原著論文(2004年までのImpact Factor はすべて2004年度版に準拠)

Tomino T, Tajiri H, Tatsuguchi T, Shirai T, Oisaki K, Matsunaga S, Sanematsu F, Sakata D, Yoshizumi T, Maehara Y, Kanai M, Cote JF, Fukui Y, Uruno T
DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation.
Biochem. Biophys. Res. Commun. 497:298-304, 2018 (IF=2.5)

Ushijima M, Uruno T, Nishikimi A, Sanematsu F, Kamikaseda K, Kunimura K, Sakata D, Okada T, Fukui Y
The rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production.
Front Immunol. 9:243, 2018 (IF=6.4)

Yamazaki S, Tanaka Y, Araki H, Kohda A, Sanematsu F, Arasaki T, Duan X, Miura F, Katagiri T, Shindo R, NakanoH, Ito T, Fukui Y, Endo S, Sumimoto H
The AP-1 transcription factor JunB is required for Th17 cell diferentiation.
Scientific Report 7:17402, 2017 (IF=4.3)

Okumura F, Joo-Okumura A, Obara K, Petersen A, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T
Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.
Mol. Biol. Cell. 28:3532-3541, 2017 (IF=3.7)

Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, Losic B, Shah H, Lee E, Wang M, Faith JJ, Kasarskis A, Brodmerkel C, Curran M, Das A, Friedman JR, Fukui Y, Humphrey MB, Iritani BM, Sibinga N, Tarrant TK, Argmann C, Hao K, Roussos P, Zhu J, Zhang B, Dobrin R, Mayer LF, Schadt EE
A functional genomics predictive network model identifies regulators of inflammatory bowel disease.
Nature Genetics 49:1437-1449, 2017 (IF=28.0)

Ackerknecht M, Gollmer K, Germann P, Ficht X, Abe J, Fukui Y, Swoger J, Ripoll J, Sharpe J, Sharpe J, Stein JV
Antigen availability and DOCK2-driven motility govern CD4+ T cell interactions with dendritic cells in vivo.
J. Immunol. 199:520-530, 2017(IF=4.9)

Yanagihara T, Tomino T, Uruno T, Fukui Y
Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.
Biochem. Biophys. Res. Commun. 491:1126, 2017(IF=2.5)

Tajiri H, Uruno T, Shirai T, Takaya D, Matsunaga S, Setoyama D, Watanabe M, Kukimoto-Niino M, Oisaki K, Ushijima M, Sanematsu F, Honma T, Terada T, Oki E, Shirasawa S, Maehara Y, Kang D, Cote JF, Yokoyama S, Kanai M, Fukui Y
Targeting Ras-Driven cancer cell survival and invasion through selective inhibition of DOCK1.
Cell Rep. 19:969-980, 2017(IF=8.3)

Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Nature Commun. 8:13946, 2017 (IF=11.3)

Shiraishi A, Uruno T, Sanematsu F, Ushijima M, Sakata D, Hara T, Fukui Y
DOCK8 regulates macrophage migration through Cdc42 activation and LRAP35a interaction.
J. Biol. Chem. 292:2191-2202, 2017 (IF=4.3)

Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T
ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.
J. Cell. Biol. 215:95-106, 2016 (IF=8.7)

Liu Z, Man SM, Zhu Q, Vogel P, Frase S, Fukui Y, Kanneganti TD
DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection.
Sci. Rep. 6:27814, 2016 (IF=5.2)

Okumura F, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin T, Fukui Y, Nakatsukasa K, Kamura T
Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α
Mol. Cell. Biol. 36:1803-1817, 2016 (IF=4.4)

Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Fukui Y
Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Nature Commun. 6:8820, 2015 (IF=11.5)

Guo X, Shi N, Cui X-B, Wang J-N, Fukui Y, Chen S-Y
Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling.
Cir. Res. 116:e71-80, 2015 (IF=11.8)

Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B, Stein JV
Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions.
J. Exp. Med. 211:2507-2517, 2014 (IF=13.2)

Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nacher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi M-D, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A
Neutrophils scan for activated platelets to initiate inflammation.
Science 346:1234-1238, 2014 (IF=31.5)

Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Cote JF, Sumimoto H, Fukui Y
DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.
J. Immunol. 193:5660-5667, 2014 (IF=5.3)

Abu-Thuraia A, Gauthier R, Chidiac R, Fukui Y, Screaton RA, Gratton JP, Cote JF
Axl phosphorylates Elmo scraffold proteins to promote Rac activation and cell invasion.
Mol. Cell. Biol. 35:76-87, 2015 (IF=5.0)

Wen Y, Elliott MJ, Huang Y, Miller TO, Corbin DR, Hussain L-R, Ratajczak MZ, Fukui Y, Ildstad ST
DOCK2 is critical for CD8TCR graft facilitating cells to enhance engraftment of hematopoietic stem and progenitor cells.
Stem Cells 32:2732-2743, 2014 (IF=7.1)

Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, Sanematsu F, Yamamura K, Terasawa M, Nishikimi A,
Cote JF, Fukui Y
DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.
J. Exp. Med. 211:1407-1419, 2014 (IF=13.2)

Damoulakis G, Gambardella L, Rossman K, Lawson C, Anderson K, Fukui Y, Welch H, Der CJ, Stephens L, Hawkins P
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signaling and actin polarity in neutrophils.
J. Cell Sci. 127:2589-2600, 2014 (IF=5.9)

Laurin M, Dumouchel A, Fukui Y, Cote JF
The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.
Small GTPases 4:4, 2013 (IF=xx)

Floc'h AL, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M
Annular PIP
3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse.

J. Exp. Med. 210:2721-2737, 2013

Kamakura S, Nomura M, hayase J, Iwakiri Y, Nishikimi A, Takayanagi R, Fukui Y, Sumimoto H
The cell polarity protein mlnsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway.
Dev. Cell. 26:292-302, 2013 (IF=12.9)

Sakai Y, Tanaka Y, Yanagihara T, Watanabe M, Duan X, Terasawa M, Nishikimi A, Sanematsu F, Fukui Y
The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation.
Blood 122:386-393, 2013 (IF=9.1)

Laurin M, Huber J, Pelletier A, Houalla T, Park M, Fukui Y, Haibe-Kains B, Muller WJ, Cote JF
Rac-specific guanine uncleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metasis.
Proc. Natl. Acad. Sci. USA 110:7434-7439, 2013 (IF=9.7)

Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Cote JF, Fukui Y
Phosphatidic acid-dependent recruitment and function of the Rat activator DOCK1 during dorsal ruffle formation.
J. Biol. Chem. 288:8092-8100, 2013 (IF=4.8)

Cimino PJ, Yang Y, Li X, Hemingway JF, Cherne MK, Khademi SB, Fukui Y
, Montine KS, Montine TJ, Keene CD
Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease.
Exp. Mol. Pathol. 94:366-371, 2013 (IF=2.4)

Unoki M, Masuda A, Dohmae N, Arita K, Yoshimatsu M, Iwai Y, Fukui Y, Ueda K, Hamamoto R, Shirakawa M, Sasaki H, Nakamura Y
Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6).
J. Biol. Chem. 288:6053-6062, 2013 (IF=4.8)

Fujimori S, Hirai N, Ohashi H, Masuoka K, Nishikimi A, Fukui Y, Washio T, Oshikubo T, Yamashita T, Miyamoto-Sato E
Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data.
Scientific Reports. 2:1-5, 2012 (IF=5.2)

Terasawa M, Uruno T, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y.
Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.
PLOS ONE 7(9):e46277, 2012 (IF=4.1)

Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
Blood 119:4451-4461, 2012 (IF=10.6)

Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sasaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y
Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
Chem. Biol. 19:488-497, 2012 (IF=5.8)

Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S
Structual basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Proc. Natl. Acad. Sci. USA 109:3305-3310, 2012 (IF=9.8)

Ippagunta SK, Subbarao Malireddi RK, Shaw PJ, Neale GA, Walle LV, Green DR, Fukui Y, Lamkanfi M, Kanneganti T-D
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.
Nature Immunol. 12:1010-1018, 2011 (IF=25.7)

Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Cote JF, Nagasawa T, Fukui Y
DOCK180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4.
Circ. Res. 107:1102-1105, 2010 (IF=9.2)

Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AC, Martin AM, Soriano SF, Natale D, Henrickson SE, Andrian UH,
Fukui Y, Mellado M, Deutsch U, Engelhardt B, Stein JV
Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and
non-redundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing..
Blood 116:915-925, 2010 (IF=10.6)

Kumar V, Scandella E, Danuser R, Onder L, Nitschke M, Fukui Y, Halin C, Ludewig B, Stein JV
Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway.
Blood 115:4725-4733, 2010 (IF=10.6)

Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Maeda N, Ishikawa T, Hoshino K, Uruno T, Cao Q,
Higashi S, Kawaguchi Y, Enjoji M, Takayanagi R, Kaisho T, Yoshikai Y, Fukui Y
Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid
dendritic cell activation.
J. Exp. Med. 207:721-730, 2010 (IF=15.5)

Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira A, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Enninger JM, Kunisawa J, Kiyono H
Id2-RORγt-, and LTβR-independent lymphoid organogenesis in ocular immunity.
J. Exp. Med. 206:2351-2364, 2009 (IF=15.5)

Lei Y, Liu C, Saito F, Fukui Y, Takahama Y
Role of DOCK2 and DOCK180 in fetal thymus colonization.
Eur. J. Immunol. 39:2695-2702, 2009 (IF=4.9)

Cimino PJ, Sokal I, Leverenz J, Fukui Y, Montine TJ
DOCK2 is microglial specific regulator of CNS innate immunity found in normal and Alzheimer's disease brain.
Am. J. Pathol. 175:1622-1630, 2009 (IF=5.7)

Gollmer K, Asperti-Boursin F, Tanaka Y, Okkenhaug K, Vanhaesebroeck B, Peterson JR, Fukui Y, Donnadieu E, Stein JV
CCL21 mediated CD4+ T cell costimulation via DOCK2/Rac-dependent pathway.
Blood 114:580-588, 2009 (IF=10.9)

Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.
Science 324:384-387, 2009

Nakasaki T, Tanaka T, Okudaira S, Hirosawa M, Umemoto E, Otani K, Jin S, Bai Z, Hayasaka H, Fukui Y, Aozasa K, Fujita N, Tsuruo T, Ozono K, Aoki J, Miyasaka M
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions.
Am. J. Pathol. 173:1566-1576, 2008 (IF=5.5)

Gotoh K, Tanaka Y, Nishikimi A, Inayoshi A, Enjoji M, Takayanagi R, Sasazuki T, Fukui Y
Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells.
Blood 111:2973-2976, 2008 (IF=10.4)

Kikuchi T, Kubonisni S, Shibakura M, Namba T, Fukui Y, Tanimoto M, Katayama Y
Dock2 participates in bone marrow lympho-hematopoiesis.
Biochem. Biophys. Res. Commun. 367:90-96, 2008 (IF=2.9)

Tanaka Y, Hamano S, Gotoh K, Murata Y, Kunisaki Y, Nishikimi A, Takii R, Kawaguchi M, Inayoshi A, Masuko S, Himeno K, Sasazuki T, Fukui Y
T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2.
Nature Immunol. 8:1067-1075, 2007 (IF=27.6)

Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martinez-A C, Fukui Y, von Andrian UH, Stein JV
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress.
J. Exp. Med. 204:497-510, 2007 (IF=14.0)

Handa Y, Suzuki M, Ohya K, Iwai H, Ishijima N, Koleske AJ, Fukui Y, Sasakawa C
Shignella IpgB1 promotes bacterial entry through the ELMO-Dock 180 machinery.
Nature Cell Biol. 9:121-128, 2007 (IF=19.7)

Higuchi N, Kato M, Kotoh K, Kohjima M, Aishima S, Nakamuta M, Fukui Y, Takayanagi R, Enjoji M
Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine.
Liver Int. 27:1342-1348, 2007 (IF=2.3)

Garcia-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C, Samaniego R, Fukui Y, Stein JV, Texidio J
DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin α4β1.
J. Immunol. 177:5215-5225, 2006 (IF=6.4)

Kunisaki Y, Nishikimi A, Tanaka Y, Takii R, Noda M, Inayoshi A, Watanabe K, Sanematsu F, Sasazuki T, Sasaki T, Fukui Y
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis.
J. Cell Biol. 174:647-652, 2006 (IF=11.0)

Shulman Z, Pasvolsky R, Woolf E, Grabovsky V, Feigelson SW, Erez N, Fukui Y, Alon R
DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration.
Blood 108:2150-2158, 2006 (IF=10.1)

Kunisaki Y, Tanaka Y, Sanui T, Inayoshi A, Noda M, Nakayama T, Harada M, Taniguchi M, Sasazuki T, Fukui Y
DOCK2 is required in T cell precursors for development of Vα14 NK T cells
J. Immunol.
176:4640-4645, 2006 (IF=6.4)

Jiang H,Pan F, Erickson LM, Jang M-S, Sanui T, Kunisaki Y, Sasazuki T, Kobayashi M, Fukui Y.
Deletion of Dock2,a regulator of the actin cytoskelton in lymphocytes,suppresses cardiac allograft rejection.
J. Exp. Med. 202:1121-1130, 2005 (IF=14.6)

Nombela-Arrieta C, Lacalle RA, Montoya MC, Kunisaki Y, Megias D Marques M, Carrera AC, Manes S, Fukui Y, Carlos Martinez-A, Stein, JV
Differential requirements for DOCK2 and phosphoinositide-3-Kinase γ during T and B lymphocyte homing
Immunity 21:429-441, 2004 (IF=15.4)

Kunisaki Y, Masuko S, Noda M, Inayoshi A, Sanui T, Harada M, Sasazuki T, Fukui Y
Defective fetal liver erythropoiesis and T-lymphopoiesis in mice lacking phosphatidylserine receptor.
Blood 103:3362-3364, 2004 (IF=9.8)

Sanui T, Inayoshi A, Noda M, Iwata E, Oike M, Sasazuki T, Fukui Y
DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-θ and LFA-1, in T cells.
Immunity 19:119-129, 2003 (IF=15.4)

Sanui T, Inayoshi A, Noda M, Iwta E, Stein JV, Sasazuki T, Fukui Y
DOCK2 regurates Rac activation and cytoskeltal reorganization through the interaction with ELMO1.
Blood 102:2948-2950, 2003 (IF=9.8)

Fukui Y, Hashimoto O, Sanui T, Koga H, Abe M,Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration.
Nature 412:826-831, 2001 (IF=32.2)

Oono T, Fukui Y, Masuko S, Hashimoto O, Sanui T, Inayoshi A, Noda M, Sata M, Sasazuki T
Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide.

J. Clin. Invest. 108: 1589-1596, 2001

Fukui Y, Oono T, Cabaniols JP, Nakao K, Hirokawa K, Inayoshi A, Sanui T, Kanellopoulos J, Iwata E, Noda M, Katsuki M, Kourilsky P, Sasazuki T
Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor-contact.
Proc. Natl. Acad. Sci. USA. 97:13760-13765, 2000 (IF=10.5)

Kawamura K, Yamamura T, Yokoyama K, Chui DH, Fukui Y, Sasazuki T, Inoko H, David CD, Tabira T
HLA-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice.
J. Clin. Invest. 105:977-984, 2000 (IF=14.2)

Sano T, Yamamoto K, Fukui Y, Sasazuki T
Spontaneous clustering of Thy-1 antigens on CD4+CD8+ thymocytes lacking TCR engagement by MHC/peptide complexes.
Eur. J. Immunol. 29:403-412, 1999 (IF=5.0)

Nishimura H, Washizu J, Naiki Y, Hara T, Fukui Y, Sasazuki T, Yoshikai Y
MHC class -dependent NK1.1+γδ T cells are induced in mice by Salmonella infection.
J. Immunol. 162:1573-1581, 1999 (IF=6.5)

Matsuki N, Ogasawara K, Takami K, Namba K, Takahashi A, Fukui Y, Sasazuki T, Iwabuchi K, Good RA, Onoe K
Prevention of Infection of influenza virus in DQ6 mice, a human model by a peptide vaccine prepared according to the cassette theory.
Vaccine 17:1161-1168, 1999 (IF=2.8)

Fukui Y, Hashimoto O, Inayoshi A, Gyotoku T, Sano T, Koga T, Gushima T, Sasazuki T
Highly restricted T cell repertore shaped by a single major histocompatibility complex-peptide ligand in the presense of a single rearranged T cell receptor β chain.
J. Exp. Med. 188:897-907, 1998 (IF=14.6)

Gapin L, Fukui Y, Kanellopoulos J, Sano T, Casrouge A, Mailer V, Beaudoing E, GautheretD, Claverie JM, Sasazuki T, Kourilsky P
Quantiative analysis of the T-cell repertoire by a single peptide/MHC complex..
J. Exp. Med. 187:1871-1883, 1998 (IF=14.6)

Gyotoku T, Fukui Y, Sasazuki T
An endogenously processed self peptide and the corresponding exogenous peptide bound to the same MHC class II molecule could be distinct ligands for TCR with different kinetic stability.
Eur. J. Immunol. 28:4050-4061, 1998 (IF=5.0)

Takahashi A, Ogasawara K, Matsuki N, Fujinaga K, Nakaya T, Ikuta K, Auwanit W, Honda M, Fukui Y, Sasazuki T, Iwabuchi K, Onoe K.
Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ mice.
Vaccine 16:1537-1543, 1998 (IF=2.8)

Fukui Y, Ishimoto T, Utsuyama M, Gyotoku T, Koga T, Nakao K, Hirokawa K, Katsuki M, Sasazuki T
Positive and negative CD4+ thymocyte selection by a single MHC classII/peptide ligand affected by its expression level in the thymus.
Immunity 6:401-410, 1997 (IF=15.4)

Fukui Y, Yamamoto K, Koga T, Yamane K, Sasazuki T
Differential requirement of MHC class I molecules expressed on haematopoietic cells for positive selection of CD4+ thymocytes in TCRαβ and TCRβ transgenic mice.
Int. Immunol. 9:1385-1391,1997 (IF=3.5)

Ishimoto T, Yamamoto K, Fukui Y, Fukuda Y, Dohi K, Sasazuki T
In vitro and in vivo evidence for high frequency of I-Ab-reactive CD4+ T cells in HLA-DQ or HLA-DRA transgenic mice lacking MHC class I and/or class II expression
J. Immunol. 159:3717-3722, 1997 (IF=6.5)

Takeshita T, Fukui Y, Yamamoto K, Yamane K, Inamitsu T, Kamikawaji N, Sasazuki T
Identification of HLA-DQ-derived peptide recognized by mouse MHC class I H-2Db-restricted CD8+ T cells in HLA-DQ6 transgenic mice.
J. Human Genet. 42:225-232, 1997 (IF=2.3)

Yamamoto K, Fukui Y, Esaki Y, Inamitsu T, Sudo T, Yamane K, Kamikawaji N, Kimura A, Sasazuki T
Functional interaction between human histocompatibility leukocyte antigen (HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DO transgenic mice.
J. Exp. Med. 180:165-171, 1994 (IF=14.6)

Esaki Y, Fukui Y, Sudo T, Yamamoto K, Inamitsu T, Nishimura Y, Hirokawa K, Kimura A, Sasazuki T
Role of human major histocompatibility complex DQ molecules in superantigenicity of of Streptococcus-derived protein.
Infect. Immun. 62:1228-1235, 1994 (IF=4.0)

Fukui Y, Yamamoto K, Yokoyama N, Iwanaga T, Kurashima C, Esaki Y, Kimura A, Akashi T, Hirokawa K, Sasazuki T
Restricted expression of transgenic HLA-DRA gene in thymic epithelial cells and its role in acquisition of T cell tolerance to self-superantigens and processed DR-derived peptide.
Eur. J. Immunol. 23:1678-1686, 1993 (IF=5.0)

Fukui Y, Ezaki Y, Kimura A, Hirokawa K, Nishimura Y, Sasazuki T
T cell repertoire in a strain of transgenic C57BL/6 mice with HLA-DRA gene on the X chromosome.
Immunogenetics 37:204-211, 1993 (IF=2.9)

Esaki I, Kaneda H, Sakai K, Fukui Y, Singu M, Nobunaga M, Watanabe T
Restricted diversity of the variable region nucleotide sequences of the heavy and light chains of a human rheumatoid factor.
Arthritis and Rheumatism 34:343-350, 1991 (IF=7.4)

Todd JA, Fukui Y, Kitagawa T, Sasazuki T
The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.
Proc. Natl. Acad. Sci., USA 87:1094-1098, 1990 (IF=10.5)

Fukui Y, Nishimura Y, Iwanaga T, Kimura A, Inamitsu T, Hanaoka Y, Kitagawa T, Sasazuki T
Glycosuria and insulitis in NOD mice expressing the HLA-DQw6 molecule.
J. Immunogenet. 16:445-453, 1989


Furue M, Yamamura K, Kido-Nakahara M, Nakahara T, Fukui Y
Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis.
Allergy 2017, in press (IF=7.4)



Nishikimi A, Kukimoto-Niino M, Yokoyama S, Fukui Y
Immune regulatory functions of DOCK family proteins in health and disease.
Exp. Cell. Res., 319:2343-2349, 2013






医学のあゆみ、11: 2915-2920、2005

ゲノム医学、4: 331-336、2004

細胞工学、22: 1204-1207、2003


Molecular Medicine 増刊「免疫2003」39:22-30、2002

蛋白質核酸酵素増刊「免疫研究の最前線:高次複雑免疫システムの包括的理解をめざして」47: 2194-2199、2002

Medical Science Digest 28:550-551、2002

医学のあゆみ増刊「免疫疾患?state of arts」342-346、2002



血液・免疫・腫瘍 BIC Forum別冊、14:41-48、1999


Molecular Medicine 増刊「免疫1998-99」、35:56-64、1998


MHC class I
Molecular Medicine 増刊号ノックアウトマウス・データブック、34:324-325、1997


Medical Immunology 21:687-698、1991

Diabetes Frontier、35-41、1991




「免疫学イラストレイテッド」高津聖志・清野宏・三宅健介 監訳、105-124, 2009

「戸田新細菌学」吉田眞一・柳 雄介・吉開泰信編、南山堂、390-399, 2007

「エッセンシャル免疫学」笹月健彦 監訳、67-96, 2007

Sakaguchi S, Hori S, Fukui Y, Sasazuki T, Sakaguchi N, Takahashi T
Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological serf-tolerance.
Novartis Found Symp., 252:6-16, 2003

Sasazuki T, Fukui Y
Contribution of MHC and non-MHC loci to the susceptibility to the organ-specific autoimmune disease.
Allergy & Clinical Immunology Supplement (Hogrefe & Huber Publishers). 2000
Sasazuki T, Fukui Y
Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand invivo.
HLA 1996 (Oxford University Press). 1997


Fukui Y, Esaki Y, Yasunami M, Kimura A, Hirokawa K, Nishimura Y, Sasazuki T
T cell repertoire and self-tolerance in the transgenic mice with HLA-DRAon X chromosome.
HLA 1991 vol.II(Tsuji K, Aizawa M, Sasazuki T. eds.) pp648-650, Oxford University Press, Oxford, 1992

Esaki Y, Fukui Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T
Functional expression of HLA-DQ4 genes in a line of transgenic C57BL/6 mouse.
HLA 1991 vol.II(Tsuji K, Aizawa M, Sasazuki T. eds.) pp651-653, Oxford University Press, Oxford, 1992