakao, M., Fujita, N., Sado, T., Tanaka, M., Taguchi, H. & Okumura, K.
- 5-Aza-2-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation.
- Biochem. Biophys. Res. Commun. 288, 921-926, (2001)
- PubMed
- Sado, T., Wang, Z., Sasaki, H. & Li, E.
- Regulation of imprinted X-chromosome inactivation in mice by Tsix.
- Development 128, 1275-1286 (2001)
- PubMed
- Grandjean, V., O'Neill, L., Sado, T., Turner, B. & Ferguson-Smith, A.
- Relationship between DNA methylation, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H19 domain.
- FEBS Lett. 488, 165-169 (2001)
- PubMed
- Sado, T., Fenner, M. H., Tan, S-S., Tam, P., Shioda, T. & Li, E.
- X-inactivation in the mouse embryo deficient for Dnmt1: Distinct effect of hypomethylation on imprinted and random X-inactivation.
- Dev. Biol. 225, 294-303 (2000)
- PubMed
- Nishita, Y., Sado, T., Yoshida, I. & Takagi, N.
- Effect of CpG methylation on expression of mouse imprinted gene Mest.
- Gene 226, 199-209 (1998)
- PubMed
- Schuster-Gossler, K., Bilinski, P., Sado, T., Ferguson-Smith, A. & Gossler, A.
- The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA.
- Dev. Dyn. 212, 214-228 (1998)
- PubMed
- Tada, T., Tada, M., Hilton, K., Barton, S. C., Sado, T., Takagi, N. & Surani, M. A.
- Epigenotype switching of imprintable loci in embryonic germ cells.
- Dev. Genes and Evol. 207, 551-561 (1998)
- PubMed
- Nishita, Y., Yoshida, I., Sado, T. & Takagi, N.
- Genomic imprinting and chromosomal localization of the human MEST gene.
- Genomics 36, 539-542 (1996)
- PubMed
- Mise, N., Sado, T., Tada, M., Takada, S. & Takagi, N.
- Activation of the inactive X chromosome induced by cell fusion between a murine EC and female somatic cell accompanies reproducible changes in the methylation pattern of the Xist gene.
- Exp. Cell Res.223, 193-202 (1996)
- PubMed
- Sado, T., Tada, T. & Takagi, N.
- Mosaic methylation of Xist gene before chromosome inactivation in undifferentiated female mouse embryonic stem and embryonic germ cells.
- Dev. Dyn. 205, 421-434 (1996)
- PubMed
- Nakajima, N. & Sado, T.
- Nucleotide sequence of a mouse lamin A cDNA and its deduced amino acid sequence.
- Biochim. Biophys. Acta. 1171, 311-314 (1993)
- PubMed
- Sado, T., Nakajima, N., Tada, M. & Takagi, N.
- A novel mesoderm-specific cDNA isolated from a mouse embryonal carcinoma cell line.
- Dev. Growth and Differ. 35, 551-560 (1993)
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総説 Reviews / 英文 English
- Nakajima, T. & Sado, T.
- Current view of the potential roles of proteins enriched on the inactive X chromosome.
- Genes Genet Syst. 89, 151-157 (2014)
- PubMed
- Sado, T. & Sakaguchi, T.
- Species-specific differences in X chromosome inactivation in mammals.
- Reproduction 146, R131-R139 (2013)
- PubMed
- Sado, T. & Brockdorff, N.
- Advances in understanding chromosome silencing by the long non-coding RNA Xist.
- Philos Trans R Soc Lond B Biol Sci. 368, (1609) 20110325 (2013)
- PubMed
- Sado, T. & Ferguson-Smith, A. C.
- Imprinted X inactivation and reprogramming in the preimplantation mouse embryo.
- Hum. Mol. Genet. 14, Spec. 1, R59-64. (2005)
- PubMed
総説 Reviews / 和文 Japanese
- 中島達郎，酒田祐佳，佐渡敬
- lncRNAの遺伝学的解析
- 実験医学別冊 エピジェネティクス実験スタンダード（牛島俊和・眞貝洋一・塩見春彦編集）, 299-310 (2017)
- 坂口武久, 佐渡敬
- ノンコーディングRNAとエピジェネティクス
- 遺伝子医学MOOK 25 エピジェネティクスと病気 (佐々木裕之監修, 中尾光善・中島欽一編集), 43-49 (2013)
- 酒田祐佳, 佐渡敬
- X染色体不活性化：RNAによるエピジェネティックな発生制御
- 実験医学 30, 2908-2915, (2012)
- 佐渡敬
- 哺乳類X染色体のエピジェネティック制御とノンコーディングRNA
- 医学のあゆみ (第5土曜特集)RNA医学・医療―新たな診断・治療を拓く 238, 407-412, (2011)
- 佐渡敬, 佐々木裕之（監修）
- 特集ノンコーディングRNAによるエピジェネティック制御機構
- 細胞工学 30, 7 (2011)
- 佐渡敬
- X染色体不活性化のエピジェネティクス
- 実験医学 28 (増刊号), 74-80 (2010)
- 佐渡敬
- 細胞核内機能性RNA「Xist」―その機能と制御はどこまでわかったか？
- 実験医学 27 (増刊号), 139-145 (2009)
- 佐渡敬, 佐々木裕之
- 哺乳類のエピジェネティクス
- 生物の科学：遺伝 63, 65 - 70 (2009)
- 佐渡敬
- X染色体不活性化を担うXist遺伝子のアンチセンス制御
- 遺伝 別冊 70-74 (2007)
- 佐渡敬
- 機能性RNAによるダイナミックな染色体の活性制御―哺乳類X染色体不活性化のしくみ
- 科学 5月号 512-516 (2006)
- 佐渡敬, 大畑樹也
- マウス胚体外組織におけるインプリント型X染色体不活性化
- Mol.Med. 42, 173-180 (2004)
- 佐渡敬
- X染色体遺伝子量補償
- ゲノム医科学 4, 51-57 (2004)
- 佐渡敬
- X染色体不活性化を制御するnon-coding RNA
- 実験医学 増刊号 21, 129-135 (2003)
- 佐渡敬
- X染色体不活性化とインプリンティング
- 医学のあゆみ 202，257-258 (2002)
- 佐渡敬, 佐々木裕之
- ほ乳類の発生におけるDNAメチル化の役割
- 細胞工学 20, 351-355 (2001)
- 佐渡敬, 佐々木裕之
- 生殖遺伝学とインプリンティング
- 病理と臨床 18, 1223-1226 (2000)
著書 Books / 和文 Japanese
- 佐渡敬
- 第2部-1: X染色体不活性化
- エピジェネティクスキーワード事典 (牛島俊和, 真貝洋一編), 100-108 羊土社 (2013)
- 佐渡敬
- 第IV-14章: 卵子とX染色体
- 卵子学 (森崇英総編集), 147-154, 京都大学学術出版会 (2011)
- 佐渡敬
- 性染色体の遺伝子量補償 (エピジェネティクス, 佐々木裕之編)
- Springer Reviews シリーズ シュプリンガー・フェアラーク東京 117-127（2004）
- 佐渡敬, 佐々木裕之
- 性染色体の構造と機能
- Springer Reviews シリーズ クロマチンと遺伝子機能制御 (堀越正美編), 15-24, シュプリンガー・フェアラーク東京 (2003)
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