業績リスト
近畿大学 教授:佐渡 敬
原著論文  Original Research Papers
Sakakibara, Y., Nagao, K., Blewitt, M., Sasaki, H., Obuse, C. & Sado, T.
Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice.
Development 145, dev166462 (2018)
PubMed

Chigi, Y., Sasaki, H. & Sado, T.
The 5' region of Xist RNA has the potential to associate with chromatin through the A-repeat.
RNA 23, 1894-1901 (2017)
PubMed

Sakata, Y., Nagao, K., Hoki, Y., Sasaki, H., Obuse, C. & Sado, T.
Defects in dosage compensation impact global gene regulation in the mouse trophoblast.
Development 144, 2784-2797 (2017)
PubMed

Amakawa, Y., Sakata, Y., Hoki, Y., Arata, S., Shioda, S., Fukagawa, T., Sasaki, H. & Sado, T.
A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.
Development 142, 4299-4308 (2015)
PubMed

Yamamoto, Y., Watanabe, T., Hoki, Y., Shirane, K., Li, Y., Ichiyanagi, K., Kuramochi-Miyagawa, S., Toyoda, A., Fujiyama, A., Oginuma, M., Suzuki, H., Sado, T., Nakano, T. & Sasaki, H.
Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus.
Genome Res. 23, 292-299 (2013)
PubMed

Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D. & Sasaki, H.
Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.
Science 332, 848-52 (2011)
PubMed

Hoki, Y., Ikeda, R., Mise, N., Sakata, Y., Ohhata, T., Sasaki, H., Abe, K. & Sado, T.
Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse
Development 138, 2649-59 (2011)
PubMed

Watanabe, T., Chuma, S. Yamamoto, Y., Kuramochi-Miyagawa, S., Totoki, Y., Toyoda, A., Hoki, Y., Fujiyama, A., Shibata, T., Sado, T., Noce, T., Nakano, T., Nakatsuji, N., Lin, H. & Sasaki, H.
MitoPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.
Dev. Cell 20, 364-375 (2011)
PubMed

Inoue, K., Kohda, T., Sugimoto, M., Sado, T., Ogonuki, N., Matoba, S., Shiura, H., Ikeda, R., Mochida, K., Fujii, T., Sawai, K., Otte, A.P., Tian, X.C., Yang, X., Ishino, F., Abe, K. & Ogura, A..
Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer.
Science 330, 496-499 (2010)
PubMed

Hoki, Y., Kimura, N., Kanbayashi, M., Ohhata, T., Amakawa, Y., Sasaki, H. & Sado, T.
A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.
Development 136, 139-146 (2009)
PubMed

Nesterova, T.B., Popova, B.C., Cobb, B.S., Norton, S., Senner, C.E., Tang, Y.A., Spruce, T., Rodriguez, T.A. & Sado, T.
Merkenschlager M. and Brockdorff N. Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a.
Epigenetics & Chromatin 1:2 (2008)
PubMed

Chiba, H., Hirasawa, R., Kaneda, M., Amakawa, Y., Li, E., Sado, T. & Sasaki, H.
De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes.
Genesis 46, 768-774 (2008)
PubMed

Ohhata, T., Hoki, Y., Sasaki, H. & Sado, T.
Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification.
Development 135, 227-235 (2008)
PubMed

Sado, T., Hoki, Y. & Sasaki, H.
Tsix defective in splicing is competent to establish Xist silencing.
Development 133(24): 4925-4931 (2006)
PubMed

Ohhata, T., Hoki, Y., Sasaki, H. & Sado, T.
Tsix-deficent X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.
Cytogenet. Genome Res. 113 (Special Issue on Genomic Imprinting), 345-349 (2006)
PubMed

Sado, T., Hoki, Y. & Sasaki, H.
Tsix silences Xist through modification of chromatin structure.
Dev. Cell 9, 159-165 (2005)
PubMed

Kaneda, M., Sado, T., Okano, M., Hata, K., Tsujimoto, N., Li, E. & Sasaki, H.
Role of de novo DNA methyltransferases in initiation of genomic imprinting and X-chromosome inactivation.
Cold Spring Harbor Symp. Quant. Biol. 69, 125-129 (2004)
PubMed

Purbowasito, W., Suda, C., Yokomine, T., Zubair, M., Sado, T., Tsutsui, K. & Sasaki, H.
Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7.
DNA Res. 11, 391-407 (2004)
PubMed

Ohhata, T., Tachibana, M., Tada, M., Tada, T., Sasaki, H., Shinkai, Y. & Sado, T.
X-inactivation is stably maintained in mouse embryos deficient for histone methyltransferase G9a.
Genesis 40, 151-156 (2004)
PubMed

Kaneda, M., Okano, M., Hata, K., Sado, T., Tsujimoto, N., Li, E. & Sasaki, H.
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.
Nature 429, 900-903 (2004)
PubMed

Sado, T., Okano, M., Li, E. & Sasaki, H.
De novo methylation is dispensable for the initiation and propagation of X chromosome inactivation.
Development 131, 957-982 (2004)
PubMed

Sado, T., Li, E. & Sasaki, H.
Effect of Tsix-disruption on Xist expression in male ES cells.
Cytogenet. Genome Res. 99, 115-118 (2002)
PubMed

Shirohzu, H., Kubota, T., Kumazawa, A., Sado, T., Chijiwa, T., Inagaki, K., Suetake, I., Tajima, S., Wakui, K., Miki, Y., Hayashi, M., Fukushima, Y. & Sasaki, H.
Three novel DNMT3B mutations in Japanese patients with ICF syndrome.
Am. J. Med. Genet. 112, 31-37 (2002)
PubMed

Takebayashi, S., Nakao, M., Fujita, N., Sado, T., Tanaka, M., Taguchi, H. & Okumura, K.
5-Aza-2-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation.
Biochem. Biophys. Res. Commun. 288, 921-926, (2001)
PubMed

Sado, T., Wang, Z., Sasaki, H. & Li, E.
Regulation of imprinted X-chromosome inactivation in mice by Tsix.
Development 128, 1275-1286 (2001)
PubMed

Grandjean, V., O'Neill, L., Sado, T., Turner, B. & Ferguson-Smith, A.
Relationship between DNA methylation, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H19 domain.
FEBS Lett. 488, 165-169 (2001)
PubMed

Sado, T., Fenner, M. H., Tan, S-S., Tam, P., Shioda, T. & Li, E.
X-inactivation in the mouse embryo deficient for Dnmt1: Distinct effect of hypomethylation on imprinted and random X-inactivation.
Dev. Biol. 225, 294-303 (2000)
PubMed

Nishita, Y., Sado, T., Yoshida, I. & Takagi, N.
Effect of CpG methylation on expression of mouse imprinted gene Mest.
Gene 226, 199-209 (1998)
PubMed

Schuster-Gossler, K., Bilinski, P., Sado, T., Ferguson-Smith, A. & Gossler, A.
The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA.
Dev. Dyn. 212, 214-228 (1998)
PubMed

Tada, T., Tada, M., Hilton, K., Barton, S. C., Sado, T., Takagi, N. & Surani, M. A.
Epigenotype switching of imprintable loci in embryonic germ cells.
Dev. Genes and Evol. 207, 551-561 (1998)
PubMed

Nishita, Y., Yoshida, I., Sado, T. & Takagi, N.
Genomic imprinting and chromosomal localization of the human MEST gene.
Genomics 36, 539-542 (1996)
PubMed

Mise, N., Sado, T., Tada, M., Takada, S. & Takagi, N.
Activation of the inactive X chromosome induced by cell fusion between a murine EC and female somatic cell accompanies reproducible changes in the methylation pattern of the Xist gene.
Exp. Cell Res.223, 193-202 (1996)
PubMed

Sado, T., Tada, T. & Takagi, N.
Mosaic methylation of Xist gene before chromosome inactivation in undifferentiated female mouse embryonic stem and embryonic germ cells.
Dev. Dyn. 205, 421-434 (1996)
PubMed

Nakajima, N. & Sado, T.
Nucleotide sequence of a mouse lamin A cDNA and its deduced amino acid sequence.
Biochim. Biophys. Acta. 1171, 311-314 (1993)
PubMed

Sado, T., Nakajima, N., Tada, M. & Takagi, N.
A novel mesoderm-specific cDNA isolated from a mouse embryonal carcinoma cell line.
Dev. Growth and Differ. 35, 551-560 (1993)

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総説 Reviews / 英文 English
Nakajima, T. & Sado, T.
Current view of the potential roles of proteins enriched on the inactive X chromosome.
Genes Genet Syst. 89, 151-157 (2014)
PubMed

Sado, T. & Sakaguchi, T.
Species-specific differences in X chromosome inactivation in mammals.
Reproduction 146, R131-R139 (2013)
PubMed

Sado, T. & Brockdorff, N.
Advances in understanding chromosome silencing by the long non-coding RNA Xist.
Philos Trans R Soc Lond B Biol Sci. 368, (1609) 20110325 (2013)
PubMed

Sado, T. & Ferguson-Smith, A. C.
Imprinted X inactivation and reprogramming in the preimplantation mouse embryo.
Hum. Mol. Genet. 14, Spec. 1, R59-64. (2005)
PubMed

総説 Reviews / 和文 Japanese
中島達郎,酒田祐佳,佐渡敬
lncRNAの遺伝学的解析
実験医学別冊 エピジェネティクス実験スタンダード(牛島俊和・眞貝洋一・塩見春彦編集), 299-310 (2017)

坂口武久, 佐渡敬
ノンコーディングRNAとエピジェネティクス
遺伝子医学MOOK 25 エピジェネティクスと病気 (佐々木裕之監修, 中尾光善・中島欽一編集), 43-49 (2013)

酒田祐佳, 佐渡敬
X染色体不活性化:RNAによるエピジェネティックな発生制御
実験医学 30, 2908-2915, (2012)

佐渡敬
哺乳類X染色体のエピジェネティック制御とノンコーディングRNA
医学のあゆみ (第5土曜特集)RNA医学・医療―新たな診断・治療を拓く 238, 407-412, (2011)

佐渡敬, 佐々木裕之(監修)
特集ノンコーディングRNAによるエピジェネティック制御機構
細胞工学 30, 7 (2011)

佐渡敬
X染色体不活性化のエピジェネティクス
実験医学 28 (増刊号), 74-80 (2010)

佐渡敬
細胞核内機能性RNA「Xist」―その機能と制御はどこまでわかったか?
実験医学 27 (増刊号), 139-145 (2009)

佐渡敬, 佐々木裕之
哺乳類のエピジェネティクス
生物の科学:遺伝 63, 65 - 70 (2009)

佐渡敬
X染色体不活性化を担うXist遺伝子のアンチセンス制御
遺伝 別冊 70-74 (2007)

佐渡敬
機能性RNAによるダイナミックな染色体の活性制御―哺乳類X染色体不活性化のしくみ
科学 5月号 512-516 (2006)

佐渡敬, 大畑樹也
マウス胚体外組織におけるインプリント型X染色体不活性化
Mol.Med. 42, 173-180 (2004)

佐渡敬
X染色体遺伝子量補償
ゲノム医科学 4, 51-57 (2004)

佐渡敬
X染色体不活性化を制御するnon-coding RNA
実験医学 増刊号 21, 129-135 (2003)

佐渡敬
X染色体不活性化とインプリンティング
医学のあゆみ 202,257-258 (2002)

佐渡敬, 佐々木裕之
ほ乳類の発生におけるDNAメチル化の役割
細胞工学 20, 351-355 (2001)

佐渡敬, 佐々木裕之
生殖遺伝学とインプリンティング
病理と臨床 18, 1223-1226 (2000)

著書 Books / 和文 Japanese
佐渡敬
第2部-1: X染色体不活性化
エピジェネティクスキーワード事典 (牛島俊和, 真貝洋一編), 100-108 羊土社 (2013)

佐渡敬
第IV-14章: 卵子とX染色体
卵子学 (森崇英総編集), 147-154, 京都大学学術出版会 (2011)

佐渡敬
性染色体の遺伝子量補償 (エピジェネティクス, 佐々木裕之編)
Springer Reviews シリーズ シュプリンガー・フェアラーク東京 117-127(2004)

佐渡敬, 佐々木裕之
性染色体の構造と機能
Springer Reviews シリーズ クロマチンと遺伝子機能制御 (堀越正美編), 15-24, シュプリンガー・フェアラーク東京 (2003)

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